{"id":43725,"date":"2025-10-03T21:35:40","date_gmt":"2025-10-03T21:35:40","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/rapid-lpgc-ms-analysis-of-arylamines-increases-throughput-and-reduces-helium-use\/"},"modified":"2026-01-03T17:35:02","modified_gmt":"2026-01-03T17:35:02","slug":"rapid-lpgc-ms-analysis-of-arylamines-increases-throughput-and-reduces-helium-use","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/de\/articles-fr\/gnfa4235\/rapid-lpgc-ms-analysis-of-arylamines-increases-throughput-and-reduces-helium-use","title":{"rendered":"Rapid LPGC-MS Analysis of Arylamines Increases Throughput and Reduces Helium Use"},"content":{"rendered":"\n<ul class=\"wp-block-list\">\n<li>Analyze arylamines 3.3x faster than conventional GC-MS.<\/li>\n\n\n\n<li>Cut costs by reducing helium consumption 81%.<\/li>\n\n\n\n<li>Pre-connected LPGC column kit prevents leaks, simplifies installation, and allows large-volume injection.<\/li>\n<\/ul>\n\n\n\n<p>Azo dyes are synthetically produced colorants that are commonly used in the food, cosmetic, pharmaceutical, and textile industries. They are present in a wide variety of consumer products, and some can produce carcinogenic or mutagenic arylamines as breakdown products. Due to concerns about human health and exposure, effective methods are needed for the analysis of arylamines. Testing is usually performed by conventional GC-MS or LC-MS, but long analysis times limit sample throughput.&nbsp;<\/p>\n\n\n\n<p>A much faster alternative, low-pressure GC-MS (LPGC-MS) is a paired-column technique that can bring significant speed gains to labs analyzing arylamines. This approach uses the MS vacuum to lower pressure within the analytical column, thus increasing speed. For example, in the analysis of arylamines (22 of which are regulated by EU REACH legislation [1]) shown in Figure 1, the run time was 3.3x faster than the conventional method, and it also used 81% less helium, which provides a substantial cost savings.&nbsp;<\/p>\n\n\n\n<p>LPGC-MS only works because the inlet pressure is maintained by pairing the analytical column to a narrow restrictor column. However, due to the difference in tubing diameters, it can be difficult to make a robust connection manually, which has limited adoption of the technique. LPGC column kits from Restek solve this problem because they are factory connected and individually leak checked, which ensures a leak-free connection and simplifies setup. Visit <a href=\"https:\/\/www.restek.com\/articles\/an-introduction-to-low-pressure-GC-MS-LPGC-MS\" target=\"_blank\" rel=\"noopener\">www.restek.com\/lpgc<\/a> to learn more about this powerful technique.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">References<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Regulation (EC) No. 1907\/2006 of the European Parliament and of the Council of 18 December 2006 Concerning the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH). <a href=\"https:\/\/osha.europa.eu\/en\/legislation\/directives\/regulation-ec-no-1907-2006-of-the-european-parliament-and-of-the-council\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/osha.europa.eu\/en\/legislation\/directives\/regulation-ec-no-1907-2006-of-the-european-parliament-and-of-the-council<\/a>.<\/li>\n<\/ol>\n\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\"><strong>Figure 1:\u00a0<\/strong>Arylamines on LPGC Rxi-35Sil MS Compared to Conventional GC-MS Analysis<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<div class=\"wp-block-custom-chromatogram-article\"><div class=\"wp-block-custom-chromatogram-article\"><div class=\"chromatogram-image wide-image\"><img decoding=\"async\" src=\"https:\/\/ez.restek.com\/images\/cgram\/gc_gn1244.png\" alt=\"Comparison of Conventional and LPGC-MS Analysis of REACH Carcinogenic Arylamines\" title=\"-\"><\/div><p class=\"article-id\" style=\"text-align:center\"> GC_GN1244<\/p><div class=\"chromatogram-peaks\"><h4>Peaks<\/h4><table class=\"peaks col-lg-6 col-12 peak-50\">\n<thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub>  (30 m)<\/th><th style=\"text-align: center;width: 75px\">tR (LPGC)<\/th><th style=\"text-align: center;width: 75px\">Conc. (ppm)<\/th><th style=\"text-align: center;width: 75px\">Quant Ion<\/th><\/tr><\/thead>\n<tbody><tr><td class=\"num\">1.