{"id":43693,"date":"2021-01-11T00:00:00","date_gmt":"2021-01-11T00:00:00","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/japanese-lc-method-translation-will-switching-column-dimensions-speed-up-sample-analyses\/"},"modified":"2025-11-25T21:35:56","modified_gmt":"2025-11-25T21:35:56","slug":"japanese-lc-method-translation-will-switching-column-dimensions-speed-up-sample-analyses","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/ja\/articles-ja\/gnar3316-ja\/japanese-lc-method-translation-will-switching-column-dimensions-speed-up-sample-analyses","title":{"rendered":"LC\u30e1\u30bd\u30c3\u30c9\u5909\u63db: \u30ab\u30e9\u30e0\u30b5\u30a4\u30ba\u3092\u5909\u66f4\u3059\u308b\u3068\u3001\u30b5\u30f3\u30d7\u30eb\u5206\u6790\u3092\u9ad8\u901f\u5316\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u304b\uff1f"},"content":{"rendered":"\n

\u306f\u3058\u3081\u306b<\/h2>\n\n\n\n

\u30e1\u30bd\u30c3\u30c9\u5909\u63db\u306b\u3088\u308a\u5206\u6790\u6642\u9593\u3001\u6eb6\u5a92\u3001\u304a\u3088\u3073\u30b5\u30f3\u30d7\u30eb\u3092\u7bc0\u7d04\u3059\u308b\u3053\u3068\u306f\u3001\u6db2\u4f53\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc(LC)\u30e1\u30bd\u30c3\u30c9\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306e\u304d\u308f\u3081\u3066\u4e00\u822c\u7684\u306a\u65b9\u6cd5\u3067\u3059\u3002LC\u30e1\u30bd\u30c3\u30c9\u5909\u63db\u3067\u306f\u3001\u540c\u3058\u7c92\u5b50\u30bf\u30a4\u30d7(Raptor\u306a\u3069)\u3068\u56fa\u5b9a\u76f8(\u30d3\u30d5\u30a7\u30cb\u30eb\u306a\u3069)\u3092\u7dad\u6301\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u7c92\u5b50\u5f84\u304c\u5c0f\u3055\u304f\u3001\u77ed\u304f\u3066\u5185\u5f84\u306e\u7d30\u3044\u30ab\u30e9\u30e0\u3092\u4f7f\u7528\u3059\u308b\u3068\u3001\u8a31\u5bb9\u53ef\u80fd\u306a\u7d50\u679c\u3092\u4fdd\u3061\u306a\u304c\u3089\u3082\u5206\u6790\u3092\u30b9\u30d4\u30fc\u30c9\u30a2\u30c3\u30d7\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u5341\u5206\u306b\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30b5\u30f3\u30d7\u30eb\u30b9\u30eb\u30fc\u30d7\u30c3\u30c8\u306e\u5411\u4e0a\u304c\u3082\u305f\u3089\u3055\u308c\u3001\u5b9a\u671f\u7684\u306a\u30e1\u30f3\u30c6\u30ca\u30f3\u30b9\u306b\u6642\u9593\u3092\u5272\u304f\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u3055\u3089\u306b\u3088\u308a\u5c11\u91cf\u306e\u79fb\u52d5\u76f8\u3092\u7528\u3044\u308b\u8fc5\u901f\u306a\u30e1\u30bd\u30c3\u30c9\u304b\u3089\u3082\u305f\u3089\u3055\u308c\u308b\u5229\u70b9\u306e\u6069\u6075\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n\n\n\n

\u305f\u3060\u3057\u3001\u7279\u306b\u91cd\u8981\u306a\u30da\u30a2\u306e\u5b8c\u5168\u306a\u5206\u96e2\u304c\u4e0d\u53ef\u6b20\u306a\u5834\u5408\u306b\u306f\u3001\u30ab\u30e9\u30e0\u3092\u5909\u66f4\u3059\u308b\u3060\u3051\u3067\u306f\u3046\u307e\u304f\u3044\u304d\u307e\u305b\u3093\u3002\u91cd\u8981\u306a\u5206\u96e2\u3092\u640d\u306a\u3046\u3053\u3068\u306e\u306a\u3044\u3088\u3046\u306b\u3001\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u306b\u5408\u305b\u3066\u5206\u6790\u6761\u4ef6\u3092\u5909\u66f4\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u5f79\u7acb\u3064\u306e\u304cLC\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30f3\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3067\u3059\u3002<\/p>\n\n\n\n

\u77ed\u6642\u9593\u3067\u307b\u307c\u540c\u3058\u5206\u96e2\u3092\u304a\u3053\u306a\u3046\u3068\u3044\u3046\u76ee\u6a19\u3092\u9054\u6210\u3059\u308b\u306b\u306f\u3001\u30b5\u30a4\u30ba\u306f\u5c0f\u3055\u304f\u3068\u3082\u540c\u3058\u52b9\u7387\u3001\u3064\u307e\u308a\u307b\u307c\u540c\u7b49\u306e\u7406\u8ad6\u6bb5\u6570\u3092\u7dad\u6301\u3059\u308b\u30ab\u30e9\u30e0\u306b\u5909\u63db\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 \u3057\u304b\u3057\u3001\u5143\u306e\u30ab\u30e9\u30e0\u3068\u540c\u3058\u6bb5\u6570(\u00b110%)\u3092\u6709\u3059\u308b\u65b0\u305f\u306a\u30ab\u30e9\u30e0\u30b5\u30a4\u30ba\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u73fe\u5b9f\u7684\u3082\u3057\u304f\u306f\u53ef\u80fd\u3067\u3042\u308b\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002 \u3053\u308c\u306f\u5909\u63db\u3092\u6210\u529f\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u3068\u3044\u3046\u610f\u5473\u3067\u306f\u306a\u304f\u3001\u73fe\u5728\u306e\u5206\u96e2\u306b\u4f55\u3089\u304b\u306e\u5909\u5316\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002 \u65b0\u3057\u3044\u30ab\u30e9\u30e0\u3068\u30e1\u30bd\u30c3\u30c9\u306f\u3001\u3088\u308a\u77ed\u6642\u9593\u3067\u5206\u6790\u76ee\u6a19\u3092\u9054\u6210\u3059\u308b\u306e\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u3001\u30e1\u30bd\u30c3\u30c9\u5909\u63db\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u4f7f\u7528\u3057\u3066\u9078\u629e\u80a2\u3092\u691c\u8a0e\u3059\u308b\u4fa1\u5024\u306f\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

