{"id":51683,"date":"2020-11-26T00:00:00","date_gmt":"2020-11-26T00:00:00","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/fda-warns-hand-sanitizers-may-contain-1-propanol\/"},"modified":"2025-11-20T21:50:37","modified_gmt":"2025-11-20T21:50:37","slug":"fda-warns-hand-sanitizers-may-contain-1-propanol","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/de\/blogs\/gnbl4665\/fda-warns-hand-sanitizers-may-contain-1-propanol","title":{"rendered":"FDA Warns Hand Sanitizers May Contain 1-Propanol"},"content":{"rendered":"\n

The Food and Drug Administration (FDA) has expanded their recall of hand sanitizers and found more chemical contaminants to include 1-propanol (n-propanol cas# 71-23-8). 2-propanol (isopropanol cas# 67-63-0) and Ethanol (cas# 64-17-5) are the two most widely used active ingredients in hand sanitizers. With this latest addition to the list, the main concern for exposure is ingestion (1). In a three-year period over 60,000 children under 12 years old ingested hand sanitizer (2). 1-propanol is metabolized via the enzyme alcohol dehydrogenase to propionic acid and thereby disrupts the pH balance of the blood, while 2-propanol is metabolized with the same enzyme, however, the product is acetone leading to ketosis. Ingestion of both alcohols results in 1-propanol slowing down the breakdown of 2-proponal to acetone prolonging the sickness (3).<\/p>\n\n\n\n

Our previous\u00a0blog<\/a>\u00a0addressed the recall of hand sanitizers that may contain methanol. Using the same method conditions it’s possible to analyze 1-propanol in addition to other compounds commonly found in adulterated hand sanitizer (Figure 1). Following the conditions below, we recommend eliminating 1-propanol as a co-solvent in the rinse vial and substituting acetonitrile instead. Figure 2 shows 1-propanol can be found as a contaminant in the blanks and samples.<\/p>\n\n\n\n


\"diagram\"
Figure 1: The analysis of denatured alcohol with an overlayed chromatogram of 1-propanol. It is possible to analyze for a variety of alcohols in hand sanitizer at percent levels using the Rtx-VMS.<\/p>\n\n\n\n

\"text\"
Figure 2: Trace amounts of 1-propanol can be found in samples and blanks when using 10% 1-propanol as a post rinse (see red text). Changing the co-solvent to a non-target compound is recommended.<\/p>\n\n\n\n

1  https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-updates-hand-sanitizers-consumers-should-not-use<\/a> <\/p>\n\n\n\n

2 https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0099176718304884<\/a><\/p>\n\n\n\n

3 https:\/\/pubmed.ncbi.nlm.nih.gov\/18375643\/<\/a><\/p>\n\n\n\n

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The Food and Drug Administration (FDA) has expanded their recall of hand sanitizers and found more chemical contaminants to include 1-propanol (n-propanol cas# 71-23-8). 2-propanol (isopropanol cas# 67-63-0) and Ethanol (cas# 64-17-5) are the two most widely used active ingredients…<\/p>\n","protected":false},"author":21,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[9],"tags":[],"industries-application":[],"post-badge":[],"resource-type":[],"product-library":[],"resource-technique":[2294,2301],"ppma_author":[441],"class_list":["post-51683","post","type-post","status-publish","format-standard","hentry","category-blogs","resource-technique-gas-chromatography-gc","resource-technique-mass-spectrometry-ms"],"acf":[],"taxonomy_info":{"category":[{"value":9,"label":"Blogs"}],"resource-technique":[{"value":2294,"label":"Gas Chromatography (GC)"},{"value":2301,"label":"Mass Spectrometry (MS)"}]},"featured_image_src_large":false,"author_info":{"display_name":"Chris English","author_link":"https:\/\/discover.restek.com\/de\/author\/chris-english\/"},"comment_info":0,"category_info":[{"term_id":9,"name":"Blogs","slug":"blogs","term_group":0,"term_taxonomy_id":9,"taxonomy":"category","description":"","parent":0,"count":437,"filter":"raw","cat_ID":9,"category_count":437,"category_description":"","cat_name":"Blogs","category_nicename":"blogs","category_parent":0}],"tag_info":false,"authors":[{"term_id":441,"user_id":21,"is_guest":0,"slug":"chris-english","display_name":"Chris English","avatar_url":{"url":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-english-chris.png","url2x":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-english-chris.png"},"author_category":"1","first_name":"Chris","last_name":"English","user_url":"https:\/\/www.linkedin.com\/in\/chris-english-28214912\/","job_title":"Sr. R&D Manager","description":"Since 2004, Chris has managed a team of chemists in Restek's innovations laboratory who perform new product testing, method development, and applications work. Before taking the reins of our lab, he spent seven years as an environmental chemist and was critical to the development of Restek\u2019s current line of volatile GC columns. Prior to joining Restek, he operated a variety of gas chromatographic detectors conducting method development and sample analysis. Chris holds a BS in environmental science from Saint Michael's College."}],"_links":{"self":[{"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/posts\/51683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/comments?post=51683"}],"version-history":[{"count":3,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/posts\/51683\/revisions"}],"predecessor-version":[{"id":66945,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/posts\/51683\/revisions\/66945"}],"wp:attachment":[{"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/media?parent=51683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/categories?post=51683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/tags?post=51683"},{"taxonomy":"industries-application","embeddable":true,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/industries-application?post=51683"},{"taxonomy":"post-badge","embeddable":true,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/post-badge?post=51683"},{"taxonomy":"resource-type","embeddable":true,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/resource-type?post=51683"},{"taxonomy":"product-library","embeddable":true,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/product-library?post=51683"},{"taxonomy":"resource-technique","embeddable":true,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/resource-technique?post=51683"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/discover.restek.com\/de\/wp-json\/wp\/v2\/ppma_author?post=51683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}