{"id":89274,"date":"2026-03-03T20:30:06","date_gmt":"2026-03-03T20:30:06","guid":{"rendered":"https:\/\/discover.restek.com\/?p=89274"},"modified":"2026-03-04T20:53:13","modified_gmt":"2026-03-04T20:53:13","slug":"semisynthetic-cannabinoids-the-newest-challenge-in-analyzing-thc-isomers","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/fr\/posters-presentations\/gnot5637\/semisynthetic-cannabinoids-the-newest-challenge-in-analyzing-thc-isomers","title":{"rendered":"Semisynthetic Cannabinoids: The Newest Challenge in Analyzing THC Isomers"},"content":{"rendered":"\n<p>Over the past several years, \u03948-THC has made headlines as a popular \u201clegal\u201d alternative to \u03949-THC. The rise in popularity of \u03948-THC led to a new analytical challenge for toxicology laboratories\u2014differentiating between the \u03948 and \u03949 isomer forms. For labs performing this testing by LC-MS\/MS, complete separation of the isomers and their metabolites is necessary for accurate quantitation. While HPLC stationary phases like Biphenyl and C18 have traditionally been used for toxicological analysis of cannabinoids, they lack the selectivity needed to adequately separate these isomers. FluoroPhenyl phase columns have emerged as a superior choice for analyzing THC isomers in biological matrices due to their unique selectivity capabilities.<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/discover.restek.com\/wp-content\/uploads\/poster-AAFS-2026-Semi-Synthetic-Cannabinoids-Poster.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of poster-AAFS-2026-Semi-Synthetic Cannabinoids Poster.\"><\/object><a id=\"wp-block-file--media-4301714e-2cfe-4c89-83ab-44c822ae7fd9\" href=\"https:\/\/discover.restek.com\/wp-content\/uploads\/poster-AAFS-2026-Semi-Synthetic-Cannabinoids-Poster.pdf\">poster-AAFS-2026-Semi-Synthetic Cannabinoids Poster<\/a><a href=\"https:\/\/discover.restek.com\/wp-content\/uploads\/poster-AAFS-2026-Semi-Synthetic-Cannabinoids-Poster.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-4301714e-2cfe-4c89-83ab-44c822ae7fd9\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Over the past several years, \u03948-THC has made headlines as a popular \u201clegal\u201d alternative to \u03949-THC. The rise in popularity of \u03948-THC led to a new analytical challenge for toxicology laboratories\u2014differentiating between the \u03948 and \u03949 isomer forms. For labs performing this testing by LC-MS\/MS, complete separation of the isomers and their metabolites is necessary for accurate quantitation. While HPLC stationary phases like Biphenyl and C18 have traditionally been used for toxicological analysis of cannabinoids, they lack the selectivity needed to adequately separate these isomers. FluoroPhenyl phase columns have emerged as a superior choice for analyzing THC isomers in biological matrices due to their unique selectivity capabilities.<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[12],"tags":[],"industries-application":[],"post-badge":[],"resource-type":[],"product-library":[],"resource-technique":[],"hf_cat_post":[],"ppma_author":[414],"class_list":["post-89274","post","type-post","status-publish","format-standard","hentry","category-posters-presentations"],"acf":[],"taxonomy_info":{"category":[{"value":12,"label":"Posters &amp; Presentations"}]},"featured_image_src_large":false,"author_info":{"display_name":"Restek Corporation","author_link":"https:\/\/discover.restek.com\/fr\/author\/restek-corporation\/"},"comment_info":0,"category_info":[{"term_id":12,"name":"Posters &amp; Presentations","slug":"posters-presentations","term_group":0,"term_taxonomy_id":12,"taxonomy":"category","description":"","parent":0,"count":118,"filter":"raw","cat_ID":12,"category_count":118,"category_description":"","cat_name":"Posters &amp; Presentations","category_nicename":"posters-presentations","category_parent":0}],"tag_info":false,"authors":[{"term_id":414,"user_id":11,"is_guest":0,"slug":"restek-corporation","display_name":"Restek Corporation","avatar_url":{"url":"https:\/\/discover.restek.com\/wp-content\/uploads\/Restek_Favicon_300x300.jpg","url2x":"https:\/\/discover.restek.com\/wp-content\/uploads\/Restek_Favicon_300x300.jpg"},"0":null,"1":"","2":"","3":"","4":"","5":"","6":"","7":"","8":""}],"_links":{"self":[{"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/posts\/89274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/comments?post=89274"}],"version-history":[{"count":3,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/posts\/89274\/revisions"}],"predecessor-version":[{"id":89435,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/posts\/89274\/revisions\/89435"}],"wp:attachment":[{"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/media?parent=89274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/categories?post=89274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/tags?post=89274"},{"taxonomy":"industries-application","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/industries-application?post=89274"},{"taxonomy":"post-badge","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/post-badge?post=89274"},{"taxonomy":"resource-type","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/resource-type?post=89274"},{"taxonomy":"product-library","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/product-library?post=89274"},{"taxonomy":"resource-technique","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/resource-technique?post=89274"},{"taxonomy":"hf_cat_post","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/hf_cat_post?post=89274"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/discover.restek.com\/fr\/wp-json\/wp\/v2\/ppma_author?post=89274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}