{"id":51637,"date":"2021-08-17T14:30:00","date_gmt":"2021-08-17T14:30:00","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/how-do-our-gc-chiral-columns-compare\/"},"modified":"2025-10-23T23:21:07","modified_gmt":"2025-10-23T23:21:07","slug":"how-do-our-gc-chiral-columns-compare","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/it\/blogs-zh\/gnbl4618\/how-do-our-gc-chiral-columns-compare","title":{"rendered":"Chiral Separations 1: How do our GC chiral columns compare?"},"content":{"rendered":"\n

Predicting chiral separations is challenging. Using standard capillary columns, general predictions about separations can be made based on the solubility of compounds in different phases; however, chiral predictions are far more complicated.

To make this decision somewhat easier, we compiled resolution values for the enantiomers of 21 chiral compounds with different functional groups, such as terpenes, alcohols or lactones.<\/p>\n\n\n\n

 <\/td>Column Resolution Factors<\/strong><\/td><\/tr>
 Compounds<\/strong><\/td>Rt-\u03b2DEX sm<\/strong><\/td>Rt-\u03b2DEX se<\/strong><\/td>Rt-\u03b2DEX sp<\/strong><\/td>Rt-\u03b2DEX sa<\/strong><\/td>Rt-\u03b2DEX cst<\/strong><\/td>Rt-\u03b2DEX m<\/strong><\/td><\/tr>
Terpenes<\/em><\/td>1<\/td>\u03b1-pinene<\/td>3.14<\/td>0.82<\/td>ns<\/em><\/td>ns<\/em><\/td>0.82<\/td>3.19<\/td><\/tr>
 <\/td>2<\/td>limonene<\/td>5.60<\/td>8.05<\/td>1.22<\/td>ns<\/em><\/td>2.04<\/td>1.41<\/td><\/tr>
Alcohols<\/em><\/td>3<\/td>1-octen-3-ol<\/td>1.08<\/td>ns<\/em><\/td>ns<\/em><\/td>2.00<\/td>ns<\/em><\/td>ns<\/em><\/td><\/tr>
 <\/td>4<\/td>linalool<\/td>3.10<\/td>5.96<\/td>1.79<\/td>1.60<\/td>2.25<\/td>1.01<\/td><\/tr>
 <\/td>5<\/td>\u03b1-terpineol<\/td>4.72<\/td>5.20<\/td>1.29<\/td>2.82<\/td>2.69<\/td>1.54<\/td><\/tr>
 <\/td>6<\/td>terpinen-4-ol<\/td>1.90<\/td>1.92<\/td>ns<\/em><\/td>2.47<\/td>ns<\/em><\/td>1.41<\/td><\/tr>
 <\/td>7<\/td>isoborneol<\/td>3.76<\/td>3.35<\/td>ns<\/em><\/td>0.79<\/td>1.87t<\/td>2.15<\/td><\/tr>
 <\/td>8<\/td>\u03b2-citronellol<\/td>0.80<\/td>0.89<\/td>ns<\/em><\/td>0.98<\/td>ns<\/em><\/td>ns<\/em><\/td><\/tr>
 <\/td>9<\/td>menthol<\/td>1.24<\/td>1.24<\/td>1.07<\/td>0.93<\/td>0.89<\/td>1.58<\/td><\/tr>
 <\/td>10<\/td>2,3-butanediol<\/td>6.44<\/td>7.10<\/td>1.46<\/td>2.61<\/td>1.27<\/td>2.43<\/td><\/tr>
 <\/td>11<\/td>1-phenylethanol<\/td>7.52<\/td>6.52<\/td>ns<\/em><\/td>6.43<\/td>4.87<\/td>5.88<\/td><\/tr>
Ketones<\/em><\/td>12<\/td>camphor<\/td>1.70<\/td>2.13<\/td>0.50<\/td>4.20<\/td>2.22t<\/td>ns<\/em><\/td><\/tr>
 <\/td>13<\/td>\u03b1-ionone<\/td>5.67<\/td>3.31<\/td>0.80<\/td>4.69<\/td>1.37<\/td>2.81<\/td><\/tr>
<\/td>14<\/td>menthone<\/td>0.59<\/td>5.76<\/td>ns<\/em><\/td>1.16<\/td>2.60<\/td>4.11<\/td><\/tr>
Lactones<\/em><\/td>15<\/td>\u03b3-nonalactone<\/td>4.19<\/td>5.07<\/td>2.11<\/td>4.00<\/td>3.82<\/td>1.03<\/td><\/tr>
<\/td>16<\/td>\u03b3-undecalactone<\/td>2.39<\/td>3.24<\/td>1.20<\/td>3.65<\/td>3.18<\/td>ns<\/em><\/td><\/tr>
 <\/td>17<\/td>\u03b4-dodecalactone<\/td>0.80<\/td>ns<\/em><\/td>ns<\/em><\/td>1.91<\/td>1.69<\/td>ns<\/em><\/td><\/tr>
 <\/td>18<\/td>ethyl-2-methylbutyrate<\/td>3.94<\/td>4.66<\/td>ns<\/em><\/td>ns<\/em><\/td>ns<\/em><\/td>0.92<\/td><\/tr>
Esters<\/em><\/td>19<\/td>linalyl acetate<\/td>ns<\/em><\/td>2.36<\/td>ns<\/em><\/td>ns<\/em><\/td>ns<\/em><\/td>ns<\/em><\/td><\/tr>
 <\/td>20<\/td>styrene oxide<\/td>4.53<\/td>10.77<\/td>2.86<\/td>2.26<\/td>1.16t<\/td>3.03<\/td><\/tr>
Epoxides<\/em><\/td>21<\/td>trans<\/em>-linalool oxide<\/td>9.71<\/td>2.96<\/td>ns<\/em><\/td>1.20<\/td>3.02t<\/td>7.44<\/td><\/tr>
 <\/td>21<\/td>cis<\/em>-linalool oxide<\/td>6.06<\/td>4.28<\/td>ns<\/em><\/td>0.91<\/td>2.19t<\/td>4.38<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
<\/div>\n","protected":false},"excerpt":{"rendered":"

