{"id":103488,"date":"2020-10-14T14:30:00","date_gmt":"2020-10-14T14:30:00","guid":{"rendered":"https:\/\/discover.restek.com\/?p=103488"},"modified":"2026-09-16T06:22:53","modified_gmt":"2026-09-16T06:22:53","slug":"synthetic-cannabinoids-metabolites-lc-ms","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/zh-hans\/application-notes-zh\/synthetic-cannabinoids-metabolites-lc-ms\/","title":{"rendered":"\u5408\u6210\u5927\u9ebb\u7d20\u53ca\u5176\u4ee3\u8c22\u7269\u5206\u6790\uff1a\u7528\u73b0\u6709LC-MS\/MS \u65b9\u6cd5\u5206\u6790\u66f4\u591a\u65b0\u578b\u5316\u5408\u7269"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u6458\u8981<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u622a\u6b622020\u5e74\u5e95\uff0c\u5168\u7403\u5df2\u51fa\u73b0\u65b0\u7cbe\u795e\u6d3b\u6027\u7269\u8d281047\u79cd\uff0c\u5176\u4e2d\u7ea6450\u79cd\u4e3a\u8fd15\u5e74\u65b0\u51fa\u73b0\u7684\u79cd\u7c7b\u3002\u6211\u56fd\u5df2\u7d2f\u8ba1\u53d1\u73b0\u65b0\u7cbe\u795e\u6d3b\u6027\u7269\u8d289\u5927\u7c7b317\u79cd\uff0c\u8fd13\u5e74\u65b0\u53d1\u73b050\u4f59\u79cd\u3002\u81f32024\u5e74\u5e95\u6211\u56fd\u5df2\u5217\u7ba1509\u79cd\u9ebb\u9189\u54c1\u548c\u7cbe\u795e\u7269\u8d28\uff08\u5305\u62ec123\u79cd\u9ebb\u9189\u836f\u54c1\u3001166\u79cd\u7cbe\u795e\u836f\u54c1\u3001220\u79cd\u975e\u836f\u7528\u7c7b\u9ebb\u9189\u836f\u54c1\u548c\u7cbe\u795e\u836f\u54c1\uff09\uff0c\u6574\u7c7b\u5217\u7ba1\u82ac\u592a\u5c3c\u7c7b\u7269\u8d28\u3001\u5408\u6210\u5927\u9ebb\u7d20\u7c7b\u7269\u8d28\uff0c\u662f\u4e16\u754c\u4e0a\u5217\u7ba1\u6bd2\u54c1\u6700\u591a\u3001\u7ba1\u5236\u6700\u4e25\u7684\u56fd\u5bb6\u3002\u5206\u6790\u68c0\u6d4b\u4e0d\u65ad\u51fa\u73b0\u7684\u975e\u6cd5\u5408\u6210\u5927\u9ebb\u7d20\u53ca\u5176\u4ee3\u8c22\u7269\uff0c\u6210\u4e3a\u4e00\u9879\u8270\u5de8\u4e14\u5177\u6709\u6311\u6218\u6027\u7684\u4efb\u52a1\u3002\u5728\u6b64\uff0c\u6211\u4eec\u5c06\u5411\u5927\u5bb6\u5c55\u793aRaptor Biphenyl \u8054\u82ef\u6838\u58f3\u67f1\u7684\u826f\u597d\u4fdd\u7559\u80fd\u529b\u548c\u9009\u62e9\u6027\uff0c\u4f7f\u7528\u5df2\u6709\u5206\u6790\u65b9\u6cd5\uff0c\u5373\u53ef\u5206\u6790\u66f4\u591a\u65b0\u578b\u5316\u5408\u7269\uff0c\u8be5\u65b9\u6cd5\u6709\u52a9\u4e8e\u63d0\u9ad8\u5b9e\u9a8c\u5ba4\u68c0\u6d4b\u6548\u7387\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u8a00<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u968f\u7740\u5404\u79cd\u65b0\u578b\u5408\u6210\u5927\u9ebb\u7d20\u7c7b\u7269\u8d28\u7684\u51fa\u73b0\uff0c\u5408\u6210\u5927\u9ebb\u7d20\u53ca\u4ee3\u8c22\u7269\u7684\u5206\u6790\u5df2\u6210\u4e3a\u8bb8\u591a\u6cd5\u533b\u6bd2\u7406\u5b9e\u9a8c\u5ba4\u7684\u5e38\u89c4\u5206\u6790\u9879\u76ee\u3002\u5728\u5f00\u53d1\u8be5\u7c7b\u5316\u5408\u7269\u5206\u6790\u65b9\u6cd5\u65f6\uff0c\u9700\u8981\u7efc\u5408\u517c\u987e\u5206\u6790\u65f6\u95f4\u3001\u5404\u5f85\u6d4b\u7269\u4e4b\u95f4\u7684\u5206\u79bb\u5ea6\u3001\u65b9\u6cd5\u7684\u7a33\u5b9a\u6027\u53ca\u5bf9\u65b0\u589e\u5206\u6790\u7269\u7684\u5bb9\u7eb3\u80fd\u529b\uff0c\u8fd9\u4e9b\u56e0\u7d20\u5c06\u76f4\u63a5\u5f71\u54cd\u65b9\u6cd5\u7684\u6709\u6548\u6027\u548c\u8010\u7528\u6027\u3002Raptor Biphenyl\u8054\u82ef\u6838\u58f3\u67f1\u7ed3\u5408\u4e86\u6838\u58f3\u9897\u7c92\u5feb\u901f\u5206\u6790\u4e0e\u8054\u82ef\u56fa\u5b9a\u76f8\u9ad8\u9009\u62e9\u6027\u9ad8\u5206\u8fa8\u529b\uff0c\u6210\u4e3a\u5927\u9ebb\u7d20\u7c7b\u7269\u8d28\u5206\u6790\u7684\u9996\u9009\u8272\u8c31\u67f1\u3002\u6211\u4eec\u5f00\u53d1\u4e86\u4e00\u79cd\u53ea\u9700\u7b80\u5355\u7a00\u91ca\u5373\u53ef\u76f4\u63a5\u8fdb\u6837\u7684\u5206\u6790\u65b9\u6cd5\u6765\u68c0\u6d4b\u5c3f\u6db2\u4e2d\u7684\u5408\u6210\u5927\u9ebb\u7d20\u53ca\u4ee3\u8c22\u7269\uff0c\u8fd9\u9879\u521b\u65b0\u6027\u5de5\u4f5c\uff0c\u53ef\u5728\u4e0d\u52307\u5206\u949f\u65f6\u95f4\u5185\u5b8c\u621029\u79cd\u76ee\u6807\u7269\u7684\u5206\u79bb\u548c\u68c0\u6d4b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5206\u6790\u5408\u6210\u5927\u9ebb\u7d20\u65f6\uff0c\u8272\u8c31\u5206\u79bb\u67d0\u4e9b\u65e0\u6cd5\u4ec5\u901a\u8fc7MS\u5b9a\u6027\u7684\u5316\u5408\u7269\u81f3\u5173\u91cd\u8981\u3002\u4f8b\u5982\uff1a\u5408\u6210\u5927\u9ebb\u7d20JWH-018\u548cJWH-073\u53ca\u5176\u4ee3\u8c22\u7269\u5fc5\u987b\u901a\u8fc7\u8272\u8c31\u5206\u79bb\uff0c\u7531\u4e8e\u6bcd\u4f53\u5316\u5408\u7269\u6709\u591a\u4e2a\u53ef\u7528\u4e8e\u7f9f\u57fa\u5316\u7684\u4f4d\u70b9\uff08\u56fe1\uff09\uff0c\u9020\u6210\u5b83\u4eec\u7684\u5355\u7f9f\u57fa\u5316\u4ee3\u8c22\u7269\u5b58\u5728\u591a\u4e2a\u4f4d\u7f6e\u5f02\u6784\u4f53\u3002\u65b9\u6cd5\u4e2d\u76ee\u6807\u5316\u5408\u7269\u79cd\u7c7b\u8d8a\u591a\uff0c\u83b7\u5f97\u8db3\u591f\u5206\u8fa8\u7387\u7684\u96be\u5ea6\u5c31\u8d8a\u5927\u3002\u5728\u6b64\uff0c\u6211\u4eec\u6269\u5c55\u4e86\u521d\u59cb\u65b9\u6cd5\uff0c\u5e76\u6f14\u793a\u5728\u4fdd\u8bc1\u5206\u8fa8\u7387\u3001\u907f\u514d\u57fa\u8d28\u5e72\u6270\u7684\u60c5\u51b5\u4e0b\u5c06\u65b0\u5316\u5408\u7269\u6dfb\u52a0\u5230\u65b9\u6cd5\u4e2d\u3002\u5c06\u65b0\u5174\u5316\u5408\u7269\u6dfb\u52a0\u5230\u539f\u6709\u65b9\u6cd5\u4e2d\u7684\u610f\u4e49\u5728\u4e8e\uff1a\u9762\u4e34\u65b0\u589e\u5316\u5408\u7269\u7684\u5206\u6790\u9700\u6c42\u65f6\uff0c\u5b9e\u9a8c\u5ba4\u7684\u8272\u8c31\u5de5\u4f5c\u8005\u53ef\u4ee5\u4e13\u6ce8\u4e8e\u5e38\u89c4\u6837\u54c1\u5206\u6790\uff0c\u800c\u65e0\u987b\u8017\u8d39\u5927\u91cf\u65f6\u95f4\u548c\u7cbe\u529b\u5f00\u53d1\u65b0\u65b9\u6cd5\u3002<\/p>\n\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\">\u56fe 1: \u5408\u6210\u5927\u9ebb\u7d20\u7684\u5206\u6790\u56e0 JWH-018 \u5b58\u5728\u591a\u4e2a\u7f9f\u57fa\u5316\u4f4d\u70b9\u800c\u53d8\u5f97\u590d\u6742\u3002<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-FFAN2614-01.jpg\" alt=\"a diagram of a question mark\" title=\"-\"><\/figure>\n\n<\/div><\/div><\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b9e\u9a8c<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u5c3f\u6db2\u4e3a\u6eb6\u5242\u5236\u5907\u6837\u54c1\uff0c\u5206\u6790\u524d\uff0c\u5728 0.2\u03bcm PVDF Thomson SINGLE StEP \u8fc7\u6ee4\u74f6\u4e2d\u7528\u6c34\uff1a\u7532\u9187\uff0850\uff1a50\uff09\u7a00\u91ca3\u500d\u5f85\u7528\u3002\u4f7f\u7528\u539f\u6709\u65b9\u6cd5\u4e2d\u7684Raptor Biphenyl\u8054\u82ef\u67f1\u4f5c\u4e3a\u5206\u6790\u67f1\u3002\u8bc4\u4f30\u662f\u5728\u914d\u5907 Xevo TQ-S \u7684 Waters ACQUITY UPLC I-Class\uff0c\u548c\u914d\u5907 SCIEX API 4500 MS\/MS \u7684Shimadzu Nexera UHPLC \u4e0a\u8fdb\u884c\u7684\u3002\u4e24\u79cd\u7cfb\u7edf\u90fd\u4f7f\u7528\u591a\u53cd\u5e94\u76d1\u6d4b\uff08MRM\uff09\u626b\u63cf\u6a21\u5f0f\uff0c\u79bb\u5b50\u5316\u65b9\u5f0f\u4e3aESI+\u3002\u4eea\u5668\u6761\u4ef6\u5982\u4e0b\uff0c\u56fe\u4e2d\u63d0\u4f9b\u4e86\u539f\u59cb\u76ee\u6807\u7269\u548c\u5176\u5b83\u611f\u5174\u8da3\u7684\u65b0\u6dfb\u52a0\u5316\u5408\u7269\u4e24\u4e2a\u5206\u6790\u7269\u7c7b\u522b\u3002<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>\u5206\u6790\u67f1:<\/td><td>Raptor Biphenyl (2.7 \u03bcm, 50 mm x 3.0 mm; \u8d27\u53f79309A5E)<\/td><\/tr><tr><td>\u4fdd\u62a4\u67f1:<\/td><td>Raptor Biphenyl EXP \u4fdd\u62a4\u67f1\u82af (2.7 \u03bcm, 5 mm x 3.0 mm;\u8d27\u53f79309A0253)<\/td><\/tr><tr><td>\u6d41\u52a8\u76f8 A:<\/td><td>\u6c34\uff080.1%\u7532\u9178\uff09<\/td><\/tr><tr><td>\u6d41\u52a8\u76f8 B:<\/td><td>\u4e59\u8148\uff080.1%\u7532\u9178\uff09<\/td><\/tr><tr><td>\u68af\u5ea6<\/td><td>T\u65f6\u95f4 (min) &nbsp;&nbsp;&nbsp;&nbsp;%B<\/td><\/tr><tr><td>&nbsp;<\/td><td>0.00&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;25<\/td><\/tr><tr><td>&nbsp;<\/td><td>1.00&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;25<\/td><\/tr><tr><td>&nbsp;<\/td><td>5.00&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;95<\/td><\/tr><tr><td>&nbsp;<\/td><td>5.50&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;95<\/td><\/tr><tr><td>&nbsp;<\/td><td>5.51&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;25<\/td><\/tr><tr><td>&nbsp;<\/td><td>7.00&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;25<\/td><\/tr><tr><td>\u6d41\u901f:<\/td><td>0.6 mL\/min<\/td><\/tr><tr><td>\u8fdb\u6837\u91cf:<\/td><td>2 \u00b5L<\/td><\/tr><tr><td>\u67f1\u6e29:<\/td><td>30 \u00b0C<\/td><\/tr><tr><td>\u79bb\u5b50\u5316\u65b9\u5f0f:<\/td><td>ESI+<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7ed3\u679c\u4e0e\u8ba8\u8bba<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4eca\u5929\uff0c\u5b9e\u9a8c\u5ba4\u9762\u4e34\u7740\u4e00\u9879\u8270\u5de8\u7684\u4efb\u52a1\uff0c\u5373\u8ddf\u4e0a\u975e\u6cd5\u5236\u836f\u5546\u4e3a\u89c4\u907f\u68c0\u6d4b\u800c\u751f\u4ea7\u7684\u4e0d\u65ad\u65b0\u589e\u7684\u5408\u6210\u5927\u9ebb\u7d20\u7c7b\u7269\u8d28\u3002\u6b64\u524d\uff0c\u6211\u4eec\u5efa\u7acb\u4e86\u4e00\u79cd\u68c0\u6d4b\u5c3f\u6db2\u4e2d17\u79cd\u5408\u6210\u5927\u9ebb\u7d20\u300112\u79cd\u4ee3\u8c22\u7269\u548c5\u79cd\u5185\u6807\uff08\u6d53\u5ea6\u6c34\u5e735ng\/mL\uff09\u7684\u5206\u6790\u65b9\u6cd5\u3002\u7531\u4e8eRaptor Biphenyl\u8054\u82ef\u8272\u8c31\u67f1\u72ec\u7279\u7684\u9009\u62e9\u6027\u548c\u4fdd\u7559\u80fd\u529b\uff0c\u8be5\u65b9\u6cd5\u57285\u5206\u949f\u7684\u5faa\u73af\u65f6\u95f4\u548c7\u5206\u949f\u7684\u603b\u5206\u6790\u65f6\u95f4\u5185\u5b9e\u73b0\u4e86\u5f02\u6784\u4f53\u7684\u5b8c\u5168\u5206\u79bb\u3002\u5e76\u4e14\u4e0e\u4e3b\u8981\u57fa\u8d28\u5e72\u6270\u7269\u6709\u826f\u597d\u5206\u79bb\uff0c\u907f\u514d\u4e86\u57fa\u8d28\u5e72\u6270\uff08\u56fe2\uff09\u3002<\/p>\n\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\">\u56fe 2: \u5206\u6790\u5c3f\u6db2\u4e2d\u5408\u6210\u5927\u9ebb\u7d20\u548c\u4ee3\u8c22\u7269\u800c\u5f00\u53d1\u7684\u539f\u59cb\u65b9\u6cd5<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<div class=\"wp-block-custom-chromatogram-article\"><div class=\"wp-block-custom-chromatogram-article\"><div class=\"chromatogram-image regular-image\"><img decoding=\"async\" src=\"https:\/\/ez.restek.com\/images\/cgram\/lc_cf0613.png\" alt=\"Combined Analysis of Synthetic Cannabinoids &amp; Metabolites in Urine by LC-MS\/MS on Raptor Biphenyl\" title=\"-\"><\/div><p class=\"article-id\" style=\"text-align:center\"> LC_CF0613<\/p><div class=\"chromatogram-peaks\"><h4>Peaks<\/h4><table class=\"peaks col-lg-6 col-12 peak-50\">\n<thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> (min)<\/th><th style=\"text-align: center;width: 75px\">Precursor Ion<\/th><th style=\"text-align: center;width: 75px\">Quantifier Product Ion <\/th><th style=\"text-align: center;width: 75px\">Qualifier Product Ion<\/th><\/tr><\/thead>\n<tbody><tr><td class=\"num\">1.<\/td><td class=\"cmpd\">Pravadoline<\/td><td class=\"oth\">2.15<\/td><td class=\"oth\">379.29<\/td><td class=\"oth\">135.04<\/td><td class=\"oth\">114.16<\/td><\/tr>\n<tr><td class=\"num\">2.<\/td><td class=\"cmpd\">AM2233<\/td><td class=\"oth\">2.44<\/td><td class=\"oth\">459.25<\/td><td class=\"oth\">112.2<\/td><td class=\"oth\">98.15<\/td><\/tr>\n<tr><td class=\"num\">3.<\/td><td class=\"cmpd\">JWH-200-d5<\/td><td class=\"oth\">2.47<\/td><td class=\"oth\">390.34<\/td><td class=\"oth\">155.07<\/td><td class=\"oth\">NA<\/td><\/tr>\n<tr><td class=\"num\">4.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for JWH-200\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/103610-04-4\/JWH-200\" target=\"_blank\" rel=\"noopener\">JWH-200<\/a><\/td><td class=\"oth\">2.48<\/td><td class=\"oth\">385.28<\/td><td class=\"oth\">155.07<\/td><td class=\"oth\">114.16<\/td><\/tr>\n<tr><td class=\"num\">5.<\/td><td class=\"cmpd\">WIN 55, 212<\/td><td class=\"oth\">3.34<\/td><td class=\"oth\">427.29<\/td><td class=\"oth\">155.07<\/td><td class=\"oth\">127.14<\/td><\/tr>\n<tr><td class=\"num\">6.<\/td><td class=\"cmpd\">JWH-073 N-butanoic acid<\/td><td class=\"oth\">3.39<\/td><td class=\"oth\">358.27<\/td><td class=\"oth\">155.08<\/td><td class=\"oth\">127.11<\/td><\/tr>\n<tr><td class=\"num\">7.<\/td><td class=\"cmpd\">JWH-073 4-hydroxybutyl<\/td><td class=\"oth\">3.4<\/td><td class=\"oth\">344.24<\/td><td class=\"oth\">155.09<\/td><td class=\"oth\">127.09<\/td><\/tr>\n<tr><td class=\"num\">8.<\/td><td class=\"cmpd\">JWH-018 N-pentanoic acid<\/td><td class=\"oth\">3.49<\/td><td class=\"oth\">372.18<\/td><td class=\"oth\">155.08<\/td><td class=\"oth\">127.14<\/td><\/tr>\n<tr><td class=\"num\">9.<\/td><td class=\"cmpd\">JWH-018 5-hydroxypentyl-d5<\/td><td class=\"oth\">3.54<\/td><td class=\"oth\">363.5<\/td><td class=\"oth\">155.08<\/td><td class=\"oth\">NA<\/td><\/tr>\n<tr><td class=\"num\">10.<\/td><td class=\"cmpd\">JWH-018 5-hydroxypentyl<\/td><td class=\"oth\">3.55<\/td><td class=\"oth\">358.27<\/td><td class=\"oth\">155.08<\/td><td class=\"oth\">127.11<\/td><\/tr>\n<tr><td class=\"num\">11.<\/td><td class=\"cmpd\">JWH-073 6-hydroxyindole<\/td><td class=\"oth\">3.77<\/td><td class=\"oth\">344.24<\/td><td class=\"oth\">155.09<\/td><td class=\"oth\">127.09<\/td><\/tr>\n<tr><td class=\"num\">12.<\/td><td class=\"cmpd\">JWH-073 5-hydroxyindole-d7<\/td><td class=\"oth\">3.81<\/td><td class=\"oth\">351.21<\/td><td class=\"oth\">155.07<\/td><td class=\"oth\">NA<\/td><\/tr>\n<tr><td class=\"num\">13.<\/td><td class=\"cmpd\">JWH-073 5-hydroxyindole<\/td><td class=\"oth\">3.83<\/td><td class=\"oth\">344.24<\/td><td class=\"oth\">155.09<\/td><td class=\"oth\">127.09<\/td><\/tr>\n<tr><td class=\"num\">14.<\/td><td class=\"cmpd\">JWH-073 7-hydroxyindole<\/td><td class=\"oth\">3.92<\/td><td class=\"oth\">344.24<\/td><td class=\"oth\">155.09<\/td><td class=\"oth\">127.09<\/td><\/tr>\n<tr><td class=\"num\">15.<\/td><td class=\"cmpd\">JWH-018 6-hydroxyindole<\/td><td class=\"oth\">3.94<\/td><td class=\"oth\">358.27<\/td><td class=\"oth\">155.08<\/td><td class=\"oth\">127.11<\/td><\/tr>\n<tr><td class=\"num\">16.<\/td><td class=\"cmpd\">JWH-018 5-hydroxyindole<\/td><td class=\"oth\">3.99<\/td><td class=\"oth\">358.27<\/td><td class=\"oth\">155.08<\/td><td class=\"oth\">127.11<\/td><\/tr>\n<tr><td class=\"num\">17.