Restek\u306ePro EZ<\/em>LC\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u3092\u4f7f\u7528\u3057\u3066\u3001\u30e1\u30bd\u30c3\u30c9\u3092\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u306b\u5207\u308a\u66ff\u3048\u308b\u3053\u3068\u3067\u3001\u8cea\u306e\u826f\u3044\u7d50\u679c\u3092\u5f97\u3064\u3064\u6642\u9593\u3092\u7bc0\u7d04\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306e\u65b9\u6cd5\u3092\u898b\u3066\u3044\u304d\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n

LC\u30e1\u30bd\u30c3\u30c9\u5909\u63db\u306e\u30b7\u30ca\u30ea\u30aa<\/h2>\n\n\n\n

\u3053\u306e\u4f8b\u3067\u306f\u3001100mm\u00d73.0mm\u30012.7\u03bcm\u306eRaptor Biphenyl\u30ab\u30e9\u30e0\u3092\u7528\u3044\u308b\u30e1\u30bd\u30c3\u30c9\u306e\u958b\u767a\u306b\u3059\u3067\u306b\u6210\u529f\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u307e\u305f\u300150mm x2.1mm\u30012.7\u03bcm\u306e\u30ab\u30e9\u30e0\u304c\u81ea\u793e\u306b\u3042\u308a\u3001\u5c0f\u3055\u306a\u30b5\u30a4\u30ba\u306e\u30ab\u30e9\u30e0\u306b\u79fb\u884c\u3059\u308b\u3068\u3001\u5206\u6790\u6642\u9593\u304c\u77ed\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u77e5\u3063\u3066\u3044\u308b\u306e\u3067\u3001\u3088\u308a\u30b5\u30a4\u30ba\u306e\u5927\u304d\u306a\u30ab\u30e9\u30e0\u306b\u3088\u308b\u73fe\u884c\u306e\u30e1\u30bd\u30c3\u30c9\u304c\u3001\u3088\u308a\u77ed\u304f\u3001\u3088\u308a\u7d30\u3044\u30ab\u30e9\u30e0\u306b\u3046\u307e\u304f\u5909\u63db\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u77e5\u308a\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u3053\u306e\u7279\u5b9a\u306e\u30b1\u30fc\u30b9\u3067\u306f\u3001\u3088\u308a\u5c0f\u3055\u306a\u30ab\u30e9\u30e0\u306f\u3001\u7406\u8ad6\u6bb5\u6570\u5168\u4f53\u306b\u304a\u3051\u308b\u5927\u5e45\u306a\u640d\u5931\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u9069\u5207\u306a\u30e1\u30bd\u30c3\u30c9\u5909\u63db\u3067\u306f\u3001\u77ed\u6642\u9593\u3067\u540c\u3058\u5206\u96e2\u3092\u671f\u5f85\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u3057\u305f\u304c\u3063\u3066\u3001LC\u30e1\u30bd\u30c3\u30c9\u5909\u63db\u306e\u7d50\u679c\u3068\u3057\u3066\u91cd\u8981\u306a\u5206\u96e2\u80fd\u304c\u5931\u308f\u308c\u306a\u3044\u3088\u3046\u306b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 \u3057\u304b\u3057\u3001\u540c\u3058\u5206\u96e2\u304c\u5f97\u3089\u308c\u306a\u3044\u306b\u3057\u3066\u3082\u3001\u8a31\u5bb9\u53ef\u80fd\u306a\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u306e\u7d50\u679c\u3092\u5f97\u308b\u3053\u3068\u306f\u3067\u304d\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n\n\n\n

\u65b0\u3057\u3044\u30e1\u30bd\u30c3\u30c9\u6761\u4ef6\u3092\u8a08\u7b97\u3057\u3001\u65b0\u3057\u3044\u7d50\u679c\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u304c\u3001\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306e\u3042\u308b\u3079\u304d\u59ff\u3068\u3057\u3066\u8a2d\u8a08\u3055\u308c\u305f\u3082\u306e\u3067\u3059\u3002\u305d\u308c\u3067\u306f\u3001\u305d\u308c\u304c\u3069\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3059\u308b\u304b\u3092\u898b\u3066\u307f\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n

\u30e1\u30bd\u30c3\u30c9\u5909\u63db\u306e\u4f8b<\/h2>\n\n\n\n

\u7279\u5b9a\u306e\u4e71\u7528\u85ac\u7269\u5206\u6790\u3092\u4f8b\u306b\u3068\u308a\u307e\u3059\u3002\u5143\u306e\u9577\u3044\u30ab\u30e9\u30e0\u304c\u3082\u305f\u3089\u3059\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u306b\u6e80\u8db3\u3057\u3066\u3044\u3066\u3082\u3001\u3088\u308a\u5c0f\u3055\u306a\u30b5\u30a4\u30ba\u306e\u30ab\u30e9\u30e0\u306b\u5909\u63db\u3057\u3001\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u3092\u72a0\u7272\u306b\u3059\u308b\u3053\u3068\u306a\u304f\u5206\u6790\u6642\u9593\u3092\u77ed\u7e2e\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u78ba\u8a8d\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u300215\u7a2e\u985e\u306e\u4e71\u7528\u85ac\u7269\u306e\u3046\u3061\u3001MS\/MS\u3067\u533a\u5225\u3067\u304d\u306a\u3044\u305f\u3081\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u5206\u96e2\u304c\u5fc5\u8981\u306a\u540c\u91cd\u4f53\u304c\uff15\u7d44\u3042\u308a\u307e\u3059\u3002\u30aa\u30ea\u30b8\u30ca\u30eb\u30e1\u30bd\u30c3\u30c9\u304c\u5206\u96e2\u3067\u304d\u308b\u305f\u3081\u3001\u5909\u63db\u3055\u308c\u305f\u30e1\u30bd\u30c3\u30c9\u3082\u540c\u69d8\u306b\u6a5f\u80fd\u3059\u308b\u304b\u3069\u3046\u304b\u306b\u7279\u306b\u95a2\u5fc3\u304c\u304a\u304b\u308c\u307e\u3059\u3002 \u4e0b\u306e\u56f31\u306f\u3001100mm\u00d73.0mm\u3001\u7c92\u5b50\u5f842.7\u03bcm\u306e\u30ab\u30e9\u30e0\u306b\u3088\u308b\u30aa\u30ea\u30b8\u30ca\u30eb\u30e1\u30bd\u30c3\u30c9\u306e\u7d50\u679c\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n

