{"id":76444,"date":"2022-05-25T00:00:00","date_gmt":"2022-05-25T00:00:00","guid":{"rendered":"https:\/\/discover.restek.com\/?p=76444"},"modified":"2025-12-26T19:17:06","modified_gmt":"2025-12-26T19:17:06","slug":"new-ezgc-library-residual-solvents-on-the-rtx-225","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/es\/blogs\/gnbl5520\/new-ezgc-library-residual-solvents-on-the-rtx-225","title":{"rendered":"New EZGC library: Residual solvents on the Rtx-225"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">The Rtx-225 is a versatile column with unique selectivity for low-boiling-point compounds. &nbsp;The cyano-phenyl composition of this phase limits the maximum operating temperature to &lt;240\u00b0C.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To help figure out if this column will work for your analytes of interest, a new residual solvents library has been added to EZGC, containing compounds from all three solvent classes designated by the USP and ICH&nbsp;<sup>1,2<\/sup>&nbsp;(Table 1).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Table 1:<\/strong>&nbsp;Residual solvents included in the Rtx-225 EZGC library.<\/p>\n\n\n\n<figure class=\"wp-block-table table\"><table><tbody><tr><td>\n<p>Chemical:<\/p>\n<\/td><td>\n<p>CAS (#)<\/p>\n<\/td><td>\n<p>Class (#)<\/p>\n<\/td><\/tr><tr><td>\n<p>Benzene<\/p>\n<\/td><td>\n<p>71-43-2<\/p>\n<\/td><td>\n<p>1<\/p>\n<\/td><\/tr><tr><td>\n<p>Chloroform<\/p>\n<\/td><td>\n<p>67-66-3<\/p>\n<\/td><td>\n<p>1<\/p>\n<\/td><\/tr><tr><td>\n<p>Trichloroethene<\/p>\n<\/td><td>\n<p>79-01-6<\/p>\n<\/td><td>\n<p>1<\/p>\n<\/td><\/tr><tr><td>\n<p>1,4-Dioxane<\/p>\n<\/td><td>\n<p>123-91-1<\/p>\n<\/td><td>\n<p>2<\/p>\n<\/td><\/tr><tr><td>\n<p>Chlorobenzene<\/p>\n<\/td><td>\n<p>108-90-7<\/p>\n<\/td><td>\n<p>2<\/p>\n<\/td><\/tr><tr><td>\n<p>cis-1,2-Dichloroethene (Z)<\/p>\n<\/td><td>\n<p>156-59-2<\/p>\n<\/td><td>\n<p>2<\/p>\n<\/td><\/tr><tr><td>\n<p>Cyclohexane<\/p>\n<\/td><td>\n<p>110-82-7<\/p>\n<\/td><td>\n<p>2<\/p>\n<\/td><\/tr><tr><td>\n<p>Ethylbenzene<\/p>\n<\/td><td>\n<p>100-41-4<\/p>\n<\/td><td>\n<p>2<\/p>\n<\/td><\/tr><tr><td>\n<p>m\/p-Xylene<\/p>\n<\/td><td>\n<p>108-38-3<\/p>\n<\/td><td>\n<p>2<\/p>\n<\/td><\/tr><tr><td>\n<p>Methylcyclohexane<\/p>\n<\/td><td>\n<p>108-87-2<\/p>\n<\/td><td>\n<p>2<\/p>\n<\/td><\/tr><tr><td>\n<p>o-Xylene<\/p>\n<\/td><td>\n<p>95-47-6<\/p>\n<\/td><td>\n<p>2<\/p>\n<\/td><\/tr><tr><td>\n<p>Tetrahydrofuran<\/p>\n<\/td><td>\n<p>109-99-9<\/p>\n<\/td><td>\n<p>2<\/p>\n<\/td><\/tr><tr><td>\n<p>Toluene<\/p>\n<\/td><td>\n<p>108-88-3<\/p>\n<\/td><td>\n<p>2<\/p>\n<\/td><\/tr><tr><td>\n<p>trans-1,2-Dichloroethene (E)<\/p>\n<\/td><td>\n<p>156-60-5<\/p>\n<\/td><td>\n<p>2<\/p>\n<\/td><\/tr><tr><td>\n<p>1-Butanol<\/p>\n<\/td><td>\n<p>71-36-3<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>1-Pentanol<\/p>\n<\/td><td>\n<p>71-41-0<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>1-Propanol<\/p>\n<\/td><td>\n<p>71-23-8<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>2-Butanol (sec-butyl alcohol)<\/p>\n<\/td><td>\n<p>78-92-2<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>2-Butanone (MEK)<\/p>\n<\/td><td>\n<p>78-93-3<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>2-Propanol (isopropanol)<\/p>\n<\/td><td>\n<p>67-63-0<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>3-Methyl-1-butanol (isoamyl alcohol)<\/p>\n<\/td><td>\n<p>123-51-3<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>4-Methyl-2-pentanone (MIBK)<\/p>\n<\/td><td>\n<p>108-10-1<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>Butyl acetate<\/p>\n<\/td><td>\n<p>123-86-4<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>Diethyl ether (ethyl