{"id":43521,"date":"2020-10-20T00:00:00","date_gmt":"2020-10-20T00:00:00","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/lc-ms-ms-analyse-von-paraquat-und-diquat-ohne-ionenpaarreagenzien\/"},"modified":"2026-02-18T18:23:57","modified_gmt":"2026-02-18T18:23:57","slug":"lc-ms-ms-analyse-von-paraquat-und-diquat-ohne-ionenpaarreagenzien","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/de\/artikel\/evss2791-de\/lc-ms-ms-analyse-von-paraquat-und-diquat-ohne-ionenpaarreagenzien","title":{"rendered":"LC-MS\/MS-Analyse von Paraquat und Diquat ohne Ionenpaarreagenzien"},"content":{"rendered":"\n<ul class=\"wp-block-list\">\n<li>Gute Retention und Peakform ohne Kontamination des Systems durch Ionenpaarreagenzien.<\/li>\n\n\n\n<li>Konstante Aufl\u00f6sung und Response mit MS-kompatiblen mobilen Phasen..<\/li>\n\n\n\n<li>Schnelle Gradientenmethode (7 Minuten) f\u00fcr hohen Probendurchsatz.<\/li>\n<\/ul>\n\n\n\n<p>Paraquat ist ein relativ kosteng\u00fcnstiges, schnell wirkendes, nichtselektives Kontaktherbizid. Aufgrund dieser Eigenschaften wird es in vielen Entwicklungsl\u00e4ndern in gro\u00dfem Stil zur Unkrautbek\u00e4mpfung bei landwirtschaftlichen Kulturpflanzen eingesetzt. Bei Beachtung der notwendigen Vorsichtsma\u00dfnahmen ist die Anwendung von Paraquat zwar relativ sicher, versehentliche oder vors\u00e4tzliche Einnahme hat jedoch eine \u00e4u\u00dferst hohe Sterblichkeitsrate zur Folge. Deshalb ist die Verwendung von Paraquat in vielen L\u00e4nder eingeschr\u00e4nkt. Diquat ist ein verwandtes Herbizid, das h\u00e4ufig in Verbindung mit Paraquat eingesetzt und wegen seiner potenziellen toxischen Wirkungen auf das zentrale Nervensystem \u00fcberwacht wird. Die LC-MS\/MS-Analyse von Paraquat und Diquat in Nutzpflanzen mit niedrigem Feuchtegehalt, in Trinkwasser und in Oberfl\u00e4chenwasser ist ein wichtiges Tool zur Vermeidung oder Begrenzung der Exposition von Mensch und Umwelt.<\/p>\n\n\n\n<p>Normalerweise wird die LC-MS\/MS-Analyse von Paraquat und Diquat mithilfe von Ionenpaarreagenzien durchgef\u00fchrt, um ausreichende Retention, gute Aufl\u00f6sung und eine schmale, symmetrische Peakform zu erreichen. Ionenpaarreagenzien konkurrieren jedoch bei der Ionisierung mit den Zielanalyten und f\u00fchren oft zu verringerter Empfindlichkeit. Au\u00dferdem k\u00f6nnen diese Reagenzien das LC-MS\/MS-System kontaminieren, was h\u00e4ufiges Abschalten zur gr\u00fcndlichen Reinigung erfordert.<\/p>\n\n\n\n<p>Jetzt haben wir eine Methode zur LC-MS\/MS-Analyse von Paraquat und Diquat ohne Verwendung von Ionenpaarreagenzien entwickelt, die dennoch gute Retention und Peakformen ergibt. Beide Zielanalyten wurden vollst\u00e4ndig getrennt und zeigten eine deutlich h\u00f6here Empfindlichkeit bei 50 ng\/mL (50 ppb) im Vergleich zu Ionenpaarmethoden. Diese schnelle, nur 7 Minuten dauernde Analyse lieferte konstante MS-Ergebnisse bei einer mobilen Phase mit 50 mM Puffer. Diese Pufferkonzentration liegt innerhalb des normalerweise empfohlenen Bereiches zur Minimierung der Kontamination und Wartung von LC-MS\/MS-Systemen.<\/p>\n\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\"><\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<div class=\"wp-block-custom-chromatogram-article\"><div class=\"wp-block-custom-chromatogram-article\"><div class=\"chromatogram-image regular-image\"><img decoding=\"async\" src=\"https:\/\/ez.restek.com\/images\/cgram\/lc_fs0512.png\" alt=\"Paraquat and Diquat on Raptor HILIC-Si\" title=\"-\"><\/div><p class=\"article-id\" style=\"text-align:center\"> lc_fs0512<\/p><div class=\"chromatogram-peaks\"><h4>Peaks<\/h4><table class=\"peaks col-12\">\n<thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> (min)<\/th><th style=\"text-align: center;width: 75px\">Precursor Ion 1<\/th><th style=\"text-align: center;width: 75px\">Product Ion 1<\/th><th style=\"text-align: center;width: 75px\">Precursor Ion 2<\/th><th style=\"text-align: center;width: 75px\">Product Ion 2<\/th><\/tr><\/thead>\n<tbody><tr><td class=\"num\">1.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for Diquat\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/6385-62-2\/Diquat\" target=\"_blank\" rel=\"noopener\">Diquat<\/a><\/td><td class=\"oth\">3.25<\/td><td class=\"oth\">183.3<\/td><td class=\"oth\">157.2<\/td><td class=\"oth\">183.3<\/td><td class=\"oth\">130.1<\/td><\/tr>\n<tr><td class=\"num\">2.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for Paraquat\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/1910-42-5\/Paraquat\" target=\"_blank\" rel=\"noopener\">Paraquat<\/a><\/td><td class=\"oth\">3.46<\/td><td class=\"oth\">185.3<\/td><td class=\"oth\">170.3<\/td><td class=\"oth\">171.3<\/td><td class=\"oth\">77.2<\/td><\/tr>\n<\/tbody><\/table><\/div><div class=\"chromatogram-conditions\"><h4>Conditions<\/h4><div class=\"conditions-container container-fluid\"><div class=\"row\"><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Column<\/th><td>Raptor HILIC-Si  (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/9310A52?