\u56f3 1 :<\/strong>\u00a0\u30aa\u30ea\u30b8\u30ca\u30eb\u306e\u30ab\u30e9\u30e0\u30b5\u30a4\u30ba\u3068\u30e1\u30bd\u30c3\u30c9\u3092\u7528\u3044\u305f\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30e0\u3002<\/div>
\n
\"Original<\/div>

LC_CF0756<\/p>

Peaks<\/h4>\n
<\/th>Peaks<\/th>tR<\/sub> (min)<\/th>Precursor Ion<\/th>Product Ion<\/th><\/tr><\/thead>\n
1.<\/td>Morphine<\/a><\/td>1.11<\/td>286.2<\/td>152.1<\/td><\/tr>\n
2.<\/td>Hydromorphone<\/a><\/td>1.43<\/td>286.2<\/td>184.9<\/td><\/tr>\n
3.<\/td>Norcodeine<\/a><\/td>1.86<\/td>286.1<\/td>151.9<\/td><\/tr>\n
4.<\/td>Norhydrocodone<\/a><\/td>2.49<\/td>286.1<\/td>199.0<\/td><\/tr>\n
5.<\/td>6\u03b2-Naltrexol<\/a><\/td>3.32<\/td>344.3<\/td>326.1<\/td><\/tr>\n
6.<\/td>Tramadol<\/a><\/td>4.42<\/td>264.2<\/td>58.0<\/td><\/tr>\n
7.<\/td>Normeperidine<\/a><\/td>4.82<\/td>234.1<\/td>160.2<\/td><\/tr>\n<\/tbody><\/table>\n\n
<\/th>Peaks<\/th>tR<\/sub> (min)<\/th>Precursor Ion<\/th>Product Ion<\/th><\/tr><\/thead>
8.<\/td>Mirtazapine<\/a><\/td>5.50<\/td>266.1<\/td>195.1<\/td><\/tr>\n
9.<\/td>Clozapine<\/a><\/td>5.87<\/td>328.2<\/td>271.1<\/td><\/tr>\n
10.<\/td>Pentazocine<\/a><\/td>5.95<\/td>286.2<\/td>218.1<\/td><\/tr>\n
11.<\/td>7-Aminoflunitrazepam<\/a><\/td>6.50<\/td>284.1<\/td>135.0<\/td><\/tr>\n
12.<\/td>Fluoxetine<\/a><\/td>7.53<\/td>310.1<\/td>148.0<\/td><\/tr>\n
13.<\/td>Loxapine<\/a><\/td>7.86<\/td>328.1<\/td>271.1<\/td><\/tr>\n
14.<\/td>EMDP<\/a><\/td>8.28<\/td>264.2<\/td>235.2<\/td><\/tr>\n
15.<\/td>Thioridazine<\/a><\/td>8.87<\/td>371.2<\/td>126.1<\/td><\/tr>\n<\/tbody><\/table><\/div>

