{"id":43501,"date":"2025-10-03T21:16:53","date_gmt":"2025-10-03T21:16:53","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/fast-analysis-of-fluorotelomer-alcohols\/"},"modified":"2026-03-11T20:43:18","modified_gmt":"2026-03-11T20:43:18","slug":"fast-analysis-of-fluorotelomer-alcohols","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/it\/articles-zh\/evfa4311\/fast-analysis-of-fluorotelomer-alcohols","title":{"rendered":"Fast Analysis of Fluorotelomer Alcohols"},"content":{"rendered":"\n<p>\u2022 &nbsp; &nbsp;1.9x faster than conventional GC-MS analysis.<br>\u2022 &nbsp; &nbsp;Reduces helium usage by 60% compared to conventional GC-MS methods.&nbsp;<br>\u2022 &nbsp; &nbsp;LPGC kits are factory connected with a proven leak-free connector making LPGC as simple as a column change.<\/p>\n\n\n\n<p>Fluorotelomer alcohols (FTOHs) have recently emerged as an important class of PFAS compounds in environmental testing laboratories. These compounds are commonly used in manufacturing materials for their oil and water-repellant capabilities but have recently been found to degrade into toxic compounds that pose health and environmental concerns. The degradation products of these volatile FTOHs are frequently detected in indoor and outdoor air samples and thus are important to monitor. Since FTOHs are an emerging class of compounds, testing methodologies are limited. In this application, we developed a rapid analysis of four common fluorotelomer alcohols on the LPGC Rtx-200, achieving excellent separations with a run time of under four minutes. As show in Figure 1, the optimized LPGC method is 1.9x faster and uses 60% less helium than conventional methods. Despite significant speeds gains, excellent separations were still achieved for all isobars.<\/p>\n\n\n\n<p>Utilizing LPGC for analysis of FTOHs significantly reduces analysis time, improving lab productivity while also conserving helium. Each of our factory-coupled LPGC kits are individually tested, so you can have the assurance of a leak-free connection. To learn more about this powerful technique, visit www.restek.com\/lpgc<\/p>\n\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\"><strong>Figure 1:\u00a0<\/strong>Comparison of Conventional and LPGC-MS Analysis of Fluorotelomer Alcohols<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<div class=\"wp-block-custom-chromatogram-article\"><div class=\"wp-block-custom-chromatogram-article\"><div class=\"chromatogram-image wide-image\"><img decoding=\"async\" src=\"https:\/\/ez.restek.com\/images\/cgram\/gc_ev1519.png\" alt=\"Comparison of Conventional and LPGC-MS Analysis of Fluorotelomer Alcohols\" title=\"-\"><\/div><p class=\"article-id\" style=\"text-align:center\"> GC_EV1519<\/p><div class=\"chromatogram-peaks\"><h4>Peaks<\/h4><table class=\"peaks col-lg-6 col-12\">\n<thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">Conc.<br \/>(\u00b5g\/g)<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> (30 m)<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> (LPGC)<\/th><\/tr><\/thead>\n<tbody><tr><td class=\"num\">1.<\/td><td class=\"cmpd\">4:2 FTOH (2-perfluorobutyl alcohol)<\/td><td class=\"oth\">2<\/td><td class=\"oth\">3.10<\/td><td class=\"oth\">1.90<\/td><\/tr>\n<tr><td class=\"num\">2.<\/td><td class=\"cmpd\">6:2 FTOH (2-perfluorohexyl alcohol)<\/td><td class=\"oth\">2<\/td><td class=\"oth\">4.17<\/td><td class=\"oth\">2.43<\/td><\/tr>\n<tr><td class=\"num\">3.<\/td><td class=\"cmpd\">8:2 FTOH (2-perfluorooctyl alcohol)<\/td><td class=\"oth\">2<\/td><td class=\"oth\">5.44<\/td><td class=\"oth\">3.01<\/td><\/tr>\n<tr><td class=\"num\">4.<\/td><td class=\"cmpd\">10:2 FTOH (2-perfluorodecyl alcohol)<\/td><td class=\"oth\">2<\/td><td class=\"oth\">6.65<\/td><td class=\"oth\">3.53<\/td><\/tr>\n<\/tbody><\/table><\/div><div class=\"chromatogram-conditions\"><h4>Conditions<\/h4><div class=\"conditions-container container-fluid\"><div class=\"row\"><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Column<\/th><td>See notes<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Standard\/Sample<\/th><td><\/td><\/tr><tr><td><\/td><td>2-(Perfluorobutyl)ethanol<\/td><\/tr><tr><td><\/td><td>2-(Perfluorohexyl)ethanol<\/td><\/tr><tr><td><\/td><td>2-(Perfluorooctyl)ethanol<\/td><\/tr><tr><td><\/td><td>2-(Perfluorodecyl)ethanol<\/td><\/tr>\n<tr><th class=\"sub conditions_header\" scope=\"row\">Diluent:<\/th><td>Methanol<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Conc.:<\/th><td>2 \u00b5g\/mL<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Injection<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Vol.:<\/th><td>1 \u00b5L split (split ratio 5:1)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Liner:<\/th><td>Topaz, precision inlet liner, 4.0 mm x 6.3 x 78.5 (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/23305?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_EV1519\" rel=\"noopener\">cat.# 23305<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Temp.:<\/th><td>280 \u00b0C<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Carrier Gas<\/th><td>He<\/td><\/tr><\/table><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Detector<\/th><td>MS<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Mode:<\/th><td>SIM<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">SIM Program:<\/th><td colspan=\"2\">131 m\/z, 300 ms dwell<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Transfer Line Temp.:<\/th><td>280 \u00b0C<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Analyzer Type:<\/th><td>Quadrupole <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Source Temp.:<\/th><td>250 \u00b0C<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Quad Temp.:<\/th><td>180 \u00b0C<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Tune Type:<\/th><td>PFTBA <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ionization Mode:<\/th><td>EI <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Instrument<\/th><td>Agilent 7890B GC &amp; 5977A MSD<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Sample Preparation<\/th><td>All standards (original concentration of 100 \u00b5g\/mL) were combined into one solution at a concentration 1 ppm in polypropylene vial (cat. #23242) with a polypropylene cap (cat. #23244). A 50 \u00b5L aliquot was analyzed by GC-MS using a 100 \u00b5L insert (cat. #24512).