<\/td><td class=\"cmpd\">JWH-018 7-hydroxyindole<\/td><td class=\"oth\">4.08<\/td><td class=\"oth\">358.27<\/td><td class=\"oth\">155.08<\/td><td class=\"oth\">127.11<\/td><\/tr>\n<\/tbody><\/table>\n<table class=\"peaks col-lg-6 col-12 peak-50\"><thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> (min)<\/th><th style=\"text-align: center;width: 75px\">Precursor Ion<\/th><th style=\"text-align: center;width: 75px\">Quantifier Product Ion <\/th><th style=\"text-align: center;width: 75px\">Qualifier Product Ion<\/th><\/tr><\/thead><tbody>\n<tr><td class=\"num\">18.<\/td><td class=\"cmpd\">RCS-4<\/td><td class=\"oth\">4.15<\/td><td class=\"oth\">322.27<\/td><td class=\"oth\">135.12<\/td><td class=\"oth\">77.09<\/td><\/tr>\n<tr><td class=\"num\">19.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for XLR-11\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/1364933-54-9\/XLR-11\" target=\"_blank\" rel=\"noopener\">XLR-11<\/a><\/td><td class=\"oth\">4.21<\/td><td class=\"oth\">330.25<\/td><td class=\"oth\">232.17<\/td><td class=\"oth\">125.1<\/td><\/tr>\n<tr><td class=\"num\">20.<\/td><td class=\"cmpd\">JWH-015-d7<\/td><td class=\"oth\">4.27<\/td><td class=\"oth\">335.28<\/td><td class=\"oth\">155.07<\/td><td class=\"oth\">NA<\/td><\/tr>\n<tr><td class=\"num\">21.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for JWH-250\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/864445-43-2\/JWH-250\" target=\"_blank\" rel=\"noopener\">JWH-250<\/a><\/td><td class=\"oth\">4.27<\/td><td class=\"oth\">336.28<\/td><td class=\"oth\">121.12<\/td><td class=\"oth\">91.07<\/td><\/tr>\n<tr><td class=\"num\">22.<\/td><td class=\"cmpd\">JWH-015<\/td><td class=\"oth\">4.29<\/td><td class=\"oth\">328.26<\/td><td class=\"oth\">155.07<\/td><td class=\"oth\">127.13<\/td><\/tr>\n<tr><td class=\"num\">23.<\/td><td class=\"cmpd\">AM2201<\/td><td class=\"oth\">4.30<\/td><td class=\"oth\">360.26<\/td><td class=\"oth\">155.07<\/td><td class=\"oth\">127.14<\/td><\/tr>\n<tr><td class=\"num\">24.<\/td><td class=\"cmpd\">JWH-203<\/td><td class=\"oth\">4.39<\/td><td class=\"oth\">340.23<\/td><td class=\"oth\">188.18<\/td><td class=\"oth\">125.09<\/td><\/tr>\n<tr><td class=\"num\">25.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for JWH-073\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/208897-48-8\/JWH-073\" target=\"_blank\" rel=\"noopener\">JWH-073<\/a><\/td><td class=\"oth\">4.42<\/td><td class=\"oth\">328.26<\/td><td class=\"oth\">155.07<\/td><td class=\"oth\">127.13<\/td><\/tr>\n<tr><td class=\"num\">26.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for UR-144\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/1199943-44-6\/UR-144\" target=\"_blank\" rel=\"noopener\">UR-144<\/a><\/td><td class=\"oth\">4.44<\/td><td class=\"oth\">312.32<\/td><td class=\"oth\">214.17<\/td><td class=\"oth\">125.1<\/td><\/tr>\n<tr><td class=\"num\">27.<\/td><td class=\"cmpd\">JWH-073 4-hydroxyindole<\/td><td class=\"oth\">4.53<\/td><td class=\"oth\">344.24<\/td><td class=\"oth\">155.09<\/td><td class=\"oth\">127.09<\/td><\/tr>\n<tr><td class=\"num\">28.<\/td><td class=\"cmpd\">JWH-018-d9<\/td><td class=\"oth\">4.55<\/td><td class=\"oth\">351.34<\/td><td class=\"oth\">155.07<\/td><td class=\"oth\">NA<\/td><\/tr>\n<tr><td class=\"num\">29.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for JWH-018\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/209414-07-3\/JWH-018\" target=\"_blank\" rel=\"noopener\">JWH-018<\/a><\/td><td class=\"oth\">4.57<\/td><td class=\"oth\">342.27<\/td><td class=\"oth\">155.08<\/td><td class=\"oth\">127.11<\/td><\/tr>\n<tr><td class=\"num\">30.<\/td><td class=\"cmpd\">JWH-081<\/td><td class=\"oth\">4.64<\/td><td class=\"oth\">372.28<\/td><td class=\"oth\">185.12<\/td><td class=\"oth\">157.09<\/td><\/tr>\n<tr><td class=\"num\">31.<\/td><td class=\"cmpd\">JWH-018 4-hydroxyindole<\/td><td class=\"oth\">4.66<\/td><td class=\"oth\">358.27<\/td><td class=\"oth\">155.08<\/td><td class=\"oth\">127.11<\/td><\/tr>\n<tr><td class=\"num\">32.<\/td><td class=\"cmpd\">JWH-122<\/td><td class=\"oth\">4.69<\/td><td class=\"oth\">356.29<\/td><td class=\"oth\">169.12<\/td><td class=\"oth\">141.11<\/td><\/tr>\n<tr><td class=\"num\">33.<\/td><td class=\"cmpd\">JWH-019<\/td><td class=\"oth\">4.70<\/td><td class=\"oth\">356.29<\/td><td class=\"oth\">155.07<\/td><td class=\"oth\">127.1<\/td><\/tr>\n<tr><td class=\"num\">34.<\/td><td class=\"cmpd\">JWH-210<\/td><td class=\"oth\">4.84<\/td><td class=\"oth\">370.31<\/td><td class=\"oth\">183.12<\/td><td class=\"oth\">153.26<\/td><\/tr>\n<\/tbody><\/table><\/div><div class=\"chromatogram-conditions\"><h4>Conditions<\/h4><div class=\"conditions-container container-fluid\"><div class=\"row\"><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Column<\/th><td>Raptor Biphenyl  (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/9309A5E\" rel=\"noopener\">cat.# 9309A5E<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Dimensions:<\/th><td>50 mm x 3.0 mm ID<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Particle Size:<\/th><td>2.7 \u00b5m<\/td><\/tr><tr><td><\/td><tr><th class=\"sub conditions_header\" scope=\"row\">Guard Column:<\/th><td>Raptor Biphenyl EXP guard column cartridge 5.0 mm, 3.0 mm ID, 2.7 \u00b5m (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/9309A0253\" rel=\"noopener\">cat.# 9309A0253<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Temp.:<\/th><td>30 \u00b0C<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Standard\/Sample<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Conc.:<\/th><td>5 ng\/mL standard was prepared in urine and diluted 3x with 50:50 methanol:water<\/td><\/tr><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Vol.:<\/th><td>2 \u00b5L <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Mobile Phase<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">A:<\/th><td>0.1% Formic acid in water <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">B:<\/th><td>0.1% Formic acid in acetonitrile <\/td><\/tr><tr><td><\/td><td><table class=\"cgram_ramp\"><thead><tr><th>Time (min)<\/th><th>Flow (mL\/min)<\/th><th>%A<\/th><th>%B<\/th><\/tr><\/thead><tbody><tr><td>0.00<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><tr><td>1.00<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><tr><td>5.00<\/td><td>0.6<\/td><td>5<\/td><td>95<\/td><\/tr><tr><td>5.50<\/td><td>0.6<\/td><td>5<\/td><td>95<\/td><\/tr><tr><td>5.51<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><tr><td>7.00<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/table><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Detector<\/th><td>MS\/MS<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ion Mode:<\/th><td>ESI+ <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Mode:<\/th><td>MRM <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Instrument<\/th><td>UHPLC<\/td><\/tr><\/table><\/div><\/div><\/div><div class=\"chromatogram-related-skus\"><h4>Related SKUs<\/h4><ul><li>9309A0253<\/li><li>9309A5E<\/li><\/ul><\/div><div class=\"chromatogram-pdf-link\"><a href=\"https:\/\/ez.restek.com\/images\/cgram\/lc_cf0613.