Cartridge size should be selected based on sample volume while the bed weight of the packing is determined by the compound load (analytes of interest and interferences). Choose the SPE cartridge that is best for your application based on the following table.
| Sample Volume | Compound Load | Cartridge Size | Bed Weight |
| 1-10 mL | 2-6 mg | 1 mL | 100-300 mg |
| 10-100 mL | 6-1000 mg | 3 mL | 300-500 mg |
| 100 mL – 1 L | >1000 mg | 6 mL | >500 mg |
If the sample volume exceeds the capacity of the SPE cartridge being used, then a larger, empty SPE cartridge can be used along with a connector to hold the additional volume. Alternatively, the Resprep Sample Delivery System can be used.
