{"id":43359,"date":"2024-02-01T00:00:00","date_gmt":"2024-02-01T00:00:00","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/fast-analysis-of-%ce%b48-thc-%ce%b49-thc-and-isomeric-hydroxy-and-carboxy-metabolites-in-whole-blood-by-lc-ms-ms-japan\/"},"modified":"2026-01-14T17:02:56","modified_gmt":"2026-01-14T17:02:56","slug":"fast-analysis-of-d8-thc-d9-thc-and-isomeric-hydroxy-and-carboxy-metabolites-in-whole-blood-by-lc-ms-ms-japan","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/ja\/application-notes-ja\/cfan4213-ja\/fast-analysis-of-d8-thc-d9-thc-and-isomeric-hydroxy-and-carboxy-metabolites-in-whole-blood-by-lc-ms-ms-japan","title":{"rendered":"\u5168\u8840\u4e2d\u03948-THC\u30fb\u03949-THC\u7570\u6027\u4f53\u306e\u9ad8\u7cbe\u5ea6LC-MS\/MS\u30e1\u30bd\u30c3\u30c9\u306b\u3088\u308b\u5206\u6790\u65b9\u6cd5"},"content":{"rendered":"\n

\u306f\u3058\u3081\u306b<\/h2>\n\n\n\n

\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u30ab\u30f3\u30ca\u30d3\u30ce\u30fc\u30eb\uff08\u03949-THC\uff09\u6442\u53d6\u3092\u8abf\u3079\u308b\u5168\u8840\u30b5\u30f3\u30d7\u30eb\u691c\u67fb\u306f\u3001\u9577\u5e74\u306b\u308f\u305f\u308a\u81e8\u5e8a\u73fe\u5834\u3067\u6a19\u6e96\u7684\u306b\u5b9f\u65bd\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u03949-THC\u306f\u4f53\u5185\u306711-\u30d2\u30c9\u30ed\u30ad\u30b7-\u03949-THC\uff0811-OH-\u03949-THC\uff09\u306b\u4ee3\u8b1d\u3055\u308c\u3001\u3055\u3089\u306b11-\u30ce\u30eb-9-\u30ab\u30eb\u30dc\u30ad\u30b7-\u03949-THC\uff08\u03949-THC-COOH\uff09\u3078\u3068\u5909\u63db\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001THC\u306e\u6442\u53d6\u72b6\u6cc1\u3092\u6b63\u78ba\u306b\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3059\u308b\u306b\u306f\u3001\u89aa\u5316\u5408\u7269\u30682\u7a2e\u985e\u306e\u4e3b\u8981\u4ee3\u8b1d\u7269\u3092\u540c\u6642\u306b\u5206\u6790\u3059\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n\n\n\n