Conditions<\/h4>
Column<\/th>Raptor Biphenyl (cat.# 9309A1E<\/a>)<\/td><\/tr>
Dimensions:<\/th>100 mm x 3.0 mm ID<\/td><\/tr>
Particle Size:<\/th>2.7 \u00b5m<\/td><\/tr>
Pore Size:<\/th>90 \u00c5<\/td><\/tr>
<\/td>
Temp.:<\/th>40 \u00b0C<\/td><\/tr>
Standard\/Sample<\/th><\/td><\/tr>
Diluent:<\/th>Water<\/td><\/tr>
Conc.:<\/th>0.5-10 \u00b5g\/mL<\/td><\/tr><\/td><\/tr>
Inj. Vol.:<\/th>5 \u00b5L <\/td><\/tr>
Mobile Phase<\/th><\/td><\/tr>
A:<\/th>Water, 0.1% formic acid <\/td><\/tr>
B:<\/th>Methanol, 0.1% formic acid <\/td><\/tr>
<\/td>
Time (min)<\/th>Flow (mL\/min)<\/th>%A<\/th>%B<\/th><\/tr><\/thead>
0.00<\/td>1.0<\/td>85<\/td>15<\/td><\/tr>
6.50<\/td>1.0<\/td>50<\/td>50<\/td><\/tr>
10.00<\/td>1.0<\/td>0<\/td>100<\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/table>
Detector<\/th>MS\/MS<\/td><\/tr>
Ion Source:<\/th>Electrospray <\/td><\/tr>
Ion Mode:<\/th>ESI+ <\/td><\/tr>
Mode:<\/th>MRM <\/td><\/tr>
Instrument<\/th>UHPLC<\/td><\/tr>
Sample Preparation<\/th>A standard mix with 15 drugs of abuse was prepared in concentrations ranging from 500-10,000 ng\/mL in water. The solution was vortexed at 3000 rpm for 10 seconds to mix, and the supernatant was injected for LC-MS\/MS analysis.
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<\/path><\/g><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n
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\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u306f\u3001LC\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306b\u73fe\u5728\u306e\u30ab\u30e9\u30e0\u3068\u30e1\u30bd\u30c3\u30c9\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u5165\u529b\u3057\u3001\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u30b5\u30a4\u30ba\u306b\u6700\u9069\u306a\u30e1\u30bd\u30c3\u30c9\u3092\u63d0\u4f9b\u3067\u304d\u308b\u3088\u3046\u306b\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u3053\u306e\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u3092\u4f7f\u7528\u3059\u308b\u5834\u5408\u3001FPP\u304b\u3089FPP(\u5168\u591a\u5b54\u6027\u7c92\u5b50)\u307e\u305f\u306fSPP\u304b\u3089SPP(\u8868\u9762\u591a\u5b54\u6027\u7c92\u5b50)\u306a\u3069\u3001\u540c\u3058\u7c92\u5b50\u30bf\u30a4\u30d7\u306e\u30ab\u30e9\u30e0\u9593\u3067\u5909\u63db\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u306b\u6ce8\u610f\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u56f32\u306f\u3001\u5143\u306e\u30ab\u30e9\u30e0\u30b5\u30a4\u30ba\u3001\u6ce8\u5165\u91cf\u3001\u30c7\u30e5\u30a8\u30eb\u30dc\u30ea\u30e5\u30fc\u30e0\u3001\u300c\u30ab\u30e9\u30e0\u5916\u5bb9\u91cf\u300d\u5024\u3001\u304a\u3088\u3073\u79fb\u52d5\u76f8\u6761\u4ef6(\u3053\u306e\u30b1\u30fc\u30b9\u3067\u306f\u30b0\u30e9\u30b8\u30a8\u30f3\u30c8\u5206\u6790)\u304c\u5165\u529b\u3055\u308c\u305f\u72b6\u614b\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\u30c7\u30d5\u30a9\u30eb\u30c8\u306e\u30c7\u30e5\u30a8\u30eb\u30dc\u30ea\u30e5\u30fc\u30e0\u3068\u30ab\u30e9\u30e0\u5916\u5bb9\u91cf\u306e\u5024\u306b\u7279\u306b\u6ce8\u610f\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u3054\u4f7f\u7528\u306e\u6a5f\u5668\u306e\u5024\u3067\u306f\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5909\u63db\u3055\u308c\u305f\u5b9f\u884c\u6761\u4ef6\u4e0b\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u30da\u30a2\u306e\u5206\u96e2\u5ea6\u3084\u5316\u5408\u7269\u4fdd\u6301\u6642\u9593\u306a\u3069\u306e\u5024\u3092\u6c7a\u5b9a\u3059\u308b\u969b\u306b\u3001\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306f\u3053\u308c\u3089\u306e\u5024\u3092\u8003\u616e\u306b\u5165\u308c\u308b\u305f\u3081\u7279\u306b\u91cd\u8981\u3067\u3059\u3002 \u7279\u5b9a\u306e\u6a5f\u5668\u306b\u3064\u3044\u3066\u3053\u308c\u3089\u306e\u5024\u304c\u308f\u304b\u3089\u306a\u3044\u5834\u5408\u306f\u3001\u6a5f\u5668\u306e\u30de\u30cb\u30e5\u30a2\u30eb\u3067\u3053\u308c\u3089\u306e\u60c5\u5831\u3092\u8abf\u3079\u308b\u304b\u3001\u6a5f\u5668\u306e\u88fd\u9020\u5143\u306b\u554f\u3044\u5408\u308f\u305b\u308b\u304b\u3001\u307e\u305f\u306f\u3053\u308c\u3089\u306e\u5024\u3092\u7d4c\u9a13\u7684\u306b\u6c7a\u5b9a\u3059\u308b\u65b9\u6cd5\u3092\u304a\u8abf\u3079\u304f\u3060\u3055\u3044\u3002 \u3053\u308c\u3089\u306e\u5024\u306e\u8a73\u7d30\u306f\u3001\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306e\u7528\u8a9e\u96c6\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306e\u53f3\u4e0a\u9685\u306b\u3042\u308b\u300c?\u300d\u30dc\u30bf\u30f3\u3092\u30af\u30ea\u30c3\u30af\u3059\u308b\u3068\u30a2\u30af\u30bb\u30b9\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n

\u56f3 2:<\/strong>\u00a0LC\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u3092\u7528\u3044\u305f\u6700\u521d\u306e\u30b9\u30c6\u30c3\u30d7\uff1a\u73fe\u5728\u306e\u30ab\u30e9\u30e0\u3001\u6a5f\u5668\u3001\u30e1\u30bd\u30c3\u30c9\u306e\u60c5\u5831\u3092\u5165\u529b\u3002<\/div>
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\"graphical<\/figure>\n\n<\/div><\/div><\/div>\n\n\n
<\/div>\n\n\n\n