ether)<\/p>\n<\/td><td>\n<p>60-29-7<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>Ethanol<\/p>\n<\/td><td>\n<p>64-17-5<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>Ethyl acetate<\/p>\n<\/td><td>\n<p>141-78-6<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>Ethyl formate<\/p>\n<\/td><td>\n<p>109-94-4<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>Isobutanol (2-methyl-1-propanol)<\/p>\n<\/td><td>\n<p>78-83-1<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>Isobutyl acetate (acetic acid 2-methylpropyl ester)<\/p>\n<\/td><td>\n<p>108-21-4<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>Isopropyl acetate (acetic acid, 1-methylethyl ester)<\/p>\n<\/td><td>\n<p>108-21-4<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>Methyl acetate<\/p>\n<\/td><td>\n<p>79-20-9<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>Methyl-tert-butyl ether (MTBE)<\/p>\n<\/td><td>\n<p>1634-04-4<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><tr><td>\n<p>Propyl acetate<\/p>\n<\/td><td>\n<p>109-60-4<\/p>\n<\/td><td>\n<p>3<\/p>\n<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Using EZGC, we were able to build a method that could separate 25 of the 33 compounds in under 5 minutes (Figure 1).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Figure 1<\/strong>: EZGC method predictions for separation of class 1-3 residual solvents.<\/p>\n\n\n<style>.kb-image76444_44a08a-af:not(.kb-image-is-ratio-size) .kb-img, .kb-image76444_44a08a-af.kb-image-is-ratio-size{padding-top:var(--global-kb-spacing-xs, 1rem);padding-bottom:var(--global-kb-spacing-xs, 1rem);}.kb-image76444_44a08a-af .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<figure class=\"wp-block-kadence-image kb-image76444_44a08a-af size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"678\" height=\"1272\" src=\"https:\/\/discover.restek.com\/wp-content\/uploads\/blog-new-ezgc-library-residual-solvents-on-the-rtx-225-01.png\" alt=\"\" class=\"kb-img wp-image-78385\" title=\"-\" srcset=\"https:\/\/discover.restek.com\/wp-content\/uploads\/blog-new-ezgc-library-residual-solvents-on-the-rtx-225-01.png 678w, https:\/\/discover.restek.com\/wp-content\/uploads\/blog-new-ezgc-library-residual-solvents-on-the-rtx-225-01-160x300.png 160w, https:\/\/discover.restek.com\/wp-content\/uploads\/blog-new-ezgc-library-residual-solvents-on-the-rtx-225-01-546x1024.png 546w\" sizes=\"auto, (max-width: 678px) 100vw, 678px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Our column was measured to be 29.09m. We used an inlet temperature of 250<sup>o<\/sup>C, Topaz straight inlet liner with wool (cat#23300), and a 400:1 split injection. The standards used were cat# 36004 (class 1), 36217 (class 2), 36013 (class 3).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Even though we had quite a few coelutions, the use of a mass-spectrometers helped to identify individual peaks for all 33 compounds. If you are also using a mass-spectrometer, the EZGC chromatogram modeler can help you to select unique ions differentiating co-eluting peaks, saving valuable trial-and-error time.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>For further reading:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Impurities: Guideline for Residual Solvents Q3C(R8). International council for harmonisation of technical requirements for pharmaceuticals for human use April 22, 2021.<\/li>\n\n\n\n<li>&lt;467> RESIDUAL SOLVENTS. United States Pharmacopia March 23, 2007.<\/li>\n<\/ol>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The Rtx-225 is a versatile column with unique selectivity low-boiling-point compounds. &nbsp;The cyano-phenyl composition of this phase limits the maximum operating temperature to &lt;240&deg;C.