\u5e02\u5834\u306b\u6d41\u901a\u3059\u308b\u03949-THC\u7570\u6027\u4f53\u306e\u5897\u52a0\u306b\u4f34\u3044\u3001\u691c\u67fb\u3082\u8907\u96d1\u5316\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u7570\u6027\u4f53\u3092\u78ba\u5b9f\u306b\u5206\u96e2\u3059\u308b\u65b0\u305f\u306a\u30e1\u30bd\u30c3\u30c9\u958b\u767a\u3078\u306e\u8fc5\u901f\u306a\u5bfe\u5fdc\u304c\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u03949-THC\u7570\u6027\u4f53\u306e\u4e2d\u3067\u3082\u3001\u7279\u306b\u03948-THC\u306f\u7c73\u56fd\u9023\u90a6\u6cd5\u3067\u898f\u5236\u3055\u308c\u3066\u3044\u306a\u3044\u305f\u3081\u3001\u5e02\u5834\u306b\u304a\u3051\u308b\u6d41\u901a\u91cf\u5897\u52a0\u304c\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u03948-THC\u3082\u03949-THC\u3068\u540c\u69d8\u306b\u30d2\u30c9\u30ed\u30ad\u30b7\u4ee3\u8b1d\u7269\uff0811-OH-\u03948-THC\uff09\u304a\u3088\u3073\u30ab\u30eb\u30dc\u30ad\u30b7\u4ee3\u8b1d\u7269\uff08\u03948-THC-COOH\uff09\u306b\u5909\u63db\u3055\u308c\u308b\u306e\u3067\u3001\u3053\u308c\u3089\u306e\u7570\u6027\u4f53\u304a\u3088\u3073\u305d\u306e\u4ee3\u8b1d\u7269\u3092\u660e\u78ba\u306b\u5206\u96e2\u3057\u3066\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u306b\u306a\u3063\u3066\u304d\u307e\u3059\u3002\u7570\u6027\u4f53\u30da\u30a2\u306e\u5206\u96e2\u304c\u4e0d\u5341\u5206\u306a\u5834\u5408\u3001\u7279\u306b\u4e00\u65b9\u306e\u7570\u6027\u4f53\u304c\u9ad8\u6fc3\u5ea6\u3067\u5b58\u5728\u3059\u308b\u30b1\u30fc\u30b9\u3067\u306f\u3001\u81e8\u5e8a\u5831\u544a\u306e\u7cbe\u5ea6\u304c\u5927\u304d\u304f\u640d\u306a\u308f\u308c\u308b\u30ea\u30b9\u30af\u304c\u3042\u308a\u3001\u3053\u308c\u3092\u9632\u3050\u305f\u3081\u306b\u3082\u5206\u6790\u30e1\u30bd\u30c3\u30c9\u306e\u66f4\u306a\u308b\u9032\u5c55\u304c\u5f37\u304f\u6c42\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u672c\u7814\u7a76\u3067\u306f\u3001\u5168\u8840\u4e2d\u306b\u5b58\u5728\u3059\u308b6\u7a2e\u985e\u3059\u3079\u3066\u306e\u7570\u6027\u4f53\u3092\u5341\u5206\u306b\u5206\u96e2\u53ef\u80fd\u306a\u65b0\u898fLC-MS\/MS\u30e1\u30bd\u30c3\u30c9\u3092\u958b\u767a\u3057\u3001\u305d\u306e\u76f4\u7dda\u6027\u3001\u7cbe\u5ea6\u3001\u518d\u73fe\u6027\u3001\u306a\u3089\u3073\u306b\u4ed6\u6210\u5206\u304b\u3089\u306e\u5e72\u6e09\u306e\u6709\u7121\u3092\u7dcf\u5408\u7684\u306b\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u5b9f\u9a13<\/h2>\n\n\n\n

