{"id":103502,"date":"2025-10-08T17:56:25","date_gmt":"2025-10-08T17:56:25","guid":{"rendered":"https:\/\/discover.restek.com\/?p=103502"},"modified":"2026-09-18T15:01:56","modified_gmt":"2026-09-18T15:01:56","slug":"epa-method-1634-for-6ppd-quinone-analysis","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/zh-hans\/application-notes-zh\/epa-method-1634-for-6ppd-quinone-analysis\/","title":{"rendered":"\u4f9d\u7167EPA 1634\u8981\u6c42\uff0c\u4f18\u53166PPD-\u918c\u5206\u6790\u65b9\u6cd5"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u6458\u8981<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">EPA 1634 \u8349\u6848\u4e3b\u8981\u7528\u4e8e\u6c34\u6027\u57fa\u8d28\uff08\u4e3b\u8981\u662f\u96e8\u6c34\u548c\u5730\u8868\u6c34\uff09\u4e2d6PPD-\u918c\u7684\u6d4b\u5b9a\uff0c\u662f\u57fa\u4e8e\u6027\u80fd\u7684\u4e00\u4e2aLC-MS\/MS\u65b9\u6cd5\u3002\u6211\u4eec\u4f18\u5316\u4e86\u5206\u6790\u67f1\u548c\u8272\u8c31\u6761\u4ef6\uff0c\u5728\u6ee1\u8db3EPA 1634\u65b9\u6cd5\u89c4\u8303\u7684\u540c\u65f6\uff0c\u63d0\u9ad8\u5206\u6790\u6548\u7387\uff0c\u603b\u8fd0\u884c\u65f6\u95f4\u4ece10min\u7f29\u77ed\u52305.5min\uff0c\u4e3a\u5b9e\u9a8c\u5ba4\u63d0\u4f9b\u4e86\u4e00\u79cd\u9ad8\u6548\u3001\u53ef\u9760\u7684\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5f15\u8a00<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">2023\u5e7412\u6708\u6839\u636e\u300a\u6e05\u6d01\u6c34\u6cd5\u6848\u300b\uff08CWA\uff09\uff0cEPA \u53d1\u5e03\u4e861634 \u8349\u6848\u65b9\u6cd5\uff0c\u4f7f\u7528\u6db2\u76f8\u8272\u8c31-\u4e32\u8054\u8d28\u8c31\u6cd5\uff08LC\/MS\/MS\uff09 \u6d4b\u5b9a\u6c34\u6027\u57fa\u8d28\u4e2d\u7684 6PPD-\u918c\uff0c\u4ee5\u5e94\u5bf96PPD-\u918c\u6e17\u5165\u5f84\u6d41\u6c34\u7684\u62c5\u5fe7\u30026PPD-\u918c\u662f\u8f6e\u80ce\u6297\u6c27\u5316\u52426-PPD\u7ecf\u81ed\u6c27\u6c27\u5316\u540e\u7684\u8f6c\u5316\u4ea7\u7269\uff0c\u5b83\u4f1a\u968f\u96e8\u6c34\u5f84\u6d41\u8fdb\u5165\u6c34\u751f\u751f\u6001\u7cfb\u7edf\uff0c\u4ece\u800c\u5bf9\u94f6\u9c91\u548c\u5176\u5b83\u5404\u79cd\u9c7c\u7c7b\u9020\u6210\u81f4\u547d\u4f24\u5bb3\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">EPA 1634 \u8349\u6848\u65b9\u6cd5\u662f\u4e00\u79cd\u57fa\u4e8e\u6027\u80fd\u7684\u65b9\u6cd5\uff0c\u8fd9\u610f\u5473\u7740\u5982\u679c\u7ed3\u679c\u88ab\u8bc1\u660e\u4e0e\u65e2\u5b9a\u65b9\u6cd5\u89c4\u8303\u7b49\u6548\uff0c\u5219\u53ef\u4ee5\u5bf9\u5176\u8fdb\u884c\u66f4\u6539\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u9664\u4f18\u5316\u4e86\u5206\u6790\u67f1\u548c LC-MS\/MS \u6761\u4ef6\u7f29\u77ed\u8fd0\u884c\u65f6\u95f4\u5916\uff0c\u5728\u6837\u54c1\u524d\u5904\u7406\u8fc7\u7a0b\u4e2d\u4f7f\u7528\u4e86\u6027\u80fd\u66f4\u9ad8\u7684 Resprep HLB SPE \u5c0f\u67f1\uff0c\u4ee5\u786e\u4fdd\u66f4\u597d\u7684\u63d0\u53d6\u6548\u679c\u3001\u8f83\u5c11\u57fa\u8d28\u5e72\u6270\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u5b9e\u9a8c<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u6807\u51c6\u54c1\u6eb6\u6db2<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u4e59\u8148\u4e3a\u6eb6\u5242\uff0c\u914d\u7f6e 7 \u4e2a\u4e0d\u540c\u6d53\u5ea6\uff08\u5177\u4f53\u89c1\u8868 I\uff09\u7684\u6807\u51c6\u54c1\u6eb6\u6db2\uff0c\u6839\u636e\u65b9\u6cd5\u9009\u62e9\u76f8\u5bf9\u6807\u51c6\u8bef\u5dee\uff08%RSE\uff09 \u6700\u5c0f\u7684\u62df\u5408\u66f2\u7ebf\u4f5c\u4e3a\u6821\u6b63\u66f2\u7ebf\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8868 I : \u6807\u51c6\u54c1\u6eb6\u6db2\u6d53\u5ea6<\/p>\n\n\n<figure class=\"wp-block-table\">\n<table>\n<tbody>\n<tr style=\"background-color: #008eaa;\">\n<td>\u00a0<\/td>\n<td style=\"color: #ffffff;\" colspan=\"7\"><strong>Calibration Standard Concentrations (ng\/mL)<\/strong><\/td>\n<\/tr>\n<tr style=\"background-color: #008eaa;\">\n<td style=\"color: #ffffff;\"><strong>Compound and Intermediate Standard Concentration<\/strong><\/td>\n<td style=\"color: #ffffff;\"><strong>C1<\/strong><\/td>\n<td style=\"color: #ffffff;\"><strong>C2<\/strong><\/td>\n<td style=\"color: #ffffff;\"><strong>C3<\/strong><\/td>\n<td style=\"color: #ffffff;\"><strong>C4<\/strong><\/td>\n<td style=\"color: #ffffff;\"><strong>C5<\/strong><\/td>\n<td style=\"color: #ffffff;\"><strong>C6<\/strong><\/td>\n<td style=\"color: #ffffff;\"><strong>C7<\/strong><\/td>\n<\/tr>\n<tr>\n<td>6PPD-quinone (20 ng\/mL)<\/td>\n<td>0.025<\/td>\n<td>0.050<\/td>\n<td>0.10<\/td>\n<td>0.50<\/td>\n<td>1.0<\/td>\n<td>5.0<\/td>\n<td>10.0<\/td>\n<\/tr>\n<tr>\n<td><sup>13<\/sup>C<sub>6<\/sub>-6PPD-quinone (20 ng\/mL)<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<\/tr>\n<tr>\n<td>D5-6PPD-quinone (20 ng\/mL)<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<td>1.0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n\n\n<h3 class=\"wp-block-heading\">QC \u6837\u54c1\u5236\u5907<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6839\u636eEPA 1634\u8349\u6848\u65b9\u6cd5\u7b2c7.2\u8282\uff0c\u7528\u4e8e\u7cbe\u5bc6\u5ea6\u3001\u51c6\u786e\u5ea6\u548c\u65b9\u6cd5\u68c0\u6d4b\u9650\u7684QC\u6837\u54c1\u7684\u5236\u5907\u65b9\u6cd5\uff1a\u5728\u805a\u4e19\u70ef\u74f6\u4e2d\u52a0\u5165250mL\u53bb\u79bb\u5b50\u6c34\u540e\u52a0\u516550\u03bcL\u63d0\u53d6\u548c\u975e\u63d0\u53d6\u5185\u6807\u7269\uff08EIS\/NIS\uff09\uff0c\u6807\u51c6\u54c1\u8d2d\u81ea\u5251\u6865\u540c\u4f4d\u7d20\u5b9e\u9a8c\u5ba4\uff08\u8d27\u53f7\u5206\u522b\u4e3a\uff1aCIL-ULM-12288-1.2\u3001CLM-12293-1.2 \u548c DLM-11616-1.2\uff09\u3002\u7528\u4e8e\u521d\u59cb\u7cbe\u5bc6\u5ea6\u548c\u56de\u6536\u7387\uff08IPR\uff09\u7684\u56db\u4e2a\u6837\u54c1\u52a0\u51656PPD-\u918c\u7684\u6d53\u5ea6\u4e3a40ng\/L\uff1b\u54116\u4efdMDL\u6837\u54c1\u4e2d\u52a0\u516550\u03bcL5\uff1a1\u7a00\u91ca\u7684\u5929\u7136\u6807\u51c6\u54c1\uff0c\u5f97\u5230\u9884\u63d0\u53d6\u6d53\u5ea6\u4e3a20ng\/mL\u7684\u6837\u54c1\u3002MDL\u6837\u54c1\u5728\u4e09\u5929\u5185\u5236\u5907\u3001\u63d0\u53d6\u548c\u5206\u6790\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6c34\u6837<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u771f\u5b9e\u6c34\u6837\u53d6\u81ea\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5dde\u5dde\u7acb\u5927\u5b66 322-\u4e1c\u9ad8\u901f\u516c\u8def\u65c1\u5f84\u6d41\u6c34\uff0c\u88c5\u5728 250mL \u7425\u73c0\u73bb\u7483\u74f6\u4e2d\uff0c\u76d6\u5b50\u5e26\u805a\u56db\u6c1f\u4e59\u70ef\u5185\u886c\u3002\u6837\u54c1\u5728\u4f4e\u4e8e\u6216\u7b49\u4e8e6\u00b0C\u7684\u6e29\u5ea6\u4e0b\u50a8\u5b58\u3002\u6240\u6709\u6837\u672c\u5747\u5728\u91c7\u96c6\u540e14\u5929\u5185\u63d0\u53d6\u3002\u5728\u6837\u54c1\u63d0\u53d6\u524d\u52a0\u5165EIS\uff0c\u63d0\u53d6\u540e\u52a0\u5165NIS\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6837\u54c1\u63d0\u53d6<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728Dionex AutoTrace 280 PFAS \u7cfb\u7edf\u4e0a\u4f7f\u7528 Resprep HLB SPE \u5c0f\u67f1 \uff086 mL\uff0c60 \u03bcm\uff0c200mg HLB \uff0c\u8d27\u53f7 #28264\uff09 \u8fdb\u884c\u6837\u54c1\u63d0\u53d6\u3002\u5177\u4f53\u63d0\u53d6\u6b65\u9aa4\u5982\u56fe 1\u6240\u793a\uff0c\u5728\u4e09\u5929\u5185\u63d0\u53d6\u5b8c\u6837\u54c1\u3002\u63d0\u53d6\u540e\u5411\u6837\u54c1\u4e2d\u52a0\u516550 \u03bcL \u672a\u63d0\u53d6\u5185\u6807\uff08NIS\u6765\u81ea\u5251\u6865\u540c\u4f4d\u7d20\u5b9e\u9a8c\u5ba4\uff0c\u8d27\u53f7DLM-11616-1.2\uff09\u3002<\/p>\n\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\">\u56fe 1: \u6837\u54c1\u5236\u5907\u6b65\u9aa4 (\u6b65\u9aa41-6\u6536\u96c6\u7684\u6eb6\u5242\u8bf7\u6536\u96c6\u5230\u5e9f\u6db2\u4e2d)<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<style>.kb-image103502_ddd3ea-f0 .