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"18\" height=\"18\" viewBox=\"0 0 18 18\"><g data-name=\"Group 2996\"><path data-name=\"Rectangle 1246\" d=\"M0 0h18v18H0z\" style=\"fill: none;\"><\/path><\/g><g data-name=\"Group 2997\"><path data-name=\"Path 729\" d=\"M13.412 11.4v2.017H5.345V11.4H4v2.017a1.349 1.349 0 0 0 1.345 1.345h8.068a1.349 1.349 0 0 0 1.345-1.345V11.4zm-.672-2.694-.948-.948-1.741 1.735V4H8.706v5.493L6.965 7.758l-.948.948 3.361 3.361z\" transform=\"translate(-.437 -.414)\" style=\"fill: rgb(13, 123, 196);\"><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u4e86\u786e\u5b9a\u662f\u5426\u53ef\u4ee5\u5728\u539f\u59cb\u65b9\u6cd5\u4e2d\u6dfb\u52a0\u65b0\u5f85\u6d4b\u7269\uff0c\u5728\u4e0e\u65e2\u5b9a\u65b9\u6cd5\u76f8\u540c\u7684\u6761\u4ef6\u4e0b\u5206\u6790\u4e86\u4e94\u79cd\u8865\u5145\u5408\u6210\u5927\u9ebb\u7d20\u548c\u4e39\u53c2\u7d20A\uff08\u4e00\u79cd\u7cbe\u795e\u836f\u7269\u841c\u7c7b\u5316\u5408\u7269\uff09\u3002\u8fd9\u4e9b\u65b0\u5174\u836f\u7269\u5728\u4eba\u5c3f\u4e2d\u4ee5 50 ng\/mL \u5236\u5907\u5e76\u7a00\u91ca\uff08\u5982\u56fe 3 \u6240\u793a\uff09\u3002Raptor \u8054\u82ef\u8272\u8c31\u67f1\u5177\u6709\u51fa\u8272\u7684\u4fdd\u7559\u80fd\u529b\uff0c\u53ef\u5c06\u76ee\u6807\u5316\u5408\u7269\u4e0e\u65e9\u671f\u6d17\u8131\u57fa\u8d28\u5e72\u6270\u5206\u79bb\u3002\u6b64\u5916\uff0c\u6240\u6709\u516d\u79cd\u65b0\u5174\u836f\u7269\u90fd\u5728\u68af\u5ea6\u5185\u5b8c\u6210\u6d17\u8131\uff0c\u5e76\u4e14\u5f7c\u6b64\u5206\u79bb\u826f\u597d\u3002\u539f\u59cb\u836f\u7269\u5217\u8868\u548c\u65b0\u5174\u836f\u7269\u5217\u8868\u7684\u53e0\u52a0\u8272\u8c31\u56fe\u8868\u660e\uff0c\u65b0\u836f\u7269\u5316\u5408\u7269\u53ef\u4ee5\u8f7b\u677e\u6dfb\u52a0\u5230\u73b0\u6709\u65b9\u6cd5\u4e2d\uff0c\u800c\u65e0\u9700\u66f4\u6362\u5206\u6790\u67f1\u3001\u8c03\u6574\u6d41\u52a8\u76f8\u6216\u68af\u5ea6\u6d17\u8131\u7a0b\u5e8f\uff08\u56fe4\uff09\u3002<\/p>\n\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\">\u56fe 3\uff1a\u7a00\u91ca\u4eba\u5c3f\u4e2d\u65b0\u5174\u836f\u7269\u5206\u6790<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<div class=\"wp-block-custom-chromatogram-article\"><div class=\"wp-block-custom-chromatogram-article\"><div class=\"chromatogram-image regular-image\"><img decoding=\"async\" src=\"https:\/\/ez.restek.com\/images\/cgram\/lc_cf0668.png\" alt=\"Emerging Drugs Poster Figure 3: Analysis of Emerging Drugs in Diluted Human Urine\" title=\"-\"><\/div><p class=\"article-id\" style=\"text-align:center\"> LC_CF0668<\/p><div class=\"chromatogram-peaks\"><h4>Peaks<\/h4><table class=\"peaks col-lg-6 col-12\">\n<thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> (min)<\/th><th style=\"text-align: center;width: 75px\">Precursor Ion<\/th><th style=\"text-align: center;width: 75px\">Product Ion<\/th><th style=\"text-align: center;width: 75px\">Product Ion<\/th><\/tr><\/thead>\n<tbody><tr><td class=\"num\">1.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for AB-FUBINACA\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/1185282-01-2\/AB-FUBINACA\" target=\"_blank\" rel=\"noopener\">AB-FUBINACA<\/a><\/td><td class=\"oth\">3.15<\/td><td class=\"oth\">369.0<\/td><td class=\"oth\">253.0<\/td><td class=\"oth\">109.1<\/td><\/tr>\n<tr><td class=\"num\">2.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for AB-PINACA\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/1445752-09-9\/AB-PINACA\" target=\"_blank\" rel=\"noopener\">AB-PINACA<\/a><\/td><td class=\"oth\">3.23<\/td><td class=\"oth\">331.2<\/td><td class=\"oth\">215.0<\/td><td class=\"oth\">286.1<\/td><\/tr>\n<tr><td class=\"num\">3.<\/td><td class=\"cmpd\">Salvinorin A<\/td><td class=\"oth\">3.39<\/td><td class=\"oth\">433.1<\/td><td class=\"oth\">373.0<\/td><td class=\"oth\">91.1<\/td><\/tr>\n<tr><td class=\"num\">4.<\/td><td class=\"cmpd\">5F-PB-22<\/td><td class=\"oth\">4.04<\/td><td class=\"oth\">377.2<\/td><td class=\"oth\">232.1<\/td><td class=\"oth\">143.9<\/td><\/tr>\n<tr><td class=\"num\">5.<\/td><td class=\"cmpd\">PB-22<\/td><td class=\"oth\">4.30<\/td><td class=\"oth\">359.2<\/td><td class=\"oth\">214.0<\/td><td class=\"oth\">144.0<\/td><\/tr>\n<tr><td class=\"num\">6.<\/td><td class=\"cmpd\">APINACA (AKB-48)<\/td><td class=\"oth\">4.76<\/td><td class=\"oth\">366.3<\/td><td class=\"oth\">135.1<\/td><td class=\"oth\">93.1<\/td><\/tr>\n<\/tbody><\/table><\/div><div class=\"chromatogram-conditions\"><h4>Conditions<\/h4><div class=\"conditions-container container-fluid\"><div class=\"row\"><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Column<\/th><td>Raptor Biphenyl  (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/9309A5E\" rel=\"noopener\">cat.# 9309A5E<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Dimensions:<\/th><td>50 mm x 3.0 mm ID<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Particle Size:<\/th><td>2.7 \u00b5m<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Pore Size:<\/th><td>90 \u00c5<\/td><\/tr><tr><td><\/td><tr><th class=\"sub conditions_header\" scope=\"row\">Guard Column:<\/th><td>Raptor Biphenyl EXP guard column cartridge 5 mm, 3 mm ID, 2.7 \u00b5m (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/9309A0253\" rel=\"noopener\">cat.# 9309A0253<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Temp.:<\/th><td>30 \u00b0C<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Standard\/Sample<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Conc.:<\/th><td>  50 ng\/mL in human urine and diluted 3x in a 0.2 \u03bcm PVDF Thomson SINGLE StEP filter vial with 50:50 water:methanol<\/td><\/tr><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Vol.:<\/th><td>2 \u00b5L <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Mobile Phase<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">A:<\/th><td>0.1% Formic acid in water <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">B:<\/th><td>0.1% Formic acid in acetonitrile <\/td><\/tr><tr><td><\/td><td><table class=\"cgram_ramp\"><thead><tr><th>Time (min)<\/th><th>Flow (mL\/min)<\/th><th>%A<\/th><th>%B<\/th><\/tr><\/thead><tbody><tr><td>0.00<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><tr><td>1.00<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><tr><td>5.00<\/td><td>0.6<\/td><td>5<\/td><td>95<\/td><\/tr><tr><td>5.50<\/td><td>0.6<\/td><td>5<\/td><td>95<\/td><\/tr><tr><td>5.51<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><tr><td>7.00<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Max Pressure:<\/th><td>400 bar<\/td><\/tr><\/table><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Detector<\/th><td>MS\/MS<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ion Mode:<\/th><td>ESI+ <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Mode:<\/th><td>Scheduled MRM <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Instrument<\/th><td>UHPLC<\/td><\/tr><\/table><\/div><\/div><\/div><div class=\"chromatogram-related-skus\"><h4>Related SKUs<\/h4><ul><li>9309A0253<\/li><li>9309A5E<\/li><\/ul><\/div><div class=\"chromatogram-related-searches\"><h4>Related Searches<\/h4><ul><li>Drugs<\/li><li>Emerging<\/li><li>cannabinoids<\/li><li>emerging drugs<\/li><li>metabolites<\/li><li>psychoactive<\/li><li>psychoactive drugs<\/li><li>spice<\/li><li>synthetic<\/li><li>synthetic cannabinoids<\/li><\/ul><\/div><div class=\"chromatogram-pdf-link\"><a href=\"https:\/\/ez.restek.com\/images\/cgram\/lc_cf0668.