Column temperature can impact peak shape, retention, and backpressure. Sometimes it can even affect the column’s ability to resolve certain analytes. In this post, we ask whether your LC column temperature should be controlled and look at the various methods available to do so.
I recently spoke to a customer who said she was having a difficult time finding the catalog number of the column she was trying to order. I asked for the catalog number, and she provided 70112-6850. I instantly knew what…
If your chromatography degrades quickly after injecting samples (or standards) that contain matrix, the following suggestions may help increase the numbers of injections before routine maintenance (trimming the column, replacing the injection port liner, cleaning the injection port, etc.) is needed.
The primary goal of the GC oven temperature program is to maximize the peak capacity of our chromatogram. Temperature programming, when paired with constant flow (pressure programmed GC) allows us to maintain sharp narrow peaks throughout the entire chromatographic run.
Cooking, or the process of heating up foodstuffs, leads to diverse chemical reactions that permit the development of aroma and a richer food taste, facilitate food preservation, and in many cases…
Please note that (generally speaking) Restek does not recommend using any particle-containing GC column when using a mass spectrometer as the detector. Particles will likely make their way into the detector/pumps even with a particle trap installed. However, if you do plan to use a PLOT column with a mass spec, you should consider the suggestions below to minimize the number of particles which may make their way into your detector.
This application note details a fast, 3.5-minute LC-MS/MS method for quantitative analysis of psilocin and psilocybin in human urine.
At Restek, we understand that cannabis testing labs demand reliable information to help them make the right choices when developing robust methods capable of complying with stringent regulations. With this in mind, we developed a simple approach for the determination of pesticides, mycotoxins, and cannabinoids in chocolate samples.
Model more than 60 common inhalants of abuse and develop methods within minutes, without taking your instrument offline.
Two of my RESTEK colleagues, Landon Wiest and Jana Hepner, have posted parts one Pesticides are like Siblings – some get along well and some don’t – No. . .Really? and two Pesticides are like Siblings, They Don’t Always Get Along part 2 – now with the GC mix! on this topic showing what happens to the 200+ pesticides in our LC and GC multiresidue CRM kits when the mixes are all combined together into a single mixture then used to detect pesticides in celery matrix. Both confirmed with their study results that once pesticides ampules are mixed together and stored for a number of days some pesticides degraded immediately while others degraded over a longer timeframe.