<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Notes<\/th><td><b>Conventional (30 m) Analysis:<\/b><br \/>Column: Rtx-200ms, 30 m, 0.25 mm ID, 0.25 \u00b5m (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/15623?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_EV1519\" rel=\"noopener\">cat.# 15623<\/a>)<br \/>Temp. program: 35 \u00b0C (hold 1 min) to 280 \u00b0C at 15 \u00b0C\/min (hold 5 min)<br \/>Flow: 1.2 mL\/min<br \/>SIM start: 2.5 min<br \/>SIM: 131 m\/z, 300 ms<br \/><br \/><b>LPGC-MS Analysis:<\/b><br \/>Column: LPGC Rtx-200 column kit, includes 10 m x 0.32 mm ID x 1.00 \u00b5m Rtx-200 analytical column and 5 m x 0.15 mm ID Rxi restrictor factory connected via SilTite connector (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/11807?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_EV1519\" rel=\"noopener\">cat.# 11807<\/a>)<br \/>Temp. program: 35 \u00b0C (hold 0.5 min) to 280 \u00b0C at 35 \u00b0C\/min (hold 5 min)<br \/>Flow: 0.9 mL\/min<br \/>SIM start: 1.5 min<br \/>SIM: 131 m\/z, 300 ms<br \/><br \/>Pulsed split injection was used; 30 psi until 0.15 min.<br \/><br \/>The injections were performed on different instruments under different head pressures, resulting in different analyte responses.<\/td><\/tr><\/table><\/div><\/div><\/div><div class=\"chromatogram-pdf-link\"><a href=\"https:\/\/ez.restek.com\/images\/cgram\/gc_ev1519.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"18\" height=\"18\" viewBox=\"0 0 18 18\"><g data-name=\"Group 2996\"><path data-name=\"Rectangle 1246\" d=\"M0 0h18v18H0z\" style=\"fill: none;\"><\/path><\/g><g data-name=\"Group 2997\"><path data-name=\"Path 729\" d=\"M13.412 11.4v2.017H5.345V11.4H4v2.017a1.349 1.349 0 0 0 1.345 1.345h8.068a1.349 1.349 0 0 0 1.345-1.345V11.4zm-.672-2.694-.948-.948-1.741 1.735V4H8.706v5.493L6.965 7.758l-.948.948 3.361 3.361z\" transform=\"translate(-.437 -.414)\" style=\"fill: rgb(13, 123, 196);\"><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n        <div class=\"cpb\">\n            <h3 class=\"cpb-heading\">Products Mentioned<\/h3>\n            <hr class=\"cpb-heading-underline\" \/>\n            <div class=\"cpb-list\">\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/11807\">                                Catalog No. 11807                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Kit colonna LPGC Rtx-200<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/11807\">Esplora Prodotto<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/23305\">                                Catalog No. 23305                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Topaz Inlet Liner Precision, 4,0 mm x 6,3 x 78,5, per GC Agilent, con Lana di Quarzo, Deattivazione Premium, 5 pz.<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/23305\">Esplora Prodotto<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/23849\">                                Catalog No. 23849                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Kit inserti per forno GC Accelerator, per GC Agilent 5890, 6890, 7890 e 8890<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/23849\">Esplora Prodotto<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/23244\">                                Catalog No. 23244                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Tappi in polietilene da 2,0 mL con top solido di 9 mm, filettatura, membrana spessore 10 mm, trasparente, 100 pz.<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/23244\">Esplora Prodotto<\/a>\n                                                    <\/div>\n                    <\/div>\n                            <\/div>\n        <\/div>\n        \n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>This rapid analysis of fluorotelomer alcohol by low-pressure GC-MS is 1.9x faster than conventional GC-MS analysis and offers up to 60% helium savings.<\/p>\n","protected":false},"author":11,"featured_media":6733,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[786],"tags":[],"industries-application":[2186,2185],"post-badge":[],"resource-type":[2623],"product-library":[2408,2420,2422],"resource-technique":[2307,2311,2312],"ppma_author":[414],"class_list":["post-43501","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles-zh","industries-application-air-monitoring-zh","industries-application-environmental-zh","resource-type-featured-application","product-library-gas-chromatography-products-zh","product-library-gc-columns-zh","product-library-inlet-supplies-zh","resource-technique-gas-chromatography-gc-zh","resource-technique-low-pressure-gc-lpgc-zh","resource-technique-mass-spectrometry-ms-zh"],"acf":[],"taxonomy_info":{"category":[{"value":786,"label":"\u6587\u7ae0"}],"industries-application":[{"value":2186,"label":"\u7a7a\u6c14\u76d1\u6d4b"},{"value":2185,"label":"\u73af\u5883"}],"resource-type":[{"value":2623,"label":"Featured 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