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"18\" height=\"18\" viewBox=\"0 0 18 18\"><g data-name=\"Group 2996\"><path data-name=\"Rectangle 1246\" d=\"M0 0h18v18H0z\" style=\"fill: none;\"><\/path><\/g><g data-name=\"Group 2997\"><path data-name=\"Path 729\" d=\"M13.412 11.4v2.017H5.345V11.4H4v2.017a1.349 1.349 0 0 0 1.345 1.345h8.068a1.349 1.349 0 0 0 1.345-1.345V11.4zm-.672-2.694-.948-.948-1.741 1.735V4H8.706v5.493L6.965 7.758l-.948.948 3.361 3.361z\" transform=\"translate(-.437 -.414)\" style=\"fill: rgb(13, 123, 196);\"><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\">\u56fe 3\uff1a\u7a00\u91ca\u5c3f\u6db2\u4e2d\u65b0\u5174\u836f\u7269\u4e0e\u5408\u6210\u5927\u9ebb\u7d20\u53ca\u4ee3\u8c22\u7269\u53e0\u52a0\u8272\u8c31\u56fe<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<div class=\"wp-block-custom-chromatogram-article\"><div class=\"wp-block-custom-chromatogram-article\"><div class=\"chromatogram-image regular-image\"><img decoding=\"async\" src=\"https:\/\/ez.restek.com\/images\/cgram\/lc_cf0669.png\" alt=\"Emerging Drugs Poster Figure 4: Overlay of Emerging Drugs Chromatogram and Synthetic Cannabinoids and Metabolites Chromatogram\" title=\"-\"><\/div><p class=\"article-id\" style=\"text-align:center\"> LC_CF0669<\/p><div class=\"chromatogram-peaks\"><h4>Peaks<\/h4><table class=\"peaks col-lg-6 col-12\">\n<thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> (min)<\/th><th style=\"text-align: center;width: 75px\">Precursor Ion<\/th><th style=\"text-align: center;width: 75px\">Product Ion<\/th><th style=\"text-align: center;width: 75px\">Product Ion<\/th><\/tr><\/thead>\n<tbody><tr><td class=\"num\">1.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for AB-FUBINACA\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/1185282-01-2\/AB-FUBINACA\" target=\"_blank\" rel=\"noopener\">AB-FUBINACA<\/a><\/td><td class=\"oth\">3.15<\/td><td class=\"oth\">369.0<\/td><td class=\"oth\">253.0<\/td><td class=\"oth\">109.1<\/td><\/tr>\n<tr><td class=\"num\">2.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for AB-PINACA\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/1445752-09-9\/AB-PINACA\" target=\"_blank\" rel=\"noopener\">AB-PINACA<\/a><\/td><td class=\"oth\">3.23<\/td><td class=\"oth\">331.2<\/td><td class=\"oth\">215.0<\/td><td class=\"oth\">286.1<\/td><\/tr>\n<tr><td class=\"num\">3.<\/td><td class=\"cmpd\">Salvinorin A<\/td><td class=\"oth\">3.39<\/td><td class=\"oth\">433.1<\/td><td class=\"oth\">373.0<\/td><td class=\"oth\">91.1<\/td><\/tr>\n<tr><td class=\"num\">4.<\/td><td class=\"cmpd\">5F-PB-22<\/td><td class=\"oth\">4.04<\/td><td class=\"oth\">377.2<\/td><td class=\"oth\">232.1<\/td><td class=\"oth\">143.9<\/td><\/tr>\n<tr><td class=\"num\">5.<\/td><td class=\"cmpd\">PB-22<\/td><td class=\"oth\">4.30<\/td><td class=\"oth\">359.2<\/td><td class=\"oth\">214.0<\/td><td class=\"oth\">144.0<\/td><\/tr>\n<tr><td class=\"num\">6.<\/td><td class=\"cmpd\">APINACA (AKB-48)<\/td><td class=\"oth\">4.76<\/td><td class=\"oth\">366.3<\/td><td class=\"oth\">135.1<\/td><td class=\"oth\">93.1<\/td><\/tr>\n<\/tbody><\/table><\/div><div class=\"chromatogram-conditions\"><h4>Conditions<\/h4><div class=\"conditions-container container-fluid\"><div class=\"row\"><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Column<\/th><td>Raptor Biphenyl  (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/9309A5E\" rel=\"noopener\">cat.# 9309A5E<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Dimensions:<\/th><td>50 mm x 3.0 mm ID<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Particle Size:<\/th><td>2.7 \u00b5m<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Pore Size:<\/th><td>90 \u00c5<\/td><\/tr><tr><td><\/td><tr><th class=\"sub conditions_header\" scope=\"row\">Guard Column:<\/th><td>Raptor Biphenyl EXP guard column cartridge 5 mm, 3 mm ID, 2.7 \u00b5m (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/9309A0253\" rel=\"noopener\">cat.# 9309A0253<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Temp.:<\/th><td>30 \u00b0C<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Standard\/Sample<\/th><td><\/td><\/tr><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Vol.:<\/th><td>2 \u00b5L <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Mobile Phase<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">A:<\/th><td>0.1% Formic acid in water <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">B:<\/th><td>0.1% Formic acid in acetonitrile <\/td><\/tr><tr><td><\/td><td><table class=\"cgram_ramp\"><thead><tr><th>Time (min)<\/th><th>Flow (mL\/min)<\/th><th>%A<\/th><th>%B<\/th><\/tr><\/thead><tbody><tr><td>0.00<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><tr><td>1.00<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><tr><td>5.00<\/td><td>0.6<\/td><td>5<\/td><td>95<\/td><\/tr><tr><td>5.50<\/td><td>0.6<\/td><td>5<\/td><td>95<\/td><\/tr><tr><td>5.51<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><tr><td>7.00<\/td><td>0.6<\/td><td>75<\/td><td>25<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Max Pressure:<\/th><td>400 bar<\/td><\/tr><\/table><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Detector<\/th><td>MS\/MS<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ion Mode:<\/th><td>ESI+ <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Mode:<\/th><td>Scheduled MRM <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Instrument<\/th><td>UHPLC<\/td><\/tr><\/table><\/div><\/div><\/div><div class=\"chromatogram-related-skus\"><h4>Related SKUs<\/h4><ul><li>9309A0253<\/li><li>9309A5E<\/li><\/ul><\/div><div class=\"chromatogram-related-searches\"><h4>Related Searches<\/h4><ul><li>Drugs<\/li><li>Emerging<\/li><li>cannabinoids<\/li><li>emerging drugs<\/li><li>metabolites<\/li><li>psychoactive<\/li><li>psychoactive drugs<\/li><li>spice<\/li><li>synthetic<\/li><li>synthetic cannabinoids<\/li><\/ul><\/div><div class=\"chromatogram-pdf-link\"><a href=\"https:\/\/ez.restek.com\/images\/cgram\/lc_cf0669.