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for o-Toluidine\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/95-53-4\/o-Toluidine\" target=\"_blank\" rel=\"noopener\">o-Toluidine<\/a><\/td><td class=\"oth\">3.217<\/td><td class=\"oth\">1.207<\/td><td class=\"oth\">2<\/td><td class=\"oth\">107<\/td><\/tr>\n<tr><td class=\"num\">2.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for o-Anisidine\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/90-04-0\/o-Anisidine\" target=\"_blank\" rel=\"noopener\">o-Anisidine<\/a><\/td><td class=\"oth\">4.42<\/td><td class=\"oth\">1.589<\/td><td class=\"oth\">2<\/td><td class=\"oth\">123<\/td><\/tr>\n<tr><td class=\"num\">3.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 4-Chloroaniline\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/106-47-8\/4-Chloroaniline\" target=\"_blank\" rel=\"noopener\">4-Chloroaniline<\/a><\/td><td class=\"oth\">4.832<\/td><td class=\"oth\">1.71<\/td><td class=\"oth\">2<\/td><td class=\"oth\">127<\/td><\/tr>\n<tr><td class=\"num\">4.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for p-Cresidine\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/120-71-8\/p-Cresidine\" target=\"_blank\" rel=\"noopener\">p-Cresidine<\/a><\/td><td class=\"oth\">5.519<\/td><td class=\"oth\">1.92<\/td><td class=\"oth\">2<\/td><td class=\"oth\">137<\/td><\/tr>\n<tr><td class=\"num\">5.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 2,4,5-Trimethylaniline\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/137-17-7\/2,4,5-Trimethylaniline\" target=\"_blank\" rel=\"noopener\">2,4,5-Trimethylaniline<\/a><\/td><td class=\"oth\">5.582<\/td><td class=\"oth\">1.935<\/td><td class=\"oth\">2<\/td><td class=\"oth\">135<\/td><\/tr>\n<tr><td class=\"num\">6.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 3-Chloro-o-toluidine\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/87-60-5\/3-Chloro-o-toluidine\" target=\"_blank\" rel=\"noopener\">3-Chloro-o-toluidine<\/a><\/td><td class=\"oth\">5.902<\/td><td class=\"oth\">2.026<\/td><td class=\"oth\">2<\/td><td class=\"oth\">141<\/td><\/tr>\n<tr><td class=\"num\">7.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 4-Chloro-o-toluidine\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/95-69-2\/4-Chloro-o-toluidine\" target=\"_blank\" rel=\"noopener\">4-Chloro-o-toluidine<\/a><\/td><td class=\"oth\">6.025<\/td><td class=\"oth\">2.061<\/td><td class=\"oth\">2<\/td><td class=\"oth\">141<\/td><\/tr>\n<tr><td class=\"num\">8.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 2,4-Diaminotoluene\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/95-80-7\/2,4-Diaminotoluene\" target=\"_blank\" rel=\"noopener\">2,4-Diaminotoluene<\/a><\/td><td class=\"oth\">7.637<\/td><td class=\"oth\">2.523<\/td><td class=\"oth\">2<\/td><td class=\"oth\">122<\/td><\/tr>\n<tr><td class=\"num\">9.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 2,4-Diaminoanisole\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/615-05-4\/2,4-Diaminoanisole\" target=\"_blank\" rel=\"noopener\">2,4-Diaminoanisole<\/a><\/td><td class=\"oth\">8.89<\/td><td class=\"oth\">2.872<\/td><td class=\"oth\">2<\/td><td class=\"oth\">138<\/td><\/tr>\n<tr><td class=\"num\">10.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 2-Naphthylamine\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/91-59-8\/2-Naphthylamine\" target=\"_blank\" rel=\"noopener\">2-Naphthylamine<\/a><\/td><td class=\"oth\">9.773<\/td><td class=\"oth\">3.112<\/td><td class=\"oth\">2<\/td><td class=\"oth\">143<\/td><\/tr>\n<tr><td class=\"num\">11.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 2-Aminobiphenyl\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/90-41-5\/2-Aminobiphenyl\" target=\"_blank\" rel=\"noopener\">2-Aminobiphenyl<\/a><\/td><td class=\"oth\">9.892<\/td><td class=\"oth\">3.148<\/td><td class=\"oth\">2<\/td><td class=\"oth\">169<\/td><\/tr>\n<tr><td class=\"num\">12.