Comprehensive Review of Low-Pressure Gas Chromatography Applications

Low-Pressure GC (LPGC technique) has been successfully used for the analysis of pesticide residues; monochloropropane diols (MCPDs); phthalates; arylamines; nitrosamines; and alkylamines, as examples. In addition to these applications, a variety of different stationary phases have been evaluated to include “5-type,” high phenyl-type, trifluoropropyl, and cyano-phenyl columns. Applications have demonstrated that using both 0.53 mm internal diameter columns, as well as 0.32 mm internal diameter columns, can be successfully used for many different applications. The use of Concurrent Solvent Recondensation Large Volume splitless injection (CSR-LVSI) has been used with LPGC injecting up to 25 μL with significant increases in sensitivity and minimal peak distortion. The LPGC techniques provided reductions in run times (up to 3.3x faster runs) and helium consumption reduction (up to 81% less helium used), while keeping an acceptable resolution. This presentation will review applications, use of different column dimensions and phases, and will review the ability to inject large volumes to increase sensitivity.