\u6db2\u6db2\u62bd\u51fa [1]<\/em><\/h3>\n\n\n\n
    \n
  1. \u30d6\u30e9\u30f3\u30af\u306e\u5168\u8840\u30b5\u30f3\u30d7\u30eb500 \u03bcL\u3092\u30ac\u30e9\u30b9\u88fd\u8a66\u9a13\u7ba1\u306b\u52a0\u3048\u308b<\/li>\n\n\n\n
  2. \u6821\u6b63\u7528\u6a19\u6e96\u6eb6\u6db250 \u03bcL\u304a\u3088\u3073QC\u7528\u6a19\u6e96\u6eb6\u6db250 \u03bcL\u3092\u5404\u8a66\u9a13\u7ba1\u306b\u52a0\u3048\u305f\u5f8c\u3001\u5185\u90e8\u6a19\u6e96\u7269\u8cea\uff08\u03949-THC-D3\u300111-OH-\u03949-THC-D3\u3001\u03949-THC-COOH-D3 \u6fc3\u5ea6:1000 ng\/mL\uff0950 \u03bcL\u3092\u5404\u30b5\u30f3\u30d7\u30eb\u306b\u6dfb\u52a0\u3057\u3001\u30dc\u30eb\u30c6\u30c3\u30af\u30b9<\/li>\n\n\n\n
  3. HPLC\u30b0\u30ec\u30fc\u30c9\u6c34500 \u03bcL\u3092\u5404\u8a66\u9a13\u7ba1\u306b\u6dfb\u52a0\u3057\u3001\u30dc\u30eb\u30c6\u30c3\u30af\u30b9<\/li>\n\n\n\n
  4. 1N\u5869\u9178100 \u03bcL\u3092\u5404\u8a66\u9a13\u7ba1\u306b\u6dfb\u52a0\u3057\u3001\u30dc\u30eb\u30c6\u30c3\u30af\u30b9<\/li>\n\n\n\n
  5. \u30d8\u30ad\u30b5\u30f3:\u9162\u9178\u30a8\u30c1\u30eb\u309280:20\u3067\u8abf\u88fd\u3057\u305f\u6eb6\u6db22.5 mL\u3092\u5404\u8a66\u9a13\u7ba1\u306b\u6dfb\u52a0\u3057\u3001\u30ad\u30e3\u30c3\u30d7\u3092\u3057\u305f\u5f8c\u3001\u76ee\u8996\u3067\u6df7\u5408\u304c\u78ba\u8a8d\u3067\u304d\u308b\u307e\u3067\u30dc\u30eb\u30c6\u30c3\u30af\u30b9<\/li>\n\n\n\n
  6. 4200 rpm\u306715\u5206\u9593\u3001\u307e\u305f\u306f2\u3064\u306e\u5c64\u304c\u5b8c\u5168\u306b\u5206\u96e2\u3059\u308b\u307e\u3067\u9060\u5fc3\u5206\u96e2<\/li>\n\n\n\n
  7. \u5404\u30b5\u30f3\u30d7\u30eb\u304b\u3089\u306e\u4e0a\u6e05\u3092\u65b0\u3057\u3044\u8a66\u9a13\u7ba1\u306b\u79fb\u3057\u3001\u7a92\u7d20\u4e0b\u3067\u4e7e\u56fa<\/li>\n\n\n\n
  8. 0.1%\u30ae\u9178\u3092\u542b\u3080\u6c34:\u30e1\u30bf\u30ce\u30fc\u30eb\u309250:50\u3067\u8abf\u88fd\u3057\u305f\u6eb6\u6db2100 \u03bcL\u3067\u518d\u6eb6\u89e3\u3057\u30dc\u30eb\u30c6\u30c3\u30af\u30b9\u3001\u30a4\u30f3\u30b5\u30fc\u30c8\u4ed8\u304d\u306eLC\u30d0\u30a4\u30a2\u30eb\u306b\u79fb\u3057\u305f\u30b5\u30f3\u30d7\u30eb\u3092\u5206\u6790<\/li>\n<\/ol>\n\n\n\n

    \u88c5\u7f6e\u30d1\u30e9\u30e1\u30fc\u30bf<\/em><\/h3>\n\n\n\n

    \u03948-THC\u3001\u03949-THC\u300111-OH-\u03948-THC\u300111-OH-\u03949-THC\u3001\u03948-THC-COOH\u3001\u304a\u3088\u3073\u03949-THC-COOH\u306e\u5206\u96e2\u3092\u6700\u9069\u5316\u3059\u308b\u305f\u3081\u306eLC-MS\/MS\u30e1\u30bd\u30c3\u30c9\u3092Raptor FluoroPhenyl\u30ab\u30e9\u30e0\u3067\u958b\u767a\u3057\u307e\u3057\u305f\uff08\u8a73\u7d30\u306fTable I<\/strong>\u304a\u3088\u3073Table II<\/strong>\u3092\u53c2\u7167\uff09\u3002\u5404\u5206\u6790\u5bfe\u8c61\u6210\u5206\u306eMRM\u30c8\u30e9\u30f3\u30b8\u30b7\u30e7\u30f3\u3068ESI\u30e2\u30fc\u30c9\u306fFigure 1<\/strong>\u3092\u3054\u53c2\u7167\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n