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"18\" height=\"18\" viewBox=\"0 0 18 18\"><g data-name=\"Group 2996\"><path data-name=\"Rectangle 1246\" d=\"M0 0h18v18H0z\" style=\"fill: none;\"><\/path><\/g><g data-name=\"Group 2997\"><path data-name=\"Path 729\" d=\"M13.412 11.4v2.017H5.345V11.4H4v2.017a1.349 1.349 0 0 0 1.345 1.345h8.068a1.349 1.349 0 0 0 1.345-1.345V11.4zm-.672-2.694-.948-.948-1.741 1.735V4H8.706v5.493L6.965 7.758l-.948.948 3.361 3.361z\" transform=\"translate(-.437 -.414)\" style=\"fill: rgb(13, 123, 196);\"><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u91cc\u4f7f\u7528\u7684\u65b9\u6cd5\uff0c\u53ef\u4ee5\u540c\u65f6\u5206\u6790\u65b0\u5174\u836f\u7269\u548c\u5408\u6210\u5927\u9ebb\u7d20\u5173\u952e\u5316\u5408\u7269\uff0c\u5305\u62ecJWH-018\u548cJWH-073\u53ca\u5176\u4ee3\u8c22\u7269\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff1a\u4ece\u7ed3\u679c\u53ef\u4ee5\u770b\u51fa\uff0c\u4e0e\u4f7f\u75285 \u03bcm\u5168\u591a\u5b54\u9897\u7c92\u8272\u8c31\u67f1\u76f8\u6bd4\uff08\u56fe5\u548c\u56fe6\uff09\uff0cRaptor Biphenyl \u6838\u58f3\u67f1\u6240\u7528\u5206\u6790\u65f6\u95f4\u66f4\u77ed\u3002\u4e5f\u5c31\u662f\u8bf4\uff1a\u4e0e\u4f20\u7edf\u7684\u5168\u591a\u5b54\u7845\u80f6\u9897\u7c92\u8272\u8c31\u67f1\u76f8\u6bd4\uff0c\u4f7f\u7528 Raptor Biphenyl \u6838\u58f3\u8272\u8c31\u67f1\u53ef\u5728\u66f4\u77ed\u7684\u65f6\u95f4\u5185\u66f4\u597d\u5730\u5206\u79bb\u66f4\u591a\u5316\u5408\u7269\uff08\u5305\u62ec\u5f02\u6784\u4f53\u548c\u65b0\u5174\u5316\u5408\u7269\uff09\uff0c\u4ece\u800c\u63d0\u9ad8\u5b9e\u9a8c\u5ba4\u6837\u54c1\u5206\u6790\u901a\u91cf\u3002<\/p>\n\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\">\u56fe 5: \u5728 Ultra Biphenyl \u8054\u82ef\u8272\u8c31\u67f1\uff08\u5168\u591a\u5b54\u7845\u80f6\u9897\u7c92\uff09\u4e0a\u5206\u6790\u5408\u6210\u5927\u9ebb\u7d20<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<div class=\"wp-block-custom-chromatogram-article\"><div class=\"wp-block-custom-chromatogram-article\"><div class=\"chromatogram-image wide-image\"><img decoding=\"async\" src=\"https:\/\/ez.restek.com\/images\/cgram\/lc_cf0526.png\" alt=\"Synthetic Cannabinoids on Ultra Biphenyl\" title=\"-\"><\/div><p class=\"article-id\" style=\"text-align:center\"> LC_CF0526<\/p><div class=\"chromatogram-peaks\"><h4>Peaks<\/h4><table class=\"peaks col-lg-6 col-12\">\n<thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> (min)<\/th><th style=\"text-align: center;width: 75px\">MRM1<\/th><th style=\"text-align: center;width: 75px\">MRM2<\/th><th style=\"text-align: center;width: 75px\">MRM3<\/th><\/tr><\/thead>\n<tbody><tr><td class=\"num\">1.<\/td><td class=\"cmpd\">WIN 48098<\/td><td class=\"oth\">3.85<\/td><td class=\"oth\">379.2\/135.2<\/td><td class=\"oth\">379.2\/114.3<\/td><td class=\"oth\">379.2\/107.3<\/td><\/tr>\n<tr><td class=\"num\">2.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for JWH-200\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/103610-04-4\/JWH-200\" target=\"_blank\" rel=\"noopener\">JWH-200<\/a><\/td><td class=\"oth\">4.34<\/td><td class=\"oth\">385.3\/114.0<\/td><td class=\"oth\">385.3\/127.0<\/td><td class=\"oth\">385.3\/155.0<\/td><\/tr>\n<tr><td class=\"num\">3.<\/td><td class=\"cmpd\">WIN 55212-2<\/td><td class=\"oth\">5.81<\/td><td class=\"oth\">427.2\/155.1<\/td><td class=\"oth\">427.2\/127.1<\/td><td class=\"oth\">427.2\/100.1<\/td><\/tr>\n<tr><td class=\"num\">4.<\/td><td class=\"cmpd\">AM-694<\/td><td class=\"oth\">7.01<\/td><td class=\"oth\">436.1\/309.1<\/td><td class=\"oth\">436.1\/231.2<\/td><td class=\"oth\">&#8212;<\/td><\/tr>\n<tr><td class=\"num\">5.<\/td><td class=\"cmpd\">JWH-015<\/td><td class=\"oth\">7.23<\/td><td class=\"oth\">328.3\/155.1<\/td><td class=\"oth\">328.3\/200.1<\/td><td class=\"oth\">328.3\/200.1<\/td><\/tr>\n<tr><td class=\"num\">6.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for JWH-250\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/864445-43-2\/JWH-250\" target=\"_blank\" rel=\"noopener\">JWH-250<\/a><\/td><td class=\"oth\">7.25<\/td><td class=\"oth\">336.3\/121.1<\/td><td class=\"oth\">336.3\/91.0<\/td><td class=\"oth\">336.3\/144.0<\/td><\/tr>\n<tr><td class=\"num\">7.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for JWH-073\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/208897-48-8\/JWH-073\" target=\"_blank\" rel=\"noopener\">JWH-073<\/a><\/td><td class=\"oth\">7.48<\/td><td class=\"oth\">328.2\/127.1<\/td><td class=\"oth\">328.2\/155.2<\/td><td class=\"oth\">328.2\/199.9<\/td><\/tr>\n<tr><td class=\"num\">8.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for JWH-018\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/209414-07-3\/JWH-018\" target=\"_blank\" rel=\"noopener\">JWH-018<\/a><\/td><td class=\"oth\">7.75<\/td><td class=\"oth\">342.3\/127.1<\/td><td class=\"oth\">342.3\/155.1<\/td><td class=\"oth\">342.3\/144.9<\/td><\/tr>\n<tr><td class=\"num\">9.<\/td><td class=\"cmpd\">JWH-081<\/td><td class=\"oth\">7.88<\/td><td class=\"oth\">372.2\/185.2<\/td><td class=\"oth\">372.2\/157.1<\/td><td class=\"oth\">372.2\/144.1<\/td><\/tr>\n<tr><td class=\"num\">10.<\/td><td class=\"cmpd\">JWH-019<\/td><td class=\"oth\">8.01<\/td><td class=\"oth\">356.3\/127.2<\/td><td class=\"oth\">356.3\/155.0<\/td><td class=\"oth\">356.3\/144.2<\/td><\/tr>\n<\/tbody><\/table><\/div><div class=\"chromatogram-conditions\"><h4>Conditions<\/h4><div class=\"conditions-container container-fluid\"><div class=\"row\"><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Column<\/th><td>Ultra Biphenyl  (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/9109552?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=LC_CF0526\" rel=\"noopener\">cat.# 9109552<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Dimensions:<\/th><td>50 mm x 2.1 mm ID<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Particle Size:<\/th><td>5 \u00b5m<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Pore Size:<\/th><td>100 \u00c5<\/td><\/tr><tr><td><\/td><tr><th class=\"sub conditions_header\" scope=\"row\">Temp.:<\/th><td>40 \u00b0C<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Standard\/Sample<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Diluent:<\/th><td>Methanol<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Conc.:<\/th><td>50 ng\/mL<\/td><\/tr><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Vol.:<\/th><td>5 \u00b5L <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Mobile Phase<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">A:<\/th><td>Water + 0.1% formic acid <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">B:<\/th><td>Acetonitrile + 0.1% formic acid <\/td><\/tr><tr><td><\/td><td><table class=\"cgram_ramp\"><thead><tr><th>Time (min)<\/th><th>Flow (mL\/min)<\/th><th>%A<\/th><th>%B<\/th><\/tr><\/thead><tbody><tr><td>0.00<\/td><td>0.5<\/td><td>95<\/td><td>5<\/td><\/tr><tr><td>10<\/td><td>0.5<\/td><td>5<\/td><td>95<\/td><\/tr><tr><td>10.1<\/td><td>0.5<\/td><td>95<\/td><td>5<\/td><\/tr><tr><td>12<\/td><td>stop<\/td><td><\/td><td><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/table><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Detector<\/th><td>AB SCIEX API 4000 MS\/MS<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Model #:<\/th><td>API 4000 <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ion Source:<\/th><td>TurboIonSpray<sup>&reg;<\/sup> <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ion Mode:<\/th><td>ESI+ <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ion Spray Voltage:<\/th><td>3000 kV<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Curtain Gas:<\/th><td>40  psi (275.8 kPa)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Gas 1:<\/th><td>40  psi (275.8 kPa)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Gas 2:<\/th><td>40  psi (275.8 kPa)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Source Temp.:<\/th><td>600 \u00b0C<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Mode:<\/th><td>MRM <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Dwell Time:<\/th><td>10 ms<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Instrument<\/th><td>Applied Biosystems\/MDS Sciex LC-MS\/MS System<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Acknowledgement<\/th><td>Special thanks to Paul Kennedy and Cayman Chemical for standards.