Efficiency is key in toxicology laboratories where multiple drug panels must be run daily. Consolidating multiple drug panels into large, multi-class drug assays can streamline the analytical testing process and reduce operating costs. To simplify the analysis of alcohol metabolites, barbiturates, THC metabolites, and drugs of abuse, three different LC-MS/MS methods were developed for each analyte class using the same analytical column and mobile phases.
A panel of 100 drugs of abuse, novel psychoactive substances, therapeutic drugs and metabolites, a panel of biomarkers of alcohol consumption, and a panel of barbiturates and cannabinoid metabolites were all analyzed using the same analytical column and mobile phase set up.
This work highlights the ability of one LC-MS/MS setup to analyze multiple toxicology panels. This allows for laboratories to simplify testing procedures, save time, and reduce operating costs.