\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u306f\u3001\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u30b5\u30a4\u30ba\u3092\u6307\u5b9a\u3057\u3001\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306b\u305d\u306e\u4ed5\u4e8b\u3092\u3055\u305b\u308b\u3053\u3068\u3067\u3059\u3002\u56f33\u306f\u3001\u3053\u306e\u4f8b\u3067\u691c\u8a0e\u3057\u305f\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u3092\u5165\u529b\u3057\u305f\u72b6\u614b\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 \u65b0\u3057\u3044\u30ab\u30e9\u30e0\u60c5\u5831\u304c\u5165\u529b\u3055\u308c\u308b\u3068\u3001\u3053\u306e\u4f8b\u306e\u3088\u3046\u306b\u8b66\u544a\u30e1\u30c3\u30bb\u30fc\u30b8\u304c\u8868\u793a\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u306e\u8b66\u544a\u306f\u3001\u65b0\u3057\u3044\u30e1\u30bd\u30c3\u30c9\u6761\u4ef6\u4e0b\u3067\u306e\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u9078\u629e\u6027\u306e\u5909\u5316\u306e\u53ef\u80fd\u6027\u3092\u8b66\u544a\u3059\u308b\u305f\u3081\u306e\u3082\u306e\u3067\u3059(\u3053\u306e\u4f8b\u3067\u306f\u3001\u5f8c\u307b\u3069\u3053\u306e\u8b66\u544a\u304c\u9069\u7528\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3057\u307e\u3059)\u3002\u540c\u69d8\u306e\u9078\u629e\u6027\u3092\u5b9f\u73fe\u3059\u308b\u306b\u306f\u3001\u5909\u63db\u3055\u308c\u305f\u30e1\u30bd\u30c3\u30c9\u3092\u5143\u306e\u30e1\u30bd\u30c3\u30c9\u3067\u5316\u5408\u7269\u304c\u6eb6\u51fa\u3059\u308b\u79fb\u52d5\u76f8\u6761\u4ef6\u306b\u4e00\u81f4\u3055\u305b\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002 \u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306f\u3001\u5143\u306e\u30e1\u30bd\u30c3\u30c9\u3068\u540c\u3058\u79fb\u52d5\u76f8\u7d44\u6210\u3067\u5316\u5408\u7269\u3092\u6eb6\u51fa\u3055\u305b\u308b\u65b0\u3057\u3044\u79fb\u52d5\u76f8\u30b0\u30e9\u30b8\u30a8\u30f3\u30c8\u6761\u4ef6\u3092\u4f5c\u6210\u3057\u3088\u3046\u3068\u3057\u307e\u3059\u304c\u3001\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u30b5\u30a4\u30ba\u3067\u306f\u305d\u308c\u304c\u3067\u304d\u306a\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u5909\u63db\u3055\u308c\u305f\u30ab\u30e9\u30e0\u306e\u5bb9\u91cf\u304c\u5143\u306e\u30ab\u30e9\u30e0\u3068\u5927\u5e45\u306b\u7570\u306a\u308b\u5834\u5408\u3001\u30ab\u30e9\u30e0\u5185\u3067\u5143\u306e\u79fb\u52d5\u76f8\u7d44\u6210\u304c\u9054\u6210\u3055\u308c\u308b\u524d\u307e\u305f\u306f\u5f8c\u306b\u5316\u5408\u7269\u304c\u6eb6\u51fa\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5834\u5408\u3001\u7279\u306b\u521d\u671f\u306e\u6eb6\u51fa\u5316\u5408\u7269\u306f\u3001\u7570\u306a\u308bB\uff05\u6761\u4ef6\u4e0b\u3067\u6eb6\u51fa\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u9078\u629e\u6027\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u3053\u308c\u306b\u3064\u3044\u3066\u306e\u8a73\u7d30\u306f\u3001\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306e\u7528\u8a9e\u96c6\u3092\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u307e\u305f\u3001\u3053\u306e\u5f71\u97ff\u3092\u53ef\u8996\u5316\u3059\u308b\u305f\u3081\u306e\u7279\u5225\u306a\u30c1\u30e3\u30fc\u30c8\u3092\u542b\u3080\u3001\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u7248\u306ePro EZ<\/em>LC\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n

\u56f3 3 :<\/strong>\u00a0\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u306e\u30b5\u30a4\u30ba\u3092\u5165\u529b\u3002<\/div>
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\"\"<\/figure>\n\n<\/div><\/div><\/div>\n\n\n
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\u30dc\u30ea\u30e5\u30fc\u30e0\u52b9\u679c\u306e\u6d3b\u7528<\/h3>\n\n\n\n

\u56f34\u306f\u3001Pro EZ<\/em>LC\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u304c\u8a08\u7b97\u3057\u305f\u3001\u65b0\u3057\u304f\u8abf\u6574\u3055\u308c\u305f\u6ce8\u5165\u91cf\u3068\u30e1\u30bd\u30c3\u30c9\u306e\u72b6\u614b\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 \u540c\u3058\u6a5f\u5668\u3067\u65b0\u3057\u3044\u30e1\u30bd\u30c3\u30c9\u3092\u5b9f\u884c\u3059\u308b\u5834\u5408\u3001\u307b\u304b\u306e\u5909\u66f4\u3092\u52a0\u3048\u305a\u306b\u30c7\u30e5\u30a8\u30eb\u30dc\u30ea\u30e5\u30fc\u30e0\u3068\u30ab\u30e9\u30e0\u5916\u5bb9\u91cf\u306e\u5024\u3092\u540c\u3058\u306b\u4fdd\u3061\u307e\u3059\u3002 \u305f\u3060\u3057\u3001\u30e1\u30bd\u30c3\u30c9\u3092\u5225\u306e\u6a5f\u5668\u306b\u79fb\u3057\u305f\u308a\u3001\u4ed6\u306e\u5909\u66f4\u3092\u884c\u3046\u5834\u5408\u306f\u3001\u65b0\u3057\u3044\u5024\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n

\u56f3 4:<\/strong>\u00a0\u5143\u306e\u30e1\u30bd\u30c3\u30c9\u306e\u6eb6\u51fa\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3068\u4e00\u81f4\u3059\u308b\u3088\u3046\u306b\u3001\u5909\u63db\u3055\u308c\u305f\u6ce8\u5165\u91cf\u306f\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u306e\u30b5\u30a4\u30ba\u3068\u65b0\u3057\u3044\u30e1\u30bd\u30c3\u30c9\u6761\u4ef6\u306b\u5408\u305b\u3066\u8abf\u6574\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/div>
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\"graphical<\/figure>\n\n<\/div><\/div><\/div>\n\n\n
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\u307e\u305f\u3001Pro EZ<\/em>LC\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306f\u3001\u6307\u5b9a\u3055\u308c\u305f\u4e00\u9023\u306e\u30ab\u30e9\u30e0\u30b5\u30a4\u30ba\u306b\u5bfe\u3057\u3066\u7406\u60f3\u7684\u306a\u7bc4\u56f2\u5185\u306b\u3042\u308b\u6d41\u91cf\u306e\u307f\u3092\u8fd4\u305d\u3046\u3068\u3057\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u5b9f\u969b\u306b\u8a08\u7b97\u306b\u3088\u308a\u5909\u63db\u3055\u308c\u305f\u6d41\u91cf\u304c\u305d\u308c\u3089\u306e\u5024\u3092\u5916\u308c\u305f\u5834\u5408\u3001Pro EZ<\/em>LC\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306f\u3001\u6d41\u91cf\u304c\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u306b\u5bfe\u3057\u3066\u671b\u307e\u3057\u3044\u7bc4\u56f2\u5185\u306b\u306a\u308b\u3088\u3046\u306b\u8abf\u6574\u3057\u307e\u3059\u3002 \u3053\u306e\u6a5f\u80fd\u306e\u8a73\u7d30\u306b\u3064\u3044\u3066\u306f\u3001\u7528\u8a9e\u96c6\u3092\u53c2\u7167\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n