&nbsp;<br \/>To help figure out if this column will work for your analytes of interest, a new residual solvents library has been added to EZGC, containing compounds from all three solvent classes designated by the USP and ICH 1,2.<\/p>\n","protected":false},"author":34,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[9],"tags":[],"industries-application":[],"post-badge":[],"resource-type":[],"product-library":[],"resource-technique":[],"ppma_author":[454],"class_list":["post-76444","post","type-post","status-publish","format-standard","hentry","category-blogs"],"acf":[],"taxonomy_info":{"category":[{"value":9,"label":"Blogs"}]},"featured_image_src_large":false,"author_info":{"display_name":"Erica Pack, PhD","author_link":"https:\/\/discover.restek.com\/es\/author\/erica-pack-phd\/"},"comment_info":0,"category_info":[{"term_id":9,"name":"Blogs","slug":"blogs","term_group":0,"term_taxonomy_id":9,"taxonomy":"category","description":"","parent":0,"count":437,"filter":"raw","cat_ID":9,"category_count":437,"category_description":"","cat_name":"Blogs","category_nicename":"blogs","category_parent":0}],"tag_info":false,"authors":[{"term_id":454,"user_id":34,"is_guest":0,"slug":"erica-pack-phd","display_name":"Erica Pack, PhD","avatar_url":{"url":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-pack-erica.jpg","url2x":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-pack-erica.jpg"},"author_category":"1","first_name":"Erica","last_name":"Pack","user_url":"https:\/\/www.linkedin.com\/in\/ericapack\/","job_title":"","description":"Erica is an interdisciplinary GC applications and technologies scientist at Restek. She obtained her bachelor's degree in forensic biology from The Pennsylvania State University, and her doctorate from Virginia Tech in plant pathology, physiology, and weed science. Since joining Restek in 2021, she has worked with a wide variety of GC columns, including fused silica, MXT, PLOT, and packed columns as well as accessories, such as liners, valves, and methanizers."}],"_links":{"self":[{"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/posts\/76444","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/users\/34"}],"replies":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/comments?post=76444"}],"version-history":[{"count":4,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/posts\/76444\/revisions"}],"predecessor-version":[{"id":78396,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/posts\/76444\/revisions\/78396"}],"wp:attachment":[{"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/media?parent=76444"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/categories?post=76444"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/tags?post=76444"},{"taxonomy":"industries-application","embeddable":true,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/industries-application?post=76444"},{"taxonomy":"post-badge","embeddable":true,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/post-badge?post=76444"},{"taxonomy":"resource-type","embeddable":true,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/resource-type?post=76444"},{"taxonomy":"product-library","embeddable":true,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/product-library?post=76444"},{"taxonomy":"resource-technique","embeddable":true,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/resource-technique?post=76444"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/discover.restek.com\/es\/wp-json\/wp\/v2\/ppma_author?post=76444"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}