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<div class=\"wp-block-kadence-image kb-image103502_ddd3ea-f0\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"755\" src=\"https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-01-1024x755.jpg\" alt=\"\" class=\"kb-img wp-image-19486\" title=\"-\" srcset=\"https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-01-1024x755.jpg 1024w, https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-01-300x221.jpg 300w, https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-01-768x567.jpg 768w, https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-01-1536x1133.jpg 1536w, https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-01.jpg 1800w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n<\/div><\/div><\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u4eea\u5668\u65b9\u6cd5<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u4f7f\u7528Waters ACQUITY Premier LC\u548cXevo TQ Absolute\u4e09\u91cd\u56db\u6781\u6746\u8d28\u8c31\u3002\u8868II \u7ed9\u51fa\u4e86 EPA 1634 \u8349\u6848\u65b9\u6cd5\u7684\u539f\u59cb\u6761\u4ef6\uff0c\u672c\u7814\u7a76\u5f00\u53d1\u7684\u4f18\u5316\u8272\u8c31\u67f1\u548c\u6761\u4ef6\u5982\u8868III \u6240\u793a\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8868 II: EPA 1634 \u65b9\u6cd5\u8349\u6848\u5efa\u8bae\u7684HPLC\u6761\u4ef6\uff08\u7b2c10.3.1\u8282\uff09<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>\u8272\u8c31\u67f1<\/td><td colspan=\"3\">C18 phase 4.6 x 100 mm, 3.5 \u00b5m<\/td><\/tr><tr><td>\u6d41\u52a8\u76f8 A<\/td><td colspan=\"3\">\u6c34\uff0c0.2%\u7532\u9178<\/td><\/tr><tr><td>\u6d41\u52a8\u76f8 B<\/td><td colspan=\"3\">\u4e59\u8148<\/td><\/tr><tr><td>\u67f1\u6e29<\/td><td colspan=\"3\">45 \u00b0C<\/td><\/tr><tr><td>\u8fdb\u6837\u91cf<\/td><td colspan=\"3\">20 \u00b5L<\/td><\/tr><tr><td>\u6d41\u901f<\/td><td colspan=\"3\">0.6 mL\/min<\/td><\/tr><tr><td>\u6700\u5927\u538b\u529b<\/td><td colspan=\"3\">7500 psi (517 bar)<\/td><\/tr><tr><td>\u68af\u5ea6<\/td><td>\u65f6\u95f4 (min)<\/td><td>%A<\/td><td>%B<\/td><\/tr><tr><td>&nbsp;<\/td><td>0<\/td><td>90<\/td><td>10<\/td><\/tr><tr><td>&nbsp;<\/td><td>1<\/td><td>90<\/td><td>10<\/td><\/tr><tr><td>&nbsp;<\/td><td>3<\/td><td>45<\/td><td>55<\/td><\/tr><tr><td>&nbsp;<\/td><td>6<\/td><td>1<\/td><td>99<\/td><\/tr><tr><td>&nbsp;<\/td><td>8<\/td><td>1<\/td><td>99<\/td><\/tr><tr><td>&nbsp;<\/td><td>8.5<\/td><td>90<\/td><td>10<\/td><\/tr><tr><td>&nbsp;<\/td><td>9<\/td><td>90<\/td><td>10<\/td><\/tr><tr><td>6PPD-\u918c\u9884\u671f\u6d17\u8131\u65f6\u95f4<\/td><td colspan=\"3\">7.53 min<\/td><\/tr><tr><td>\u603b\u8fd0\u884c\u65f6\u95f4<\/td><td colspan=\"3\">10.0 min<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">\u8868 III : \u4f18\u5316\u540e LC \u65b9\u6cd5\u6761\u4ef6<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>\u8272\u8c31\u67f1<\/td><td colspan=\"3\">Raptor C18 50 x 2.1 mm, 2.7 \u00b5m (\u8d27\u53f7 9304A52)<\/td><\/tr><tr><td>\u4fdd\u62a4\u4f4f<\/td><td colspan=\"3\">Raptor C18 EXP\u67f1\u5957\uff0825808\uff09\u548c\u67f1\u82af 5 x 2.1 mm, 2.7 \u00b5m (\u8d27\u53f7 9304A0252)<\/td><\/tr><tr><td>\u6d41\u52a8\u76f8 A<\/td><td colspan=\"3\">\u6c34\uff0c0.1% \u7532\u9178<\/td><\/tr><tr><td>\u6d41\u52a8\u76f8 B<\/td><td colspan=\"3\">\u4e59\u8148\uff0c0.1% \u7532\u9178<\/td><\/tr><tr><td>\u6eb6\u5242<\/td><td colspan=\"3\">\u4e59\u8148<\/td><\/tr><tr><td>\u67f1\u6e29<\/td><td colspan=\"3\">40 \u00b0C<\/td><\/tr><tr><td>\u8fdb\u6837\u91cf<\/td><td colspan=\"3\">3 \u00b5L<\/td><\/tr><tr><td>\u6d41\u901f<\/td><td colspan=\"3\">0.5 mL\/min<\/td><\/tr><tr><td>\u6700\u5927\u538b\u529b<\/td><td colspan=\"3\">3200 psi (220 bar)<\/td><\/tr><tr><td>\u68af\u5ea6<\/td><td>\u65f6\u95f4 (min)<\/td><td>%A<\/td><td>%B<\/td><\/tr><tr><td>&nbsp;<\/td><td>0<\/td><td>70<\/td><td>30<\/td><\/tr><tr><td>&nbsp;<\/td><td>3<\/td><td>0<\/td><td>100<\/td><\/tr><tr><td>&nbsp;<\/td><td>4<\/td><td>0<\/td><td>100<\/td><\/tr><tr><td>&nbsp;<\/td><td>4.01<\/td><td>70<\/td><td>30<\/td><\/tr><tr><td>&nbsp;<\/td><td>5.5<\/td><td>70<\/td><td>30<\/td><\/tr><tr><td>6PPD-\u918c\u9884\u671f\u6d17\u8131\u65f6\u95f4<\/td><td colspan=\"3\">1.93 min<\/td><\/tr><tr><td>\u603b\u8fd0\u884c\u65f6\u95f4<\/td><td colspan=\"3\">5.5 min<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u7ed3\u679c\u548c\u8ba8\u8bba<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">LC-MS\/MS\u65b9\u6cd5\u4f18\u5316\u53ca\u8272\u8c31\u6027\u80fd<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7531\u4e8eEPA 1634 \u8349\u6848\u65b9\u6cd5\u662f\u57fa\u4e8e\u6027\u80fd\u7684\uff0c\u56e0\u6b64\u53ea\u8981\u4ecd\u7136\u6ee1\u8db3\u65b9\u6cd5\u6027\u80fd\u8981\u6c42\uff0c\u5b9e\u9a8c\u5ba4\u53ef\u4ee5\u4fee\u6539\u67d0\u4e9b\u65b9\u6cd5\u6761\u4ef6\u3002\u5728\u672c\u7814\u7a76\u4e2d\uff0c\u6211\u4eec\u4f18\u5316\u4e86\u51e0\u4e2a\u53c2\u6570\uff0c\u4ee5\u7f29\u77ed\u8fd0\u884c\u65f6\u95f4\uff0c\u63d0\u9ad8\u5b9e\u9a8c\u5ba4\u901a\u91cf\uff0c\u5e76\u521b\u5efa\u4e86\u4e00\u79cd\u53ef\u7528\u4e8eHPLC\u548cUHPLC\u5e73\u53f0\u7684\u65b9\u6cd5\u3002\u6211\u4eec\u7684\u6700\u7ec8\u4f18\u5316\u65b9\u6cd5\u5982\u56fe2\u6240\u793a\uff0c\u5c066PPD-\u918c\u7684\u4fdd\u7559\u65f6\u95f4\u4ece 7.53min\u7f29\u77ed\u5230 1.93min\uff0c\u5c06\u603b\u8fd0\u884c\u65f6\u95f4\u4ece 10 min\u7f29\u77ed\u5230 5.5 min\uff0c\u6700\u5927\u80cc\u538b\u7ea6\u4e3a220 