\u7d50\u679c\u306e\u89e3\u91c8<\/h3>\n\n\n\n

LC\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306e\u3053\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u3067\u306f\u3001\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u3092\u7528\u3044\u308b\u5909\u63db\u5f8c\u306e\u30e1\u30bd\u30c3\u30c9\u3067\u4e88\u60f3\u3055\u308c\u308b\u5206\u6790\u6642\u9593\u306e\u77ed\u7e2e\u3068\u80cc\u5727\u306e\u5909\u5316\u3092\u793a\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u30e6\u30fc\u30b6\u30fc\u56fa\u6709\u306e\u6ce8\u5165\u56de\u6570\u3067\u6642\u9593\u3068\u6eb6\u5a92\u306e\u7bc0\u7d04\u3092\u8a08\u7b97\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002 \u3053\u306e\u4f8b\u3067\u306f\u3001\u65b0\u3057\u3044\u30e1\u30bd\u30c3\u30c9\u304c\u534a\u5206\u306e\u5727\u529b\u3001\u534a\u5206\u306e\u5206\u6790\u6642\u9593\u3001\u305d\u3057\u3066\u5143\u306e\u30e1\u30bd\u30c3\u30c9\u306e1\/4\u306e\u6eb6\u5a92\u6d88\u8cbb\u91cf\u3067\u7d50\u679c\u3092\u751f\u6210\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u91cd\u8981\u306a\u5316\u5408\u7269\u306e\u9593\u306f\u307e\u3060\u5341\u5206\u306b\u5206\u96e2\u3057\u3066\u3044\u308b\u3067\u3057\u3087\u3046\u304b\uff1f \u300c\u91cd\u8981\u306a\u30d4\u30fc\u30af\u306e\u5206\u96e2\u5ea6\u300d\u3068\u300c\u5316\u5408\u7269\u306e\u4fdd\u6301\u6642\u9593\u300d\u306e\u30d5\u30a3\u30fc\u30eb\u30c9\u3067\u306f\u3001\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u3068\u30e1\u30bd\u30c3\u30c9\u304c\u8a31\u5bb9\u53ef\u80fd\u306a\u7d50\u679c\u3092\u63d0\u4f9b\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\u5143\u306e\u30e1\u30bd\u30c3\u30c9\u306e\u7d50\u679c\u3092\u518d\u78ba\u8a8d\u3059\u308b\u3068\u3001\u6700\u5c0f\u306e\u5206\u96e2\u5ea6\u3092\u6709\u3059\u308b\u91cd\u8981\u306a\u5316\u5408\u7269\u30da\u30a2\u306f\u30e2\u30eb\u30d2\u30cd(\u30d4\u30fc\u30af1)\u3068\u30d2\u30c9\u30ed\u30e2\u30eb\u30db\u30f3(\u30d4\u30fc\u30af2)\u3067\u3042\u308a\u3001\u5143\u306e\u5206\u96e2\u5ea6\u306f4.88\u3067\u3059\u3002 \u3053\u306e\uff12\u3064\u306e\u30d4\u30fc\u30af\u306f\u304b\u306a\u308a\u3088\u304f\u5206\u96e2\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u5143\u306e\u30ab\u30e9\u30e0\u3068\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u3068\u306e\u9593\u306e\u5168\u4f53\u7684\u306a\u52b9\u7387\u306e\u4f4e\u4e0b\u306f\u5206\u96e2\u3092\u72a0\u7272\u306b\u3057\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u4e88\u6e2c\u3067\u304d\u307e\u3059\u304c\u30014.88\u3068\u3044\u3046\u5143\u306e\u5206\u96e2\u5ea6\u3092\u9069\u5207\u306a\u30d5\u30a3\u30fc\u30eb\u30c9\u306b\u5165\u529b\u3057\u3001\u4e88\u6e2c\u5206\u96e2\u5ea6\u3092\u898b\u308b\u3060\u3051\u3067\u78ba\u8a8d\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059(\u56f35)\u3002 \u307e\u305f\u3001\u30e2\u30eb\u30d2\u30cd\u306e\u4fdd\u6301\u6642\u9593\u3092\u5165\u529b\u3057\u3066\u3001\u65b0\u3057\u3044\u6761\u4ef6\u4e0b\u3067\u4fdd\u6301\u6642\u9593\u304c\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u304b\u3092\u628a\u63e1\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n

\u56f3 5:<\/strong>\u00a0\u7d50\u679c\u306e\u30bb\u30af\u30b7\u30e7\u30f3\u3092\u5229\u7528\u3057\u3066\u3001\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u3068\u65b0\u3057\u3044\u30e1\u30bd\u30c3\u30c9\u6761\u4ef6\u4e0b\u3067\u91cd\u8981\u306a\u5206\u96e2\u5ea6\u3068\u4fdd\u6301\u6642\u9593\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002<\/div>
\n\n
\"graphical<\/figure>\n\n<\/div><\/div><\/div>\n\n\n
<\/div>\n\n\n\n