    Table I:<\/strong> \u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u30b0\u30e9\u30b8\u30a8\u30f3\u30c8<\/p>\n\n\n\n

    \u6642\u9593 (min)<\/strong><\/th>\u6d41\u901f (mL\/min)<\/strong><\/th>%A<\/strong><\/th>%B<\/strong><\/th><\/tr><\/thead>
    0.00<\/td>0.8<\/td>36<\/td>64<\/td><\/tr>
    6.50<\/td>0.8<\/td>36<\/td>64<\/td><\/tr>
    6.60<\/td>0.8<\/td>32<\/td>68<\/td><\/tr>
    13.00<\/td>0.8<\/td>32<\/td>68<\/td><\/tr>
    13.10<\/td>0.8<\/td>0<\/td>100<\/td><\/tr>
    14.00<\/td>0.8<\/td>0<\/td>100<\/td><\/tr>
    14.10<\/td>0.8<\/td>36<\/td>64<\/td><\/tr>
    16.00<\/td>0.8<\/td>36<\/td>64<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

    Table II: <\/strong>LC\u30e1\u30bd\u30c3\u30c9\u30d1\u30e9\u30e1\u30fc\u30bf<\/p>\n\n\n\n

    \u5206\u6790\u7528\u30ab\u30e9\u30e0<\/strong><\/td>Raptor FluoroPhenyl, 2.7 \u03bcm, 100 mm x 3.0 mm ID (cat.# 9319A1E)<\/td><\/tr>
    \u30ac\u30fc\u30c9\u30ab\u30e9\u30e0<\/strong><\/td>Raptor FluoroPhenyl EXP guard column cartridge 5 mm, 3.0 mm ID, 2.7 \u03bcm (cat.# 9319A0253)<\/td><\/tr>
    \u30ab\u30e9\u30e0\u6e29\u5ea6<\/strong><\/td>40 \u00b0C<\/td><\/tr>
    \u79fb\u52d5\u76f8A<\/strong><\/td>0.1% \u30ae\u9178\u6c34\u6eb6\u6db2<\/td><\/tr>
    \u79fb\u52d5\u76f8B<\/strong><\/td>0.1% \u30ae\u9178\u30e1\u30bf\u30ce\u30fc\u30eb\u6eb6\u6db2<\/td><\/tr>
    \u6ce8\u5165\u91cf<\/strong><\/td>10 \u00b5L<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

    \u7d50\u679c\u3068\u8003\u5bdf<\/h2>\n\n\n\n

    \u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u6027\u80fd<\/em><\/h3>\n\n\n\n

    Raptor FluoroPhenyl\u30ab\u30e9\u30e0\u3092\u7528\u3044\u305f13\u5206\u9593\u306e\u9ad8\u901f\u30b0\u30e9\u30b8\u30a8\u30f3\u30c8\uff08\u7dcf\u5206\u6790\u6642\u959316\u5206\uff09\u306b\u3088\u308a\u30013\u7d44\u306e\u7570\u6027\u4f53\uff08\u8a086\u6210\u5206\uff09\u304c\u3059\u3079\u3066\u826f\u597d\u306b\u5206\u96e2\u3055\u308c\u307e\u3057\u305f\u3002FluoroPhenyl\u56fa\u5b9a\u76f8\u306f\u3001\u5f93\u6765\u306e\u30d3\u30d5\u30a7\u30cb\u30eb\u3084C18\u30ab\u30e9\u30e0\u3068\u6bd4\u8f03\u3057\u3066\u3001\u7570\u6027\u4f53\u9593\u306e\u9078\u629e\u6027\u306b\u512a\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\uff08Figure 1<\/strong>\u3092\u53c2\u7167\u304f\u3060\u3055\u3044\uff09\u3002<\/p>\n\n\n