bar\u3002\u4e0b\u9762\u8be6\u7ec6\u8ba8\u8bba\u4e86\u6bcf\u4e2a\u53c2\u6570\u5177\u4f53\u4f18\u5316\u8fc7\u7a0b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">EPA 1634 \u8349\u6848\u65b9\u6cd5\u4f7f\u7528 C18 \u4f5c\u4e3a\u5206\u6790\u67f1\uff0c\u56e0\u6b64\u4f18\u5316\u65b9\u6cd5\u4e2d\u9009\u62e9\u7684\u8272\u8c31\u67f1\u4e3a Raptor C18\uff0cRaptor\u8272\u8c31\u67f1\u662f\u8868\u9762\u591a\u5b54\u9897\u7c92\uff08SPP\/\u6838\u58f3\u9897\u7c92\uff09\u8272\u8c31\u67f1\uff0c\u4e0e\u539f\u65b9\u6cd5\u4e2d3.5\u03bcm\u5168\u591a\u5b54\u9897\u7c92\u8272\u8c31\u67f1\u76f8\u6bd4\uff0c\u5b83\u5177\u6709\u6548\u7387\u9ad8\u3001\u8fd0\u884c\u65f6\u95f4\u77ed\u548c\u80cc\u538b\u4f4e\u7684\u7279\u70b9\u3002\u867d\u7136\u8349\u6848\u65b9\u6cd5\u4f7f\u7528\u7c92\u5f84\u4e3a 3.5\u03bcm\uff0c100 x 4.6 mm\uff0c\u4f46\u4e3a\u4e86\u63d0\u9ad8\u5206\u6790\u901f\u5ea6\uff0c\u4f18\u5316\u65b9\u6cd5\u65f6\u9009\u62e9\u7684\u8272\u8c31\u67f1\u4e3a2.7\u03bcm\uff0c50 x2.1 mm\u3002\u53e6\u5916\u5206\u6790\u67f1\u524d\u5b89\u88c5\u4e86Raptor C18 EXP\u4fdd\u62a4\u67f1\uff08\u8d27\u53f725808\u548c9304A0252\uff09\uff0c\u4ee5\u53bb\u9664\u9897\u7c92\u7269\u5ef6\u957f\u5206\u6790\u67f1\u4f7f\u7528\u5bff\u547d\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8f83\u5c0f\u5185\u5f84ID\u5206\u6790\u67f1\u5141\u8bb8\u66f4\u5feb\u7684\u8fd0\u884c\u65f6\u95f4\uff0c\u5e76\u4e14\u7531\u4e8e\u4f7f\u7528\u4e86\u8f83\u4f4e\u7684\u6d41\u901f\u4ece\u800c\u964d\u4f4e\u4e86\u80cc\u538b\u548c\u6eb6\u5242\u6d88\u8017\u91cf\u3002\u5c3d\u7ba1\u4f7f\u7528\u7a84\u5185\u5f84\u8272\u8c31\u67f1\u7f29\u77ed\u4e86\u8fd0\u884c\u65f6\u95f4\uff0c\u4f46\u65e9\u671f\u6d17\u8131\u57fa\u8d28\u4e0e\u76ee\u6807\u7269\u5206\u79bb\u826f\u597d\uff0c\u6b64\u5916\u4f7f\u7528Resprep HLB SPE\u5c0f\u67f1\u8fdb\u884c\u6837\u54c1\u5236\u5907\uff0c\u53ef\u4ee5\u83b7\u5f97\u975e\u5e38\u5e72\u51c0\u7684\u6837\u54c1\u63d0\u53d6\u7269\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u964d\u4f4e\u4e86\u57fa\u8d28\u5e72\u6270\u7684\u98ce\u9669\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u56e0\u4e3a\u9009\u62e9\u4e86\u8f83\u5c0f\u7684\u67f1\u5c3a\u5bf8\uff0c\u8fdb\u6837\u91cf\u4ece20\u03bcL\u51cf\u5c0f\u5230\u4e863\u03bcL\u3002\u51cf\u5c11\u8fdb\u6837\u91cf\u6709\u51e0\u4e2a\u597d\u5904\uff1a\u51cf\u5c11\u4e86\u5f15\u5165\u7684\u57fa\u8d28\u91cf\u53ef\u4ee5\u6539\u5584\u8272\u8c31\u5206\u79bb\uff0c\u5ef6\u957f\u67f1\u5bff\u547d\uff0c\u51cf\u5c11\u57fa\u8d28\u6548\u5e94\uff0c\u5b83\u8fd8\u4fdd\u5b58\u4e86\u6837\u672c\uff0c\u4ee5\u9632\u9700\u8981\u91cd\u65b0\u5206\u6790\