LPGC-MS is a technique that allows GC-MS users to leverage the vacuum system of their MS, along with a specially designed column kit, to significantly speed up their analysis. By using a 0.53 or 0.32 mm analytical column that is inserted directly into the MS and a flow restrictor on the GC inlet side, one can benefit from low pressure created inside the analytical column. Using this LPGC-MS technique, some efficiency is traded for speed. But, because a mass spectrometer is used, most coeluting components can be deconvoluted by the MS. You can learn more about how LPGC-MS works and whether it is a good fit for your lab in this technical article or by contacting your Restek representative.
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