    Figure 1:<\/strong> \u5168\u8840\u4e2d\u306e\u03948\/9-THC\u3001\u30d2\u30c9\u30ed\u30ad\u30b7\u4ee3\u8b1d\u7269\u3001\u30ab\u30eb\u30dc\u30ad\u30b7\u4ee3\u8b1d\u7269\u306e\u5206\u96e2\uff08\u5206\u6790\u6761\u4ef6\u306fPDF\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u53ef\uff09<\/div>
    \n
    \"\u03949-THC;<\/div>

    LC_CF0807<\/p>

    <\/path><\/g><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n
    <\/div>\n\n\n\n

    \u76f4\u7dda\u6027\u30fb\u7cbe\u5ea6\u30fb\u518d\u73fe\u6027<\/em><\/h3>\n\n\n\n

    1\/x\u00b2\u91cd\u307f\u4ed8\u3051\u7dda\u5f62\u56de\u5e30\u3092\u7528\u3044\u3066\u76f4\u7dda\u6027\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u304c\u3001\u3059\u3079\u3066\u306e\u5206\u6790\u5bfe\u8c61\u6210\u5206\u304c\u30010.99\u4ee5\u4e0a\u306e\u8a31\u5bb9\u53ef\u80fd\u306aR\u00b2\u5024\u3092\u793a\u3057\u3001\u512a\u308c\u305f\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u300211-OH-\u03948-THC\u300111-OH-\u03949-THC\u3001\u03948-THC\u3001\u03949-THC\u306b\u3064\u3044\u3066\u306f\u6fc3\u5ea60.5\uff5e100 ng\/mL\u306b\u3001\u03948-THC-COOH\u304a\u3088\u3073\u03949-THC-COOH\u306b\u3064\u3044\u3066\u306f\u6fc3\u5ea62.5\uff5e500 ng\/mL\u306b\u6821\u6b63\u7bc4\u56f2\u3092\u8a2d\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

    \u5404\u30b5\u30f3\u30d7\u30eb\u3092Low QC\uff08\u4f4e\u6fc3\u5ea6QC\uff09\u3001Medium QC\uff08\u4e2d\u6fc3\u5ea6QC\uff09\u3001High QC\uff08\u9ad8\u6fc3\u5ea6QC\uff09\u3068\u306a\u308b\u3088\u3046\u306b\u3057\u3066\u30013\u65e5\u9593\u306b\u308f\u305f\u308a\u518d\u73fe\u6027\u3068\u7cbe\u5ea6\u306e\u8a55\u4fa1\u3092\u5b9f\u65bd\u3057\u307e\u3057\u305f\uff0811-OH-\u03948-THC\u300111-OH-\u03949-THC\u3001\u03948-THC\u3001\u03949-THC\u306b\u3064\u3044\u3066\u306f\u305d\u308c\u305e\u308c\u306e\u6fc3\u5ea6\u304c5\u300110\u300150 ng\/mL\u306b\u3001\u03948-THC-COOH\u304a\u3088\u3073\u03949-THC-COOH\u306b\u3064\u3044\u3066\u306f\u305d\u308c\u305e\u308c\u306e\u6fc3\u5ea6\u304c25\u300150\u3001250 ng\/mL\u306b\u306a\u308b\u3088\u3046\u306a\u6dfb\u52a0\u30b5\u30f3\u30d7\u30eb\u3092\u4f5c\u6210\uff09\u3002\u3059\u3079\u3066\u306e\u6fc3\u5ea6\u306b\u304a\u3044\u3066\u56de\u53ce\u7387\u304cQC\u30b5\u30f3\u30d7\u30eb\u516c\u79f0\u5024\u306e\u00b110%\u4ee5\u5185\u306b\u53ce\u307e\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3001\u672c\u30e1\u30bd\u30c3\u30c9\u306e\u7cbe\u5ea6\u304c\u5341\u5206\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u540c\u65e5\u5185\u304a\u3088\u3073\u5225\u65e5\u9593\u306e%RSD\u308220%\u4ee5\u4e0b\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u672c\u30e1\u30bd\u30c3\u30c9\u306e\u518d\u73fe\u6027\u3082\u8a31\u5bb9\u7bc4\u56f2\u5185\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

