Predicting chiral separations is challenging. Using standard capillary columns, general predictions about separations can be made based on the solubility of compounds in different phases; however, chiral predictions are far more complicated.
To make this decision somewhat easier, we compiled resolution values for the enantiomers of 21 chiral compounds with different functional groups, such as terpenes, alcohols or lactones.
| Column Resolution Factors | ||||||||
| Compounds | Rt-βDEX sm | Rt-βDEX se | Rt-βDEX sp | Rt-βDEX sa | Rt-βDEX cst | Rt-βDEX m | ||
| Terpenes | 1 | α-pinene | 3.14 | 0.82 | ns | ns | 0.82 | 3.19 |
| 2 | limonene | 5.60 | 8.05 | 1.22 | ns | 2.04 | 1.41 | |
| Alcohols | 3 | 1-octen-3-ol | 1.08 | ns | ns | 2.00 | ns | ns |
| 4 | linalool | 3.10 | 5.96 | 1.79 | 1.60 | 2.25 | 1.01 | |
| 5 | α-terpineol | 4.72 | 5.20 | 1.29 | 2.82 | 2.69 | 1.54 | |
| 6 | terpinen-4-ol | 1.90 | 1.92 | ns | 2.47 | ns | 1.41 | |
| 7 | isoborneol | 3.76 | 3.35 | ns | 0.79 | 1.87t | 2.15 | |
| 8 | β-citronellol | 0.80 | 0.89 | ns | 0.98 | ns | ns | |
| 9 | menthol | 1.24 | 1.24 | 1.07 | 0.93 | 0.89 | 1.58 | |
| 10 | 2,3-butanediol | 6.44 | 7.10 | 1.46 | 2.61 | 1.27 | 2.43 | |
| 11 | 1-phenylethanol | 7.52 | 6.52 | ns | 6.43 | 4.87 | 5.88 | |
| Ketones | 12 | camphor | 1.70 | 2.13 | 0.50 | 4.20 | 2.22t | ns |
| 13 | α-ionone | 5.67 | 3.31 | 0.80 | 4.69 | 1.37 | 2.81 | |
| 14 | menthone | 0.59 | 5.76 | ns | 1.16 | 2.60 | 4.11 | |
| Lactones | 15 | γ-nonalactone | 4.19 | 5.07 | 2.11 | 4.00 | 3.82 | 1.03 |
| 16 | γ-undecalactone | 2.39 | 3.24 | 1.20 | 3.65 | 3.18 | ns | |
| 17 | δ-dodecalactone | 0.80 | ns | ns | 1.91 | 1.69 | ns | |
| 18 | ethyl-2-methylbutyrate | 3.94 | 4.66 | ns | ns | ns | 0.92 | |
| Esters | 19 | linalyl acetate | ns | 2.36 | ns | ns | ns | ns |
| 20 | styrene oxide | 4.53 | 10.77 | 2.86 | 2.26 | 1.16t | 3.03 | |
| Epoxides | 21 | trans-linalool oxide | 9.71 | 2.96 | ns | 1.20 | 3.02t | 7.44 |
| 21 | cis-linalool oxide | 6.06 | 4.28 | ns | 0.91 | 2.19t | 4.38 | |