Predicting chiral separations is challenging. To make this decision somewhat easier, we compiled resolution values from 21 chiral compounds with different functional groups, such as terpenes, alcohols or lactones.<\/p>\n","protected":false},"author":50,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[790],"tags":[],"industries-application":[2149,2167],"post-badge":[],"resource-type":[],"product-library":[],"resource-technique":[2294],"ppma_author":[591],"class_list":["post-51637","post","type-post","status-publish","format-standard","hentry","category-blogs-zh","industries-application-cannabis","industries-application-food-beverage","resource-technique-gas-chromatography-gc"],"acf":[],"taxonomy_info":{"category":[{"value":790,"label":"\u535a\u5ba2"}],"industries-application":[{"value":2149,"label":"Cannabis"},{"value":2167,"label":"Food & Beverage"}],"resource-technique":[{"value":2294,"label":"Gas Chromatography (GC)"}]},"featured_image_src_large":false,"author_info":{"display_name":"Jana Hepner, PhD","author_link":"https:\/\/discover.restek.com\/it\/author\/jana-hepner-phd\/"},"comment_info":0,"category_info":[{"term_id":790,"name":"\u535a\u5ba2","slug":"blogs-zh","term_group":0,"term_taxonomy_id":790,"taxonomy":"category","description":"","parent":0,"count":438,"filter":"raw","cat_ID":790,"category_count":438,"category_description":"","cat_name":"\u535a\u5ba2","category_nicename":"blogs-zh","category_parent":0}],"tag_info":false,"authors":[{"term_id":591,"user_id":50,"is_guest":0,"slug":"jana-hepner-phd","display_name":"Jana Hepner, PhD","avatar_url":{"url":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-hepner-jana.jpg","url2x":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-hepner-jana.jpg"},"0":null,"1":"","2":"","3":"","4":"","5":"","6":"","7":"","8":""}],"_links":{"self":[{"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/posts\/51637","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/users\/50"}],"replies":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/comments?post=51637"}],"version-history":[{"count":3,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/posts\/51637\/revisions"}],"predecessor-version":[{"id":56838,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/posts\/51637\/revisions\/56838"}],"wp:attachment":[{"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/media?parent=51637"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/categories?post=51637"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/tags?post=51637"},{"taxonomy":"industries-application","embeddable":true,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/industries-application?post=51637"},{"taxonomy":"post-badge","embeddable":true,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/post-badge?post=51637"},{"taxonomy":"resource-type","embeddable":true,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/resource-type?post=51637"},{"taxonomy":"product-library","embeddable":true,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/product-library?post=51637"},{"taxonomy":"resource-technique","embeddable":true,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/resource-technique?post=51637"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/discover.restek.com\/it\/wp-json\/wp\/v2\/ppma_author?post=51637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}