Posters & Presentations

The Development of a Virtual Liquid Chromatography Method Development Tool

22 Jan 2026

Laboratories implementing new methods or optimizing existing methods for improved profitability and efficiency, struggle with instrument availability and the time needed to do hands on traditional method development work.

The development and optimization of a Liquid Chromatography (LC) method can be time consuming and costly. Often this requires a number of steps including literature research, column selection, method scouting, development and optimization. To alleviate the burden of sacrificing instrument-uptime, labor, and materials, an instrument-free software modeling tool was developed with a comprehensive Drugs of Abuse library (DoA). This no-cost tool allows users to obtain optimized separations while maintaining critical pair resolution by adjusting parameters such as column dimension, mobile phase, gradients, and more.

Authors

  • Melinda Ulrich

    Melinda “Mel” Urich is an applications scientist in the LC Solutions department. Her primary focus is on the development of novel applications in the cannabis and food markets. In her previous role at Restek as an LC manufacturing chemist, she led the synthesis of silica, bonding of stationary phases as well as new process implementations and improvements. Mel attended Juniata College where she earned her BS in Chemistry and performed research in Atomic Force Microscopy AFM).

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  • Jamie York is a principal scientist in the Applications Lab at Restek Corporation. She leads the development of innovative analytical methods tailored to the food, clinical, environmental, and cannabis markets. Jamie earned her PhD in chemistry from The University of Texas at Arlington, where she gained extensive expertise in a range of analytical techniques, including gas chromatography–vacuum ultraviolet (GC–VUV); gas chromatography–mass spectrometry (GC–MS); matrix-assisted laser desorption/ionization (MALDI); and liquid chromatography– mass spectrometry (LC–MS/MS); with a research emphasis on food and environmental analysis. Today, her work focuses on complex method development and advanced sample preparation strategies to support the evolving needs of the scientific community.  

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  • Justin Steimling
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