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 2-Amino-4-nitrotoluene\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/99-55-8\/2-Amino-4-nitrotoluene\" target=\"_blank\" rel=\"noopener\">2-Amino-4-nitrotoluene<\/a><\/td><td class=\"oth\">10.537<\/td><td class=\"oth\">3.325<\/td><td class=\"oth\">2<\/td><td class=\"oth\">152<\/td><\/tr>\n<\/tbody><\/table>\n<table class=\"peaks col-lg-6 col-12 peak-50\"><thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub>  (30 m)<\/th><th style=\"text-align: center;width: 75px\">tR (LPGC)<\/th><th style=\"text-align: center;width: 75px\">Conc. (ppm)<\/th><th style=\"text-align: center;width: 75px\">Quant Ion<\/th><\/tr><\/thead><tbody>\n<tr><td class=\"num\">13.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 4-Aminobiphenyl\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/92-67-1\/4-Aminobiphenyl\" target=\"_blank\" rel=\"noopener\">4-Aminobiphenyl<\/a><\/td><td class=\"oth\">12.154<\/td><td class=\"oth\">3.767<\/td><td class=\"oth\">2<\/td><td class=\"oth\">169<\/td><\/tr>\n<tr><td class=\"num\">14.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for p-Aminoazobenzene\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/60-09-3\/p-Aminoazobenzene\" target=\"_blank\" rel=\"noopener\">p-Aminoazobenzene<\/a><\/td><td class=\"oth\">15.95<\/td><td class=\"oth\">4.805<\/td><td class=\"oth\">2<\/td><td class=\"oth\">197<\/td><\/tr>\n<tr><td class=\"num\">15.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 4,4&#039;-Oxydianiline\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/101-80-4\/4,4&#039;-Oxydianiline\" target=\"_blank\" rel=\"noopener\">4,4&#8242;-Oxydianiline<\/a><\/td><td class=\"oth\">16.613<\/td><td class=\"oth\">4.99<\/td><td class=\"oth\">2<\/td><td class=\"oth\">200<\/td><\/tr>\n<tr><td class=\"num\">16.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 4,4&#039;-Diaminodiphenylmethane\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/101-77-9\/4,4&#039;-Diaminodiphenylmethane\" target=\"_blank\" rel=\"noopener\">4,4&#8242;-Diaminodiphenylmethane<\/a><\/td><td class=\"oth\">16.714<\/td><td class=\"oth\">5.016<\/td><td class=\"oth\">2<\/td><td class=\"oth\">198<\/td><\/tr>\n<tr><td class=\"num\">17.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for Benzidine\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/92-87-5\/Benzidine\" target=\"_blank\" rel=\"noopener\">Benzidine<\/a><\/td><td class=\"oth\">16.787<\/td><td class=\"oth\">5.034<\/td><td class=\"oth\">2<\/td><td class=\"oth\">184<\/td><\/tr>\n<tr><td class=\"num\">18.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for o-Aminoazotoluene\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/97-56-3\/o-Aminoazotoluene\" target=\"_blank\" rel=\"noopener\">o-Aminoazotoluene<\/a><\/td><td class=\"oth\">17.53<\/td><td class=\"oth\">5.24<\/td><td class=\"oth\">2<\/td><td class=\"oth\">225<\/td><\/tr>\n<tr><td class=\"num\">19.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 3,3&#039;-Dimethyl-4,4&#039;-diaminodiphenylmethane\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/838-88-0\/3,3&#039;-Dimethyl-4,4&#039;-diaminodiphenylmethane\" target=\"_blank\" rel=\"noopener\">3,3&#8242;-Dimethyl-4,4&#8242;-diaminodiphenylmethane<\/a><\/td><td class=\"oth\">18.23<\/td><td class=\"oth\">5.436<\/td><td class=\"oth\">2<\/td><td class=\"oth\">226<\/td><\/tr>\n<tr><td class=\"num\">20.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 3,3&#039;-Dimethylbenzidine\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/119-93-7\/3,3&#039;-Dimethylbenzidine\" target=\"_blank\" rel=\"noopener\">3,3&#8242;-Dimethylbenzidine<\/a><\/td><td class=\"oth\">18.483<\/td><td class=\"oth\">5.504<\/td><td class=\"oth\">2<\/td><td class=\"oth\">212<\/td><\/tr>\n<tr><td class=\"num\">21.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 4,4\u2019-Thiodianiline\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/139-65-1\/4,4\u2019-Thiodianiline\" target=\"_blank\" rel=\"noopener\">4,4\u2019-Thiodianiline<\/a><\/td><td class=\"oth\">19.439<\/td><td class=\"oth\">5.765<\/td><td class=\"oth\">2<\/td><td class=\"oth\">216<\/td><\/tr>\n<tr><td class=\"num\">22.