Reducing Column Internal Diameter
Scaling down column size is simple to do and can help reduce solvent use. Here is an easy-to-follow example that teaches you how to reduce column internal diameter.
A Primer on Gas Flow
A basic understanding of gas flow principles is fundamental to obtaining accurate flow measurements. This primer contrasts mass flow and volumetric flow regimes, and illustrates the effect of flow impedance and loading on the flow source in gas chromatography.
Sulfinert-Treated Sample Cylinders
Recovery of a 17 ppbv test standard of hydrogen sulfide exceeded 85% after 54 hours in a Sulfinert-treated cylinder; recoveries of methyl mercaptan, ethyl mercaptan, carbonyl sulfide, and dimethyl disulfide exceeded 90%. A Sulfinert-treated sampling/transfer system can assure accurate sulfur content data for natural gas, beverage-grade carbon dioxide, or other samples.
Analysis of Synthetic Cannabinoids and Metabolites: Adding New Compounds to an Existing LC-MS/MS Method
The analysis of synthetic cannabinoids and their metabolites can be a difficult and challenging task. Keeping up with the ever-growing list of synthetic cannabinoids that illicit drugmakers produce further complicates the analysis. As shown here, the retention and selectivity of the Raptor Biphenyl column allows new drugs to be added to an existing method, providing labs with an important vehicle for improving efficiency and productivity.
Successful Strategies for the Analysis of EtG and EtS in Urine
LC-MS/MS analysis of EtG and EtS is challenging due primarily to poor retention and resolution of EtG and EtS from matrix components. This article presents a foundation method that is useful for many samples and also demonstrates effective strategies for improving sensitivity and mitigating matrix effects.
“The Big Pain“: Development of Pain-Free Methods for Analyzing 231 Multiclass Drugs and Metabolites by LC-MS/MS
As the demand for testing of pain management drugs increases, many laboratories are turning to LC-MS/MS for its increased speed, sensitivity, and specificity. The methods shown here use a Raptor Biphenyl column because it provides fast, accurate analysis of 231 drugs and drug metabolites.
Evaluation of a Simple Method for Methylmalonic Acid Analysis in Human Plasma by LC-MS/MS
A new LC-MS/MS method for methylmalonic acid (MMA) analysis was developed that provides complete chromatographic resolution from isobaric succinic acid in plasma samples. Excellent chromatographic results were obtained from the direct injection of a protein crash sample supernatant onto a Force C18 column, providing a much simpler sample preparation compared to typical methods.
Hydrocarbon Ranges of Natural Gas and Petroleum Products
Sometimes customers need to analyze natural gas and petroleum products, whether it is to confirm the purity of the product by looking for the impurities which may be present, or for an environmental reason such as a spill or leak….
Over tightening your fittings has consequences.
If you use the correct fittings and seals in the gas chromatography system, and follow some simple steps, there is absolutely no need to over tighten any fitting to achieve a leak free seal. For almost all fittings that use…
What impurities are hiding in your monocyclic aromatic solvents?
As we approach the end of the year we are indulging in a bit of nostalgia and most experts agree that reminiscing about the past is a good thing1. It makes us more optimistic and generous. Researchers also noticed that…