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u65b9\u6cd5\u4f18\u5316\u8fc7\u7a0b\u4e2d\uff0c\u6211\u4eec\u6bd4\u8f83\u4e86\u7532\u9187\u548c\u4e59\u8148\uff08\u4e24\u8005\u5747\u542b0.1%\u7532\u9178\uff09\u4f5c\u4e3a\u6709\u673a\u76f8\u65f6\u7684\u5206\u79bb\u6548\u679c\uff0c\u4e24\u79cd\u6709\u673a\u76f8\u7684\u7ed3\u679c\u90fd\u662f\u53ef\u4ee5\u63a5\u53d7\u7684\uff1b\u6211\u4eec\u6700\u7ec8\u9009\u62e9\u4e59\u8148\u4f5c\u4e3a\u6709\u673a\u76f8\u662f\u56e0\u4e3a\u907f\u514d\u6837\u54c1\u7a00\u91ca\u5242\u548c\u8d77\u59cb\u6d41\u52a8\u76f8\u4e0d\u5339\u914d\uff0c\u4ee5\u6539\u5584\u5cf0\u5f62\u5e76\u63d0\u9ad8\u7075\u654f\u5ea6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u56e0\u4e3a\u4f7f\u7528\u8f83\u5c0f\u5185\u5f84\u8272\u8c31\u67f1\uff0c\u6d17\u8131\u68af\u5ea6\u4e5f\u4e0eEPA 1634\u8349\u6848\u65b9\u6cd5\u4e2d\u63cf\u8ff0\u7684\u6761\u4ef6\u4e0d\u540c\u3002\u4f18\u5316\u540e\u7684\u68af\u5ea6\u4e3a6PPD-\u918c\u63d0\u4f9b\u4e86\u5145\u5206\u7684\u4fdd\u7559\uff0c\u5e76\u907f\u514d\u4e86\u65e9\u671f\u6d17\u8131\u57fa\u8d28\u5bf9\u5f85\u6d4b\u7269\u7684\u5e72\u6270\u3002\u6d17\u81316PPD-\u918c\u540e\uff0c\u5728100%\u6709\u673a\u76f8B\u4e0b\u53c8\u8fd0\u884c\u4e863-4\u5206\u949f\uff0c\u4ee5\u51b2\u6d17\u67f1\u4e2d\u7684\u9ad8\u4fdd\u7559\u6c61\u67d3\u7269\uff0c\u7136\u540e\u6062\u590d\u5230\u8d77\u59cb\u6761\u4ef6\uff0c\u56e0\u6b64\u8272\u8c31\u67f1\u5728\u4e24\u6b21\u8fdb\u6837\u4e4b\u95f4\u8fdb\u884c\u4e86\u6709\u6548\u5730\u518d\u5e73\u8861\u3002\u6240\u5f00\u53d1\u7684\u65b9\u6cd5\u7684\u6700\u5927\u80cc\u538b220 bar\uff0c\u53ef\u7528\u4e8eHPLC\u548cUHPLC\u7cfb\u7edf\u3002<\/p>\n\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\">\u56fe 2: \u5728\u4f18\u5316\u7684 LC-MS\/MS \u6761\u4ef6\u4e0b\u5206\u6790\u5f84\u6d41\u6c34\u6837\u4e2d\u7684 6PPD-\u918c<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<div class=\"wp-block-custom-chromatogram-article\"><div class=\"wp-block-custom-chromatogram-article\"><div class=\"chromatogram-image regular-image\"><img decoding=\"async\" src=\"https:\/\/ez.restek.com\/images\/cgram\/lc_ev0600.png\" alt=\"6PPD-Quinone in Runoff Water on Raptor C18 by LC-MS\/MS\" title=\"-\"><\/div><p class=\"article-id\" style=\"text-align:center\"> LC_EV0600<\/p><div class=\"chromatogram-peaks\"><h4>Peaks<\/h4><table class=\"peaks col-12\">\n<thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> (min)<\/th><th style=\"text-align: center;width: 75px\">Conc.