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 3,3&#039;-Dichlorobenzidine\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/91-94-1\/3,3&#039;-Dichlorobenzidine\" target=\"_blank\" rel=\"noopener\">3,3&#8242;-Dichlorobenzidine<\/a><\/td><td class=\"oth\">19.795<\/td><td class=\"oth\">5.864<\/td><td class=\"oth\">2<\/td><td class=\"oth\">252<\/td><\/tr>\n<tr><td class=\"num\">23.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 4,4&#039;-Methylenebis(2-chloroaniline)\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/101-14-4\/4,4&#039;-Methylenebis(2-chloroaniline)\" target=\"_blank\" rel=\"noopener\">4,4&#8242;-Methylenebis(2-chloroaniline)<\/a><\/td><td class=\"oth\">19.795<\/td><td class=\"oth\">5.864<\/td><td class=\"oth\">2<\/td><td class=\"oth\">266<\/td><\/tr>\n<tr><td class=\"num\">24.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 3,3&#039;-Dimethoxybenzidine\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/119-90-4\/3,3&#039;-Dimethoxybenzidine\" target=\"_blank\" rel=\"noopener\">3,3&#8242;-Dimethoxybenzidine<\/a><\/td><td class=\"oth\">19.905<\/td><td class=\"oth\">5.898<\/td><td class=\"oth\">2<\/td><td class=\"oth\">244<\/td><\/tr>\n<\/tbody><\/table><\/div><div class=\"chromatogram-conditions\"><h4>Conditions<\/h4><div class=\"conditions-container container-fluid\"><div class=\"row\"><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Column<\/th><td>See notes<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Standard\/Sample<\/th><td><\/td><\/tr><tr><td><\/td><td>AccuStandard carcinogenic aryl amine mix (AE-00049-R1-10X)<\/td><\/tr><tr><td><\/td><td>AccuStandard 2,4-diaminoanisole (ALR-070S-R2)<\/td><\/tr>\n<tr><th class=\"sub conditions_header\" scope=\"row\">Diluent:<\/th><td>Ethyl acetate<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Conc.:<\/th><td>20 \u00b5g\/mL<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Injection<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Vol.:<\/th><td>1 \u00b5L split (split ratio 10:1)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Liner:<\/th><td>Topaz, splitless, single taper inlet liner, 4.0 mm x 6.5 x 78.5 (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/23303?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_GN1244\" rel=\"noopener\">cat.# 23303<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Temp.:<\/th><td>280 \u00b0C<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Carrier Gas<\/th><td>He<\/td><\/tr><\/table><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Detector<\/th><td>MS<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Mode:<\/th><td>Scan<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Transfer Line Temp.:<\/th><td>300 \u00b0C<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Analyzer Type:<\/th><td>Quadrupole <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Source Temp.:<\/th><td>230 \u00b0C<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Quad Temp.:<\/th><td>150 \u00b0C<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Electron Energy:<\/th><td>70 eV<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Tune Type:<\/th><td>PFTBA <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ionization Mode:<\/th><td>EI <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Instrument<\/th><td>Agilent 7890B GC &amp; 5977A MSD<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Sample Preparation<\/th><td>The standards were diluted with ethyl acetate to 20 ppm; analyzed in a 2 mL, short-cap, screw-thread vial (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/21143?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_GN1244\" rel=\"noopener\">cat.# 21143<\/a>); and capped with a short-cap, screw-vial closure (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/24495?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_GN1244\" rel=\"noopener\">cat.# 24495<\/a>).<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Notes<\/th><td><b> Conventional (30 m) Analysis:<\/b><br \/>Column: Rxi-35Sil MS, 30 m, 0.25 mm ID, 0.25 \u00b5m (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/13823?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_GN1244\" rel=\"noopener\">cat.