\u5168\u7406\u8ad6\u6bb5\u6570\u306e\u4f4e\u4e0b\u306b\u3088\u3063\u3066\u4e88\u6e2c\u3055\u308c\u305f\u3088\u3046\u306b\u3001\u3053\u306e\uff12\u3064\u306e\u91cd\u8981\u306a\u30da\u30a2\u306e\u9593\u306e\u5206\u96e2\u5ea6\u306f\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u304c\u3001\u65b0\u3057\u3044\u5206\u96e2\u5ea6\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5206\u96e2\u306b\u5fc5\u8981\u306a\u5024 (R = 1.5)\u3092\u306f\u308b\u304b\u306b\u8d85\u3048\u3066\u3044\u308b\u3053\u3068\u304c\u4e88\u6e2c\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3059\u3002 \u3053\u308c\u306b\u57fa\u3065\u3044\u3066\u3001\u5909\u63db\u3055\u308c\u305f\u6761\u4ef6\u3067\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u3092\u4f7f\u7528\u3057\u3066\u3082\u3001\u4e00\u756a\u65e9\u304f\u8fd1\u63a5\u3057\u3066\u6eb6\u51fa\u3059\u308b\u91cd\u8981\u306a\u5316\u5408\u7269\u30da\u30a2\u304c\u4f9d\u7136\u3068\u3057\u3066\u5206\u96e2\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u3001\u6b8b\u308a\u306e\u30af\u30ed\u30de\u30c8\u30b0\u30e9\u30d5\u30a3\u30fc\u5206\u96e2\u3082\u554f\u984c\u306a\u3044\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u7d50\u8ad6\u4ed8\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u304c\u3001\u7406\u8ad6\u3092\u305d\u306e\u307e\u307e\u306b\u3057\u3066\u306f\u3044\u3051\u307e\u305b\u3093\u3002<\/p>\n\n\n\n

\u56f36\u306f\u3001\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u30b5\u30a4\u30ba\u304a\u3088\u3073\u5909\u63db\u3055\u308c\u305f\u30e1\u30bd\u30c3\u30c9\u6761\u4ef6\u3092\u4f7f\u7528\u3057\u3066\u5206\u6790\u3055\u308c\u305f\u540c\u3058\u5316\u5408\u7269\u30bb\u30c3\u30c8\u306e\u5b9f\u9a13\u7d50\u679c\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n

\u56f3 6:<\/strong>\u00a0\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u3068\u5909\u63db\u5f8c\u306e\u30e1\u30bd\u30c3\u30c9\u6761\u4ef6\u3092\u7528\u3044\u3066\u751f\u6210\u3055\u308c\u305f\u5b9f\u9a13\u7d50\u679c\u3002<\/div>
\n
\"Translation<\/div>

LC_CF0757<\/p>

Peaks<\/h4>\n
<\/th>Peaks<\/th>tR<\/sub> (min)<\/th>Precursor Ion<\/th>Product Ion<\/th><\/tr><\/thead>\n
1.<\/td>Morphine<\/a><\/td>0.66<\/td>286.2<\/td>152.1<\/td><\/tr>\n
2.<\/td>Hydromorphone<\/a><\/td>0.88<\/td>286.2<\/td>184.9<\/td><\/tr>\n
3.<\/td>Norcodeine<\/a><\/td>1.15<\/td>286.1<\/td>151.9<\/td><\/tr>\n
4.<\/td>Norhydrocodone<\/a><\/td>1.51<\/td>286.1<\/td>199.0<\/td><\/tr>\n
5.<\/td>6\u03b2-Naltrexol<\/a><\/td>2.0<\/td>344.3<\/td>326.1<\/td><\/tr>\n
6.<\/td>Tramadol<\/a><\/td>2.55<\/td>264.2<\/td>58.0<\/td><\/tr>\n
7.<\/td>Normeperidine<\/a><\/td>2.74<\/td>234.1<\/td>160.2<\/td><\/tr>\n<\/tbody><\/table>\n\n
<\/th>Peaks<\/th>tR<\/sub> (min)<\/th>Precursor Ion<\/th>Product Ion<\/th><\/tr><\/thead>
8.<\/td>Mirtazapine<\/a><\/td>3.1<\/td>266.1<\/td>195.1<\/td><\/tr>\n
9.<\/td>Clozapine<\/a><\/td>3.26<\/td>328.2<\/td>271.1<\/td><\/tr>\n
10.<\/td>Pentazocine<\/a><\/td>3.3<\/td>286.2<\/td>218.1<\/td><\/tr>\n
11.<\/td>7-Aminoflunitrazepam<\/a><\/td>3.54<\/td>284.1<\/td>135.0<\/td><\/tr>\n
12.<\/td>Fluoxetine<\/a><\/td>4.02<\/td>310.1<\/td>148.0<\/td><\/tr>\n
13.<\/td>Loxapine<\/a><\/td>4.18<\/td>328.1<\/td>271.1<\/td><\/tr>\n
14.<\/td>EMDP<\/a><\/td>4.38<\/td>264.2<\/td>235.2<\/td><\/tr>\n
15.<\/td>Thioridazine<\/a><\/td>4.66<\/td>371.2<\/td>126.1<\/td><\/tr>\n<\/tbody><\/table><\/div>

Conditions<\/h4>
Column<\/th>Raptor Biphenyl (cat.# 9309A52<\/a>)<\/td><\/tr>
Dimensions:<\/th>50 mm x 2.1 mm ID<\/td><\/tr>
Particle Size:<\/th>2.7 \u00b5m<\/td><\/tr>
Pore Size:<\/th>90 \u00c5<\/td><\/tr>
<\/td>
Temp.:<\/th>40 \u00b0C<\/td><\/tr>
Standard\/Sample<\/th><\/td><\/tr>
Diluent:<\/th>Water<\/td><\/tr>
Conc.:<\/th>0.5-10 \u00b5g\/mL<\/td><\/tr><\/td><\/tr>
Inj. Vol.:<\/th>1 \u00b5L <\/td><\/tr>
Mobile Phase<\/th><\/td><\/tr>
A:<\/th>Water, 0.1% formic acid <\/td><\/tr>
B:<\/th>Methanol, 0.1% formic acid <\/td><\/tr>
<\/td>
Time (min)<\/th>Flow (mL\/min)<\/th>%A<\/th>%B<\/th><\/tr><\/thead>
0.00<\/td>0.5<\/td>85<\/td>15<\/td><\/tr>
3.20<\/td>0.5<\/td>50<\/td>50<\/td><\/tr>
4.90<\/td>0.5<\/td>0<\/td>100<\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/table>
Detector<\/th>MS\/MS<\/td><\/tr>
Ion Source:<\/th>Electrospray <\/td><\/tr>
Ion Mode:<\/th>ESI+ <\/td><\/tr>
Mode:<\/th>MRM <\/td><\/tr>
Instrument<\/th>UHPLC<\/td><\/tr>
Sample Preparation<\/th>A standard mix with 15 drugs of abuse was prepared in the concentrations ranging from 500-10,000 ng\/mL in water. The solution was vortexed at 3000 rpm for 10 seconds to mix, and the supernatant was injected for LC-MS\/MS analysis.<\/td><\/tr><\/table><\/div><\/div><\/div>
<\/path><\/g><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n
<\/div>\n\n\n\n

