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Vial Septum Selection Guide

21 Oct 2020

figure article GNOT3420 01
Materials Compatability Incompatibility Resealability Max. Temp.
Red Rubber (synthetic) acetone, alcohols, DMF, DMSO, ether ACN, benzene, chloroform, heptane, hexane, pyridine, THF, toluene very good 90°
PTFE/Natural Rubber PTFE: resistance until punctured
Rubber: acetone, ACN, alcohols, diethylamine, DMF, DMSO, phenol
aromatics, carbon disulfide, chlorinated solvents, hydrocarbon solvents very good 90°
PTFE/Silicone
PTFE/Silicone/PTFE
PTFE: resistance until punctured
Silicone: acetone, alcohols, DMF, DMSO, ether
ACN, benzene, chloroform, heptane, hexane, pyridine, THF, toluene very good 205°
Polyethylene Good resistance to solvents and weak acids or bases. Unreactive with most chemicals, but some solvents cause softening or swelling. hydrocarbon solvents one-time use 175°
Gray Chlorobutyl acids or bases, water solutions, buffer solutions, oxygenated solvents, vegetable oils aliphatic or aromatic hydrocarbons, halogenated solvents, mineral oils, strong acids very good 100°

Abbreviations:
ACN – acetonitrile
DMF – dimethylformamide
DMSO – dimethylsulfoxide
THF – tetrahydrofuran

NOTE: This chemical resistance chart is intended only as a guideline. It does not cover all compounds or all solvents. Tests were done at room temperature on pure solvents, and there is no data if two or more compounds are involved. Always confirm the compatibility of your vial, closure, and chemical combination prior to sample preparations.

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  • Restek Corporation

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GNOT3420