LC-MS/MS analysis of EtG and EtS is challenging due primarily to poor retention and resolution of EtG and EtS from matrix components. This article presents a foundation method that is useful for many samples and also demonstrates effective strategies for improving sensitivity and mitigating matrix effects.
As the demand for testing of pain management drugs increases, many laboratories are turning to LC-MS/MS for its increased speed, sensitivity, and specificity. The methods shown here use a Raptor Biphenyl column because it provides fast, accurate analysis of 231 drugs and drug metabolites.
A new LC-MS/MS method for methylmalonic acid (MMA) analysis was developed that provides complete chromatographic resolution from isobaric succinic acid in plasma samples. Excellent chromatographic results were obtained from the direct injection of a protein crash sample supernatant onto a Force C18 column, providing a much simpler sample preparation compared to typical methods.
Sometimes customers need to analyze natural gas and petroleum products, whether it is to confirm the purity of the product by looking for the impurities which may be present, or for an environmental reason such as a spill or leak….
If you use the correct fittings and seals in the gas chromatography system, and follow some simple steps, there is absolutely no need to over tighten any fitting to achieve a leak free seal. For almost all fittings that use…
年末が近づいてくると、ノスタルジックな気分に少しなり、多くの専門家が過去を回顧することを良しとします1。そして私たちはちょっと楽観的で寛大にもなります。研究者たちはまた、寒い部屋の方が暖かな場所にいるよりも懐かしさが増すことに気づきました…
LC-MS/MS using electrospray ionization (ESI) is a widely used platform for routine target analysis and quantitation. However, one big challenge faced through the use of ESI is the presence of matrix effects. So, what are matrix effects and why are…
If excessive force is applied at an angle to a fitting or column connector, the ferrule could become stuck in the column end fitting. Likewise, a PEEK connector, column nut or plug can also break and leave part of it…
My colleague, Joe Konschnik and I have been asked by many food chemists out there about how much they can trust their pesticides mixes after they combine them into one single larger mixture for calibrating their instrument, or monitoring the…
PFASの最新分析動向とRestek Raptor C18カラムを用いた高速・高精度分析を解説。GenXやPFBSなどの代替フッ素化合物の測定に対応し、多様な成分分析や良好な分離を求める環境ラボに最適なカラムソリューションを提案します。
