{"id":51683,"date":"2020-11-26T00:00:00","date_gmt":"2020-11-26T00:00:00","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/fda-warns-hand-sanitizers-may-contain-1-propanol\/"},"modified":"2025-11-20T21:50:37","modified_gmt":"2025-11-20T21:50:37","slug":"fda-warns-hand-sanitizers-may-contain-1-propanol","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/fr\/blog-it\/gnbl4665\/fda-warns-hand-sanitizers-may-contain-1-propanol","title":{"rendered":"FDA Warns Hand Sanitizers May Contain 1-Propanol"},"content":{"rendered":"\n

The Food and Drug Administration (FDA) has expanded their recall of hand sanitizers and found more chemical contaminants to include 1-propanol (n-propanol cas# 71-23-8). 2-propanol (isopropanol cas# 67-63-0) and Ethanol (cas# 64-17-5) are the two most widely used active ingredients in hand sanitizers. With this latest addition to the list, the main concern for exposure is ingestion (1). In a three-year period over 60,000 children under 12 years old ingested hand sanitizer (2). 1-propanol is metabolized via the enzyme alcohol dehydrogenase to propionic acid and thereby disrupts the pH balance of the blood, while 2-propanol is metabolized with the same enzyme, however, the product is acetone leading to ketosis. Ingestion of both alcohols results in 1-propanol slowing down the breakdown of 2-proponal to acetone prolonging the sickness (3).<\/p>\n\n\n\n

Our previous\u00a0blog<\/a>\u00a0addressed the recall of hand sanitizers that may contain methanol. Using the same method conditions it’s possible to analyze 1-propanol in addition to other compounds commonly found in adulterated hand sanitizer (Figure 1). Following the conditions below, we recommend eliminating 1-propanol as a co-solvent in the rinse vial and substituting acetonitrile instead. Figure 2 shows 1-propanol can be found as a contaminant in the blanks and samples.<\/p>\n\n\n\n


\"diagram\"
Figure 1: The analysis of denatured alcohol with an overlayed chromatogram of 1-propanol. It is possible to analyze for a variety of alcohols in hand sanitizer at percent levels using the Rtx-VMS.<\/p>\n\n\n\n

\"text\"
Figure 2: Trace amounts of 1-propanol can be found in samples and blanks when using 10% 1-propanol as a post rinse (see red text). Changing the co-solvent to a non-target compound is recommended.<\/p>\n\n\n\n

1  https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-updates-hand-sanitizers-consumers-should-not-use<\/a> <\/p>\n\n\n\n

2 https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0099176718304884<\/a><\/p>\n\n\n\n

3 https:\/\/pubmed.ncbi.nlm.nih.gov\/18375643\/<\/a><\/p>\n\n\n\n

<\/div>\n\n\n
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Products Mentioned<\/h3>\n
\n
\n
\n
\n Catalog No. 19915 <\/a> <\/div>\n
\n
Colonne capillaire Rtx-VMS, L 30 m, DI 0.25 mm, 1.40 \u00b5m<\/div>\n <\/div>\n
\n Voir le produit<\/a>\n <\/div>\n <\/div>\n
\n
\n Catalog No. 23305 <\/a> <\/div>\n
\n
Insert Topaz Precision, 4.0\u00a0mm x 6.3 x 78.5, pour GC Agilent, avec laine de quartz, d\u00e9sactivation Premium, lot de 5<\/div>\n <\/div>\n
\n Voir le produit<\/a>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n \n\n\n
<\/div>\n","protected":false},"excerpt":{"rendered":"

The Food and Drug Administration (FDA) has expanded their recall of hand sanitizers and found more chemical contaminants to include 1-propanol (n-propanol cas# 71-23-8). 2-propanol (isopropanol cas# 67-63-0) and Ethanol (cas# 64-17-5) are the two most widely used active ingredients…<\/p>\n","protected":false},"author":21,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[793],"tags":[],"industries-application":[],"post-badge":[],"resource-type":[],"product-library":[],"resource-technique":[2332,2336],"hf_cat_post":[623],"ppma_author":[441],"class_list":["post-51683","post","type-post","status-publish","format-standard","hentry","category-blog-it","resource-technique-gascromatografia-gc","resource-technique-spettometria-di-massa-ms"],"acf":[],"taxonomy_info":{"category":[{"value":793,"label":"Blog"}],"resource-technique":[{"value":2332,"label":"Gascromatografia (GC)"},{"value":2336,"label":"Spettometria di Massa (MS)"}]},"featured_image_src_large":false,"author_info":{"display_name":"Chris English","author_link":"https:\/\/discover.restek.com\/fr\/author\/chris-english\/"},"comment_info":0,"category_info":[{"term_id":793,"name":"Blog","slug":"blog-it","term_group":0,"term_taxonomy_id":793,"taxonomy":"category","description":"","parent":0,"count":442,"filter":"raw","cat_ID":793,"category_count":442,"category_description":"","cat_name":"Blog","category_nicename":"blog-it","category_parent":0}],"tag_info":false,"authors":[{"term_id":441,"user_id":21,"is_guest":0,"slug":"chris-english","display_name":"Chris English","avatar_url":{"url":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-english-chris.png","url2x":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-english-chris.png"},"0":null,"1":"","2":"","3":"","4":"","5":"","6":"","7":"","8":""}],"_links":{"self":[{"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/posts\/51683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/comments?post=51683"}],"version-history":[{"count":3,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/posts\/51683\/revisions"}],"predecessor-version":[{"id":66945,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/posts\/51683\/revisions\/66945"}],"wp:attachment":[{"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/media?parent=51683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/categories?post=51683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/tags?post=51683"},{"taxonomy":"industries-application","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/industries-application?post=51683"},{"taxonomy":"post-badge","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/post-badge?post=51683"},{"taxonomy":"resource-type","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/resource-type?post=51683"},{"taxonomy":"product-library","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/product-library?post=51683"},{"taxonomy":"resource-technique","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/resource-technique?post=51683"},{"taxonomy":"hf_cat_post","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/hf_cat_post?post=51683"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/ppma_author?post=51683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}