# 13823<\/a>)<br \/>Temp. program: 200 \u00b0C (hold 0.5 min) to 320 \u00b0C at 9.5 \u00b0C\/min (hold 5 min)<br \/>Flow: 2.0 mL\/min<br \/>Scan start time: 2 min<br \/>Scan range: 30-300 amu<br \/>Scan rate: 10 scans\/sec<br \/><br \/><b>LPGC-MS Analysis:<\/b><br \/>Column: LPGC Rxi-35Sil MS column kit, includes 10 m x 0.32 mm ID x 0.25 \u03bcm Rxi-35Sil MS analytical column and 5 m x 0.15 mm ID Rxi restrictor factory connected via SilTite connector (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/11806?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_GN1244\" rel=\"noopener\">cat.# 11806<\/a>)<br \/>Temp. program: 100 \u00b0C (hold 0.5 min) to 300 \u00b0C at 35 \u00b0C\/min (hold 5 min)<br \/>Flow: 0.9 mL\/min<br \/>Scan start time: 1 min<br \/>Scan range: 35-300 amu<br \/>Scan rate: 9.7 scans\/sec<br \/><br \/>Compound list based on EU legislation of Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) Appendix 8 (https:\/\/reachonline.eu\/reach\/en\/appendix-8.html). The 3-chloro-o-toluidine and 2-aminibiphenyl compounds are not part of the list.<\/td><\/tr><\/table><\/div><\/div><\/div><div class=\"chromatogram-pdf-link\"><a href=\"https:\/\/ez.restek.com\/images\/cgram\/gc_gn1244.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"18\" height=\"18\" viewBox=\"0 0 18 18\"><g data-name=\"Group 2996\"><path data-name=\"Rectangle 1246\" d=\"M0 0h18v18H0z\" style=\"fill: none;\"><\/path><\/g><g data-name=\"Group 2997\"><path data-name=\"Path 729\" d=\"M13.412 11.4v2.017H5.345V11.4H4v2.017a1.349 1.349 0 0 0 1.345 1.345h8.068a1.349 1.349 0 0 0 1.345-1.345V11.4zm-.672-2.694-.948-.948-1.741 1.735V4H8.706v5.493L6.965 7.758l-.948.948 3.361 3.361z\" transform=\"translate(-.437 -.414)\" style=\"fill: rgb(13, 123, 196);\"><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n        <div class=\"cpb\">\n            <h3 class=\"cpb-heading\">Products Mentioned<\/h3>\n            <hr class=\"cpb-heading-underline\" \/>\n            <div class=\"cpb-list\">\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/de.restek.com\/p\/11806\">                                Catalog No. 11806                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">LPGC Rxi-35Sil MS S\u00e4ulenkit<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/de.restek.com\/p\/11806\">Produkt anzeigen<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/de.restek.com\/p\/23849\">                                Catalog No. 23849                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">GC Accelerator-Ofeneinsatz-Kit, f\u00fcr Agilent 5890, 6890, 7890 und 8890 GCs<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/de.restek.com\/p\/23849\">Produkt anzeigen<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/de.restek.com\/p\/23303\">                                Catalog No. 23303                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Topaz, Single Taper Inlet Liner, 4.0 mm x 6.5 x 78.5, f\u00fcr Agilent GCs, mit Quarzwolle, Premium-Deaktivierung, 5er Pack<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/de.restek.com\/p\/23303\">Produkt anzeigen<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/de.restek.com\/p\/21143\">                                Catalog No. 21143                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Short-Cap-Vial mit graduiertem Markierungsfeld, 9-425 Screw-Thread, 2.0 mL, 9 mm, 12 x 32 (nur Vial), braun, 1000er Pack<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/de.restek.com\/p\/21143\">Produkt anzeigen<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/de.restek.com\/p\/24495\">                                Catalog No. 24495                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Short Screw Kappen, Polypropylen, Screw-Thread, PTFE\/Silikon\/PTFE Septen, schwarz, vormontiert, 2.0 mL, 9 mm, 100er Pack<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/de.restek.com\/p\/24495\">Produkt anzeigen<\/a>\n                                                    <\/div>\n                    <\/div>\n                            <\/div>\n        <\/div>\n        \n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Analyze arylamines 3.3x faster using 81% less helium with this low-pressure GC-MS (LPGC-MS) method and Restek\u2019s pre-connected LPGC Rxi-35Sil MS column 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