<\/td><\/tr><\/table><\/div><\/div><\/div><div class=\"chromatogram-pdf-link\"><a href=\"https:\/\/ez.restek.com\/images\/cgram\/lc_cf0526.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"18\" height=\"18\" viewBox=\"0 0 18 18\"><g data-name=\"Group 2996\"><path data-name=\"Rectangle 1246\" d=\"M0 0h18v18H0z\" style=\"fill: none;\"><\/path><\/g><g data-name=\"Group 2997\"><path data-name=\"Path 729\" d=\"M13.412 11.4v2.017H5.345V11.4H4v2.017a1.349 1.349 0 0 0 1.345 1.345h8.068a1.349 1.349 0 0 0 1.345-1.345V11.4zm-.672-2.694-.948-.948-1.741 1.735V4H8.706v5.493L6.965 7.758l-.948.948 3.361 3.361z\" transform=\"translate(-.437 -.414)\" style=\"fill: rgb(13, 123, 196);\"><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\">\u56fe 6: \u5728 Ultra Biphenyl \u8054\u82ef\u8272\u8c31\u67f1\uff08\u5168\u591a\u5b54\u7845\u80f6\u9897\u7c92\uff09\u4e0a\u5206\u6790\u5408\u6210\u5927\u9ebb\u7d20\u4ee3\u8c22\u7269<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<div class=\"wp-block-custom-chromatogram-article\"><div class=\"wp-block-custom-chromatogram-article\"><div class=\"chromatogram-image wide-image\"><img decoding=\"async\" src=\"https:\/\/ez.restek.com\/images\/cgram\/lc_cf0531.png\" alt=\"Synthetic Cannabinoid Metabolites on Ultra Biphenyl (50 ng\/mL Extracted Urine Standard)\" title=\"-\"><\/div><p class=\"article-id\" style=\"text-align:center\"> LC_CF0531<\/p><div class=\"chromatogram-peaks\"><h4>Peaks<\/h4><table class=\"peaks col-lg-6 col-12 peak-50\">\n<thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> (min)<\/th><th style=\"text-align: center;width: 75px\">MRM1<\/th><th style=\"text-align: center;width: 75px\">MRM2<\/th><th style=\"text-align: center;width: 75px\">MRM3<\/th><\/tr><\/thead>\n<tbody><tr><td class=\"num\">1.<\/td><td class=\"cmpd\">JWH-073 4-hydroxybutyl<\/td><td class=\"oth\">2.05<\/td><td class=\"oth\">344.1\/155.1<\/td><td class=\"oth\">344.1\/127.2<\/td><td class=\"oth\">344.1\/144.0<\/td><\/tr>\n<tr><td class=\"num\">2.<\/td><td class=\"cmpd\">JWH-073 N-butanoic acid<\/td><td class=\"oth\">2.13<\/td><td class=\"oth\">358.1\/155.1<\/td><td class=\"oth\">358.1\/127.3<\/td><td class=\"oth\">358.1\/144.1<\/td><\/tr>\n<tr><td class=\"num\">3.<\/td><td class=\"cmpd\">JWH-018 N-pentanoic acid-d4 (IS)<\/td><td class=\"oth\">2.54<\/td><td class=\"oth\">376.1\/155.2<\/td><td class=\"oth\">376.1\/230.4<\/td><td class=\"oth\">376.1\/248.3<\/td><\/tr>\n<tr><td class=\"num\">4.<\/td><td class=\"cmpd\">JWH-018 N-pentanoic acid<\/td><td class=\"oth\">2.58<\/td><td class=\"oth\">372.1\/155.2<\/td><td class=\"oth\">372.1\/127.1<\/td><td class=\"oth\">372.1\/144.1<\/td><\/tr>\n<tr><td class=\"num\">5.<\/td><td class=\"cmpd\">JWH-018 5-hydroxypentyl<\/td><td class=\"oth\">2.58<\/td><td class=\"oth\">358.1\/155.2<\/td><td class=\"oth\">358.1\/127.1<\/td><td class=\"oth\">358.1\/230.3<\/td><\/tr>\n<tr><td class=\"num\">6.<\/td><td class=\"cmpd\">JWH-073 6-hydroxyindole<\/td><td class=\"oth\">3.52<\/td><td class=\"oth\">344.1\/155.2<\/td><td class=\"oth\">344.1\/127.1<\/td><td class=\"oth\">344.1\/145.1<\/td><\/tr>\n<tr><td class=\"num\">7.<\/td><td class=\"cmpd\">JWH-073 5-hydroxyindole<\/td><td class=\"oth\">3.68<\/td><td class=\"oth\">344.1\/155.2<\/td><td class=\"oth\">344.1\/127.1<\/td><td class=\"oth\">344.1\/160.0<\/td><\/tr>\n<\/tbody><\/table>\n<table class=\"peaks col-lg-6 col-12 peak-50\"><thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> (min)<\/th><th style=\"text-align: center;width: 75px\">MRM1<\/th><th style=\"text-align: center;width: 75px\">MRM2<\/th><th style=\"text-align: center;width: 75px\">MRM3<\/th><\/tr><\/thead><tbody>\n<tr><td class=\"num\">8.<\/td><td class=\"cmpd\">JWH-073 7-hydroxyindole<\/td><td class=\"oth\">3.95<\/td><td class=\"oth\">344.2\/155.1<\/td><td class=\"oth\">344.2\/127.1<\/td><td class=\"oth\">344.2\/216.3<\/td><\/tr>\n<tr><td class=\"num\">9.<\/td><td class=\"cmpd\">JWH-018 6-hydroxyindole<\/td><td class=\"oth\">4.00<\/td><td class=\"oth\">358.1\/155.1<\/td><td class=\"oth\">358.1\/127.2<\/td><td class=\"oth\">358.1\/145.2<\/td><\/tr>\n<tr><td class=\"num\">10.<\/td><td class=\"cmpd\">JWH-018 5-hydroxyindole<\/td><td class=\"oth\">4.12<\/td><td class=\"oth\">358.1\/155.1<\/td><td class=\"oth\">358.1\/127.2<\/td><td class=\"oth\">358.1\/160.2<\/td><\/tr>\n<tr><td class=\"num\">11.<\/td><td class=\"cmpd\">JWH-018 7-hydroxyindole<\/td><td class=\"oth\">4.34<\/td><td class=\"oth\">358.1\/155.1<\/td><td class=\"oth\">358.1\/127.1<\/td><td class=\"oth\">358.1\/230.3<\/td><\/tr>\n<tr><td class=\"num\">12.<\/td><td class=\"cmpd\">JWH-073 4-hydroxyindole-d7 (IS)<\/td><td class=\"oth\">5.10<\/td><td class=\"oth\">351.3\/127.0<\/td><td class=\"oth\">351.3\/223.0<\/td><td class=\"oth\">351.3\/155.0<\/td><\/tr>\n<tr><td class=\"num\">13.<\/td><td class=\"cmpd\">JWH-073 4-hydroxyindole<\/td><td class=\"oth\">5.14<\/td><td class=\"oth\">344.1\/155.2<\/td><td class=\"oth\">344.1\/127.2<\/td><td class=\"oth\">344.1\/160.0<\/td><\/tr>\n<tr><td class=\"num\">14.<\/td><td class=\"cmpd\">JWH-018 4-hydroxyindole<\/td><td class=\"oth\">5.44<\/td><td class=\"oth\">358.1\/155.2<\/td><td class=\"oth\">358.1\/230.2<\/td><td class=\"oth\">358.1\/127.1<\/td><\/tr>\n<\/tbody><\/table><\/div><div class=\"chromatogram-conditions\"><h4>Conditions<\/h4><div class=\"conditions-container container-fluid\"><div class=\"row\"><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Column<\/th><td>Ultra Biphenyl  (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/9109552\" rel=\"noopener\">cat.# 9109552<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Dimensions:<\/th><td>50 mm x 2.1 mm ID<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Particle Size:<\/th><td>5 \u00b5m<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Pore Size:<\/th><td>100 \u00c5<\/td><\/tr><tr><td><\/td><tr><th class=\"sub conditions_header\" scope=\"row\">Temp.:<\/th><td>25 \u00b0C<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Standard\/Sample<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Diluent:<\/th><td>50:50 Mobile phase<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Conc.:<\/th><td>50 ng\/mL extracted spiked sample<\/td><\/tr><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Vol.:<\/th><td>10 \u00b5L <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Mobile Phase<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">A:<\/th><td>Water + 0.05% acetic acid (pH approx. 