    \u5206\u6790\u5bfe\u8c61\u6210\u5206\u9593\u306e\u76f8\u4e92\u5e72\u6e09<\/em><\/h3>\n\n\n\n

    \u5929\u7136\u7531\u6765\u306e\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u304c\u30bf\u30fc\u30b2\u30c3\u30c8\u5316\u5408\u7269\u306b\u5e72\u6e09\u3057\u306a\u3044\u3053\u3068\u3092\u5b9f\u8a3c\u3059\u308b\u305f\u3081\u306b\u3001CBDV\u3001CBD\u3001CBG\u3001THCV\u3001exo-THC\u3001CBL\u3001CBN\u3001\u039410-THC\u3001CBC\u306a\u3069\u3001\u69cb\u9020\u304c\u985e\u4f3c\u3057\u305f\u3001\u307e\u305f\u306f\u4e00\u822c\u7684\u306a9\u7a2e\u985e\u306e\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u3092\u6dfb\u52a0\u3057\u305f\u5168\u8840\u30b5\u30f3\u30d7\u30eb\u3092\u7528\u3044\u3066\u691c\u8a3c\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001Raptor FluoroPhenyl\u30ab\u30e9\u30e0\u306b\u3088\u308a\u3001\u5168\u3066\u306e\u30bf\u30fc\u30b2\u30c3\u30c8\u5316\u5408\u7269\u304c\u3053\u308c\u30899\u7a2e\u985e\u306e\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u304b\u3089\u5b8c\u5168\u306b\u5206\u96e2\u3055\u308c\u3001\u5e72\u6e09\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001\u9ad8\u3044\u9078\u629e\u6027\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\uff08Figure 2<\/strong>\u3092\u53c2\u7167\u304f\u3060\u3055\u3044\uff09\u3002<\/p>\n\n\n

    Figure 2:<\/strong> 9\u7a2e\u985e\u306e\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u304b\u3089\u306e\u03948\/9-THC\u3001\u30d2\u30c9\u30ed\u30ad\u30b7\u3001\u30ab\u30eb\u30dc\u30ad\u30b7\u4ee3\u8b1d\u7269\u306e\u5206\u96e2\uff08\u5206\u6790\u6761\u4ef6\u306fPDF\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u53ef\uff09<\/div>
    \n
    \"\u03949-THC;<\/div>