\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u3068\u30e1\u30bd\u30c3\u30c9\u3092\u4f7f\u7528\u3057\u305f\u5b9f\u969b\u306e\u5206\u6790\u3067\u306f\u3001\u30e2\u30eb\u30d2\u30cd\u306e\u4fdd\u6301\u6642\u9593\u306f0.66\u5206\u3067\u3042\u308a\u3001LC\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306e\u4e88\u6e2c\u4fdd\u6301\u6642\u9593\u3088\u308a\u3082\u308f\u305a\u304b0.01\u5206\u9577\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002 \u30e2\u30eb\u30d2\u30cd\u3068\u30d2\u30c9\u30ed\u30e2\u30eb\u30db\u30f3\u3068\u306e\u9593\u306e\u5206\u96e2\u5ea6\u306f\u3001R=3.07\u3067\u3042\u308b\u3068\u5b9f\u9a13\u7684\u306b\u6c7a\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u4e88\u6e2c\u5206\u96e2\u5ea6\u306fR=2.80\u3067\u3001\u304a\u3088\u305d10%\u306e\u9055\u3044\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u91cd\u8981\u306a\u30da\u30a2\u306e\u5206\u96e2\u5ea6\u306b\u95a2\u3057\u3066\u306f\u3001\u63a7\u3048\u3081\u306a\u65b9\u5411\u3067\u8aa4\u308a\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u4e88\u6e2c\u3088\u308a\u3082\u3055\u3089\u306b\u512a\u308c\u305f\u5206\u96e2\u80fd\u3092\u793a\u3059\u5b9f\u9a13\u7d50\u679c\u3068\u306a\u308a\u3001\u3053\u306e\u4f8b\u3067\u306f\u3001\u91cd\u8981\u306a\u30da\u30a2\u306e\u5206\u96e2\u3092\u640d\u3046\u3053\u3068\u3092\u61f8\u5ff5\u305b\u305a\u306b\u3001\u5143\u306e\u30ab\u30e9\u30e0\u304b\u3089\u79fb\u884c\u3057\u3066\u65b0\u3057\u3044\u30ab\u30e9\u30e0\u3068\u5909\u63db\u3055\u308c\u305f\u30e1\u30bd\u30c3\u30c9\u6761\u4ef6\u3092\u63a1\u7528\u3057\u3066\u3082\u5b89\u5168\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\u4e00\u65b9\u3001\u91cd\u8981\u306a\u30da\u30a2\u304c\u5143\u306e\u6761\u4ef6\u4e0b\u3067R=2\u306e\u5206\u96e2\u5ea6\u3092\u6709\u3057\u3066\u3044\u305f\u5834\u5408\u3001\u3053\u306e\u7279\u5b9a\u306e\u5909\u63db(100mm\u00d73.0mm\u30012.7\u03bcm\u304b\u308950mm\u00d72.1mm\u30012.7\u03bcm)\u306f\u3001\u5909\u63db\u6761\u4ef6\u4e0b\u3067\u306f\u5171\u6eb6\u51fa\u3092\u56de\u907f\u3059\u308b\u306e\u306b\u5341\u5206\u306a\u5206\u96e2\u5ea6\u3092\u6709\u3057\u3066\u3044\u306a\u3044\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3067\u3057\u3087\u3046(\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u306f\u3001\u3053\u308c\u3089\u306e\u6761\u4ef6\u4e0b\u3067R=1.15\u3092\u4e88\u6e2c\u3057\u307e\u3059)\u3002<\/p>\n\n\n\n

\u307e\u3068\u3081<\/h2>\n\n\n\n

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\u3042\u306a\u305f\u306e\u30e9\u30dc\u306b\u306f\u30e1\u30bd\u30c3\u30c9\u5909\u63db\u306e\u9700\u8981\u306f\u3042\u308a\u307e\u3059\u304b? \u305d\u306e\u5834\u5408\u306f\u3001Restek Pro EZLC\u30e1\u30bd\u30c3\u30c9\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30bf\u3092\u3054\u78ba\u8a8d\u304f\u3060\u3055\u3044\u3002\u3054\u4e0d\u660e\u306a\u70b9\u304c\u3042\u308a\u307e\u3057\u305f\u3089\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044\u3002 \u30e1\u30bd\u30c3\u30c9\u5909\u63db\u304c\u3046\u307e\u304f\u3044\u304d\u307e\u3059\u3088\u3046\u306b\uff01<\/p>\n\n\n\n

<\/div>\n\n\n
\n

Products Mentioned<\/h3>\n
\n
\n
\n
\n Catalog No. 9309A1E <\/a> <\/div>\n
\n
Raptor Biphenyl, 2.7 \u00b5m, 100 x 3.0 mm HPLC\u30ab\u30e9\u30e0<\/div>\n <\/div>\n
\n \u88fd\u54c1\u60c5\u5831\u3092\u898b\u308b<\/a>\n <\/div>\n <\/div>\n
\n
\n Catalog No. 9309A52 <\/a> <\/div>\n
\n
Raptor Biphenyl, 2.7 \u00b5m, 50 x 2.1 mm HPLC\u30ab\u30e9\u30e0<\/div>\n <\/div>\n
\n \u88fd\u54c1\u60c5\u5831\u3092\u898b\u308b<\/a>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n \n\n\n
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