3.4) <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">B:<\/th><td>Acetonitrile + 0.05% acetic acid <\/td><\/tr><tr><td><\/td><td><table class=\"cgram_ramp\"><thead><tr><th>Time (min)<\/th><th>Flow (mL\/min)<\/th><th>%A<\/th><th>%B<\/th><\/tr><\/thead><tbody><tr><td>0.00<\/td><td>0.5<\/td><td>55<\/td><td>45<\/td><\/tr><tr><td>2.00<\/td><td>0.5<\/td><td>55<\/td><td>45<\/td><\/tr><tr><td>6.00<\/td><td>0.5<\/td><td>15<\/td><td>85<\/td><\/tr><tr><td>6.10<\/td><td>0.5<\/td><td>5<\/td><td>95<\/td><\/tr><tr><td>7.00<\/td><td>0.5<\/td><td>5<\/td><td>95<\/td><\/tr><tr><td>7.10<\/td><td>0.5<\/td><td>55<\/td><td>45<\/td><\/tr><tr><td>8.50<\/td><td>stop<\/td><td><\/td><td><\/td><\/tr><\/tbody><\/table><\/td><\/tr><\/table><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Detector<\/th><td>API 4000<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Model #:<\/th><td>API 4000 <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ion Source:<\/th><td>TurboIonSpray<sup>&reg;<\/sup> <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ion Mode:<\/th><td>ESI+ <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ion Spray Voltage:<\/th><td>3 kV<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Curtain Gas:<\/th><td>40  psi (275.8 kPa)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Gas 1:<\/th><td>40  psi (275.8 kPa)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Gas 2:<\/th><td>40  psi (275.8 kPa)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Interface Temp.:<\/th><td>600 \u00b0C<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Mode:<\/th><td>MRM <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Dwell Time:<\/th><td>30 ms<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Instrument<\/th><td>API LC-MS\/MS<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Sample Preparation<\/th><td>1) Spike 1 mL blank urine sample with analytes and internal standards.<br \/><br \/>2) <i>Hydrolyze sample:<\/i><br \/>   &#8211; Add 1 mL solution of beta-glucuronidase from keyhole limpet (Sigma-Aldrich cat.# G8132). Solution is prepared at a concentration of 5000 Fishman units\/mL in 100 mM ammonium acetate buffer (pH = 5.0).<br \/>   &#8211; Incubate at 60 \u00b0C for 3 hours.<br \/><br \/><i>3) Extract sample on 6 mL, 500 mg C18 high-load end-capped Resprep SPE cartridge cat.# 24052<\/i>:<br \/>   &#8211; Add 1 mL 5 mM ammonium acetate + 0.1% acetic acid (pH = 4.2) to sample.<br \/>   &#8211; Condition cartridge with 3x 1 mL acetonitrile.<br \/>   &#8211; Condition cartridge with 3x 1 mL 5 mM ammonium acetate + 0.1% acetic acid.<br \/>   &#8211; Apply sample and allow to pass through under gravity.<br \/>   &#8211; Rinse with 3x 1 mL 5 mM ammonium acetate + 0.1% acetic acid.<br \/>   &#8211; Dry cartridge with vacuum for 10 minutes.<br \/>   &#8211; Elute with 3 mL acetonitrile followed by 3 mL butyl chloride.<br \/><br \/><i>4) Concentrate sample:<\/i><br \/>   &#8211; Evaporate sample to dryness under nitrogen at 40 \u00b0C.<br \/>   &#8211; Reconstitute in 0.5 mL water + 0.05% acetic acid:acetonitrile + 0.05% acetic acid (50:50).<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Notes<\/th><td>Resprep SPE cartridge cat.# 24052 was used to produce this chromatogram, but has since been discontinued. For assistance choosing a replacement for this application, contact Restek Technical Service or your local Restek representative.<br \/>&#8211; &#8211; &#8211; &#8211; &#8211; &#8211;<br \/>Since multiple transitions are shared between analytes, only 5 transitions are shown to simplify viewing. The transitions shown are: 344.1\/155.1 (blue trace), 358.1\/155.1 (green trace), 372.1\/155.2 (grey trace), 376.1\/155.2 (purple trace &#8211; internal standard), 351.3\/127.0 (red trace &#8211; internal standard).<br \/><br \/>CAD Gas was set to 4 psi.<br \/><br \/>For 1 ng\/mL calibration level, see chromatogram LC_CF0530.<br \/>For 500 ng\/mL calibration level, see chromatogram LC_CF0532.<br \/><\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Acknowledgement<\/th><td>Special thanks to Cayman Chemical for reference standards.<\/td><\/tr><\/table><\/div><\/div><\/div><div class=\"chromatogram-related-skus\"><h4>Related SKUs<\/h4><ul><li>9109552<\/li><\/ul><\/div><div class=\"chromatogram-pdf-link\"><a href=\"https:\/\/ez.restek.com\/images\/cgram\/lc_cf0531.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"18\" height=\"18\" viewBox=\"0 0 18 18\"><g data-name=\"Group 2996\"><path data-name=\"Rectangle 1246\" d=\"M0 0h18v18H0z\" style=\"fill: none;\"><\/path><\/g><g data-name=\"Group 2997\"><path data-name=\"Path 729\" d=\"M13.412 11.4v2.017H5.345V11.4H4v2.017a1.349 1.349 0 0 0 1.345 1.345h8.068a1.349 1.349 0 0 0 1.345-1.345V11.4zm-.672-2.694-.948-.948-1.741 1.735V4H8.706v5.493L6.965 7.758l-.948.948 3.361 3.361z\" transform=\"translate(-.437 -.414)\" style=\"fill: rgb(13, 123, 196);\"><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7ed3\u8bba<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u56e0\u9700\u8981\u5728\u5206\u6790\u6d4b\u8bd5\u670d\u52a1\u4e2d\u6dfb\u52a0\u65b0\u7684\u5316\u5408\u7269\uff0c\u9020\u6210\u5206\u6790\u5408\u6210\u5927\u9ebb\u7d20\u53ca\u5176\u4ee3\u8c22\u7269\u7684\u5b9e\u9a8c\u5ba4\u9762\u4e34\u7740\u8d8a\u6765\u8d8a\u5927\u7684\u538b\u529b\u3002\u867d\u7136\u53ef\u4ee5\u901a\u8fc7\u5f00\u53d1\u65b0\u65b9\u6cd5\u6765\u6ee1\u8db3\u8fd9\u4e00\u9700\u6c42\uff0c\u4f46\u5728\u73b0\u6709\u65b9\u6cd5\u4e2d\u6dfb\u52a0\u65b0\u7684\u5f85\u6d4b\u7269\u53ef\u4ee5\u8282\u7701\u65f6\u95f4\u548c\u8d44\u6e90\u3002\u5982\u4e0a\u6240\u793a\uff0c\u53ef\u4ee5\u770b\u5230Raptor Biphenyl\u8054\u82ef\u6838\u58f3\u67f1\u5728\u5206\u6790\u8be5\u7c7b\u7269\u8d28\u4e2d\u7684\u4f18\u52bf;\u7531\u4e8e\u8be5\u8272\u8c31\u67f1\u5177\u6709\u9ad8\u4fdd\u7559\u6027\u548c\u9009\u62e9\u6027\u7279\u6027\uff0c\u4ec5\u9700 5 \u5206\u949f\u5373\u53ef\u5206\u6790 35 \u79cd\u5f85\u6d4b\u7269\uff08\u5305\u62ec\u5f02\u6784\u4f53\u548c\u65b0\u5174\u5316\u5408\u7269\uff09\u3002<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n        <div class=\"cpb\">\n            <h3 class=\"cpb-heading\">\u76f8\u5173\u4ea7\u54c1<\/h3>\n            <hr class=\"cpb-heading-underline\" \/>\n            <div class=\"cpb-list\">\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/9309A5E\">                                \u8d27\u53f7\uff1a 9309A5E                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Raptor Biphenyl, 2.7 \u00b5m, 50 x 3.0 mm HPLC Column<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/9309A5E\">\u67e5\u770b\u4ea7\u54c1<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/9309A0253\">                                \u8d27\u53f7\uff1a 9309A0253                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Raptor Biphenyl EXP Guard Column Cartridge, 2.7 \u00b5m, 5 x 3.0 mm, 3-pk.<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/9309A0253\">\u67e5\u770b\u4ea7\u54c1<\/a>\n                                                    <\/div>\n                    <\/div>\n                            <\/div>\n        <\/div>\n        \n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6458\u8981 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