    LC_CF0808<\/p>

    Peaks<\/h4>\n
    <\/th>Peaks<\/th>tR<\/sub> (min)<\/th>Conc.
    (ng\/mL)<\/th>    		Precursor<\/th>Product 1<\/th>Product 2<\/th>Mode<\/th><\/tr><\/thead>\n
    1.<\/td>CBDV<\/a><\/td>3.52<\/td>50<\/td>287.4<\/td>165.0<\/td>231.1<\/td>+<\/td><\/tr>\n
    2.<\/td>11-OH-\u03948-THC<\/a><\/td>5.09<\/td>50<\/td>331.4<\/td>313.0<\/td>193.2<\/td>+<\/td><\/tr>\n
    3.<\/td>11-OH-\u03949-THC<\/a><\/td>5.50<\/td>50<\/td>331.4<\/td>313.0<\/td>193.2<\/td>+<\/td><\/tr>\n
    4.<\/td>\u03948-THC-COOH<\/td>5.53<\/td>250<\/td>343.0<\/td>298.9<\/td>244.8<\/td>–<\/td><\/tr>\n
    5.<\/td>\u03949-THC-COOH<\/td>6.44<\/td>250<\/td>343.0<\/td>298.9<\/td>244.8<\/td>–<\/td><\/tr>\n
    6.<\/td>CBD<\/a><\/td>6.81<\/td>50<\/td>315.5<\/td>193.0<\/td>259.0<\/td>+<\/td><\/tr>\n
    7.<\/td>CBG<\/a><\/td>7.56<\/td>50<\/td>317.5<\/td>193.0<\/td>123.0<\/td>+<\/td><\/tr>\n
    8.<\/td>THCV<\/a><\/td>7.65<\/td>50<\/td>287.4<\/td>165.0<\/td>123.0<\/td>+<\/td><\/tr>\n
    9.<\/td>exo-THC<\/a><\/td>10.63<\/td>50<\/td>315.5<\/td>193.0<\/td>259.0<\/td>+<\/td><\/tr>\n
    10.<\/td>\u03948-THC<\/a><\/td>11.67<\/td>50<\/td>315.5<\/td>193.0<\/td>123.0<\/td>+<\/td><\/tr>\n
    11.<\/td>\u03949-THC<\/a><\/td>12.17<\/td>50<\/td>315.5<\/td>193.0<\/td>123.0<\/td>+<\/td><\/tr>\n
    12.<\/td>CBL<\/a><\/td>12.43<\/td>50<\/td>315.5<\/td>235.2<\/td>193.0<\/td>+<\/td><\/tr>\n
    13.<\/td>\u039410-THC<\/td>13.88<\/td>50<\/td>315.5<\/td>193.1<\/td>259.0<\/td>+<\/td><\/tr>\n
    14.<\/td>CBN<\/a><\/td>13.93<\/td>50<\/td>311.4<\/td>223.0<\/td>293.1<\/td>+<\/td><\/tr>\n
    15.<\/td>CBC<\/a><\/td>13.93<\/td>50<\/td>315.5<\/td>193.1<\/td>259.0<\/td>+<\/td><\/tr>\n<\/tbody><\/table><\/div>
    <\/path><\/g><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n
    <\/div>\n\n\n\n

    \u7d50\u8ad6<\/h2>\n\n\n\n

    \u672c\u7814\u7a76\u3067\u78ba\u7acb\u3057\u305fRaptor FluoroPhenyl\u30ab\u30e9\u30e0\u3092\u7528\u3044\u308b\u9ad8\u901fLC-MS\/MS\u30e1\u30bd\u30c3\u30c9\u306b\u3088\u308a\u3001\u5168\u8840\u4e2d\u306e\u03948-THC\u304a\u3088\u3073\u03949-THC\u7570\u6027\u4f53\u306a\u3089\u3073\u306b\u305d\u306e\u30d2\u30c9\u30ed\u30ad\u30b7\uff0f\u30ab\u30eb\u30dc\u30ad\u30b7\u4ee3\u8b1d\u7269\u3092\u52b9\u7387\u7684\u304b\u3064\u9ad8\u7cbe\u5ea6\u306b\u5206\u96e2\u5206\u6790\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u4ed6\u306e\u30ab\u30f3\u30ca\u30d3\u30ce\u30a4\u30c9\u306b\u3088\u308b\u5e72\u6e09\u3082\u8a8d\u3081\u3089\u308c\u305a\u3001\u672c\u6cd5\u306f\u81e8\u5e8a\u691c\u67fb\u306b\u304a\u3044\u3066\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u7d50\u679c\u5831\u544a\u3092\u53ef\u80fd\u306b\u3059\u308b\u624b\u6cd5\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n

    \u53c2\u7167\u6587\u732e<\/h2>\n\n\n\n

    N.B. Tiscione, R . Miller, X . Shan, J . Sprague, D.T. Yeatman, An efficient, robust method for the determination of cannabinoids in whole blood by LC-MS-MS, J. Ana.l Toxicol. 40(8) (2016) 639-648. https:\/\/doi.org\/10.1093\/jat\/bkw063<\/a><\/p>\n\n\n\n