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=LC_FS0512\" rel=\"noopener\">cat.# 9310A52<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Dimensions:<\/th><td>50 mm x 2.1 mm ID<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Particle Size:<\/th><td>2.7 \u00b5m<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Pore Size:<\/th><td>90 \u00c5<\/td><\/tr><tr><td><\/td><tr><th class=\"sub conditions_header\" scope=\"row\">Temp.:<\/th><td>45 \u00b0C<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Standard\/Sample<\/th><td>Paraquat &amp; diquat calibration mix (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/32437?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=LC_FS0512\" rel=\"noopener\">cat.# 32437<\/a>)<\/td><\/tr>\n<tr><th class=\"sub conditions_header\" scope=\"row\">Diluent:<\/th><td>Mobile phase B<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Conc.:<\/th><td>50 ng\/mL<\/td><\/tr><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Vol.:<\/th><td>5 \u00b5L <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Mobile Phase<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">A:<\/th><td>Water, 50 mM ammonium formate, 0.5% formic acid <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">B:<\/th><td>25:75 Water:acetonitrile, 50 mM ammonium formate, 0.5% formic acid <\/td><\/tr><tr><td><\/td><td><table class=\"cgram_ramp\"><thead><tr><th>Time (min)<\/th><th>Flow (mL\/min)<\/th><th>%A<\/th><th>%B<\/th><\/tr><\/thead><tbody><tr><td>0.00<\/td><td>0.6<\/td><td>0<\/td><td>100<\/td><\/tr><tr><td>4.00<\/td><td>0.6<\/td><td>35<\/td><td>65<\/td><\/tr><tr><td>4.01<\/td><td>0.6<\/td><td>0<\/td><td>100<\/td><\/tr><tr><td>7.00<\/td><td>0.6<\/td><td>0<\/td><td>100<\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/table><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Detector<\/th><td>MS\/MS<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ion Mode:<\/th><td>ESI+ <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Mode:<\/th><td>MRM <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Instrument<\/th><td>HPLC<\/td><\/tr><\/table><\/div><\/div><\/div><div class=\"chromatogram-pdf-link\"><a href=\"https:\/\/ez.restek.com\/images\/cgram\/lc_fs0512.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"18\" height=\"18\" viewBox=\"0 0 18 18\"><g data-name=\"Group 2996\"><path data-name=\"Rectangle 1246\" d=\"M0 0h18v18H0z\" style=\"fill: none;\"><\/path><\/g><g data-name=\"Group 2997\"><path data-name=\"Path 729\" d=\"M13.412 11.4v2.017H5.345V11.4H4v2.017a1.349 1.349 0 0 0 1.345 1.345h8.068a1.349 1.349 0 0 0 1.345-1.345V11.4zm-.672-2.694-.948-.948-1.741 1.735V4H8.706v5.493L6.965 7.758l-.948.948 3.361 3.361z\" transform=\"translate(-.437 -.414)\" style=\"fill: rgb(13, 123, 196);\"><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Die LC-MS\/MS-Analyse von Paraquat- und Diquat-Herbiziden ist ein wichtiges Instrument zum Schutz der Gesundheit von Mensch und Umwelt. Die Ionenpaarungsreagenzien, die \u00fcblicherweise zur Verbesserung von Retention, Aufl\u00f6sung und Peakform verwendet werden, wirken sich jedoch negativ auf die Empfindlichkeit aus und k\u00f6nnen das System verunreinigen, was eine h\u00e4ufige Reinigung erforderlich macht. Die hier vorgestellte LC-MS\/MS-Analyse von Paraquat und Diquat bietet eine vollst\u00e4ndige Trennung und eine gute Peak-Antwort f\u00fcr beide Zielanalyten in einem schnellen, 7-min\u00fctigen Gradientenlauf ohne die Verwendung von st\u00f6renden Ionenpaarungsreagenzien.<\/p>\n","protected":false},"author":11,"featured_media":6784,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[787],"tags":[],"industries-application":[2232,2230],"post-badge":[],"resource-type":[],"product-library":[2481,2507,2499,2482],"resource-technique":[2326,2328,2363],"ppma_author":[414],"class_list":["post-43521","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-artikel","industries-application-trinkwasser-abwasseruntersuchungen","industries-application-umweltbereich","product-library-flussigchromatographie-produkte","product-library-flussige-referenzstandards","product-library-lc-saulen","product-library-referenzstandards","resource-technique-flussigchromatografie","resource-technique-massenspektrometrie-ms","resource-technique-ms-ms-de"],"acf":[],"taxonomy_info":{"category":[{"value":787,"label":"Artikel"}],"industries-application":[{"value":2232,"label":"Trinkwasser- 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