    <\/div>\n\n\n
    \n

    Products Mentioned<\/h3>\n
    \n
    \n
    \n
    \n Catalog No. 9319A1E <\/a> <\/div>\n
    \n
    Raptor FluoroPhenyl, 2.7 \u00b5m, 100 x 3.0 mm HPLC\u30ab\u30e9\u30e0<\/div>\n <\/div>\n
    \n \u88fd\u54c1\u60c5\u5831\u3092\u898b\u308b<\/a>\n <\/div>\n <\/div>\n
    \n
    \n Catalog No. 9319A0253 <\/a> <\/div>\n
    \n
    Raptor FluoroPhenyl EXP Guard Column Cartridge, 2.7 \u00b5m, 5 x 3.0 mm, 3-pk.<\/div>\n <\/div>\n
    \n \u88fd\u54c1\u60c5\u5831\u3092\u898b\u308b<\/a>\n <\/div>\n <\/div>\n
    \n
    \n Catalog No. 34090 <\/a> <\/div>\n
    \n
    delta 8-Tetrahydrocannabinol (Delta 8-THC) Standard, 1000 \u00b5g\/mL in P&T Methanol, 1 mL\/ampul<\/div>\n <\/div>\n
    \n \u88fd\u54c1\u60c5\u5831\u3092\u898b\u308b<\/a>\n <\/div>\n <\/div>\n
    \n
    \n Catalog No. 34067 <\/a> <\/div>\n
    \n
    delta 9-Tetrahydrocannabinol (Delta 9-THC) Standard, 1000 \u00b5g\/mL, P&T Methanol, 1 mL\/ampul<\/div>\n <\/div>\n
    \n \u88fd\u54c1\u60c5\u5831\u3092\u898b\u308b<\/a>\n <\/div>\n <\/div>\n
    \n
    \n Catalog No. 34068 <\/a> <\/div>\n
    \n
    (\u00b1)11-nor-9-carboxy-Delta-9-THC Standard, 100 \u00b5g\/mL, methanol, 1 mL\/ampul<\/div>\n <\/div>\n
    \n \u88fd\u54c1\u60c5\u5831\u3092\u898b\u308b<\/a>\n <\/div>\n <\/div>\n
    \n
    \n Catalog No. 21143 <\/a> <\/div>\n
    \n
    Short-Cap Vial with Grad Marking Spot, 9-425 Screw-Thread, 2.0 mL, 9 mm, 12 x 32 (vial only), Amber, 1000-pk.<\/div>\n <\/div>\n
    \n \u88fd\u54c1\u60c5\u5831\u3092\u898b\u308b<\/a>\n <\/div>\n <\/div>\n
    \n
    \n Catalog No. 21776 <\/a> <\/div>\n
    \n
    Vial Inserts, Glass, Big Mouth w\/Bottom Spring, 250 \u00b5L, 100-pk.<\/div>\n <\/div>\n
    \n \u88fd\u54c1\u60c5\u5831\u3092\u898b\u308b<\/a>\n <\/div>\n <\/div>\n
    \n
    \n Catalog No. 24498 <\/a> <\/div>\n
    \n
    Short Screw Cap, Polypropylene, Screw-Thread, PTFE\/Silicone\/PTFE Septa, Blue, Preassembled, 2.0 mL, 9 mm, 1000-pk.<\/div>\n <\/div>\n
    \n \u88fd\u54c1\u60c5\u5831\u3092\u898b\u308b<\/a>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n \n\n\n
    <\/div>\n","protected":false},"excerpt":{"rendered":"

    \u5168\u8840\u4e2d\u306e\u03948-THC\u30fb\u03949-THC\u304a\u3088\u3073\u305d\u306e\u4ee3\u8b1d\u7269\u3092\u5bfe\u8c61\u306b\u3001Raptor 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