<br \/>(ng\/mL)<\/th><th style=\"text-align: center;width: 75px\">Precursor Ion<\/th><th style=\"text-align: center;width: 75px\">Product Ion 1<\/th><th style=\"text-align: center;width: 75px\">Product Ion 2<\/th><\/tr><\/thead>\n<tbody><tr><td class=\"num\">1.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 6PPD-Quinone (6PPD-Q)\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/2754428-18-5\/6PPD-Quinone\" target=\"_blank\" rel=\"noopener\">6PPD-Quinone (6PPD-Q)<\/a><\/td><td class=\"oth\">1.93<\/td><td class=\"oth\">2.8<\/td><td class=\"oth\">299.22<\/td><td class=\"oth\">215.07<\/td><td class=\"oth\">241.08<\/td><\/tr>\n<tr><td class=\"num\">2.<\/td><td class=\"cmpd\">6PPD-Quinone-D5 (6PPD-Q-D5)<\/td><td class=\"oth\">1.93<\/td><td class=\"oth\">1<\/td><td class=\"oth\">304.28<\/td><td class=\"oth\">220.08<\/td><td class=\"oth\">&#8211;<\/td><\/tr>\n<tr><td class=\"num\">3.<\/td><td class=\"cmpd\">6PPD-Quinone-<sup>13<\/sup>C<sub>6<\/sub> (6PPD-Q-<sup>13<\/sup>C<sub>6<\/sub>)<\/td><td class=\"oth\">1.93<\/td><td class=\"oth\">1<\/td><td class=\"oth\">305.28<\/td><td class=\"oth\">221.19<\/td><td class=\"oth\">&#8211;<\/td><\/tr>\n<\/tbody><\/table><div class=\"peaknotes\">The concentration listed is the final concentration following sample preparation.<\/div><\/div><div class=\"chromatogram-conditions\"><h4>Conditions<\/h4><div class=\"conditions-container container-fluid\"><div class=\"row\"><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Column<\/th><td>Raptor C18  (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/9304A52\" rel=\"noopener\">cat.# 9304A52<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Dimensions:<\/th><td>50 mm x 2.1 mm ID<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Particle Size:<\/th><td>2.7 \u00b5m<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Pore Size:<\/th><td>90 \u00c5<\/td><\/tr><tr><td><\/td><tr><th class=\"sub conditions_header\" scope=\"row\">Guard Column:<\/th><td>Raptor C18 EXP guard column cartridge 5 mm, 2.1 mm ID, 2.7 \u00b5m (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/9304A0252\" rel=\"noopener\">cat.# 9304A0252<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Temp.:<\/th><td>40 \u00b0C<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Standard\/Sample<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Diluent:<\/th><td>Acetonitrile<\/td><\/tr><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Vol.:<\/th><td>3 \u00b5L <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Mobile Phase<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">A:<\/th><td>0.1% Formic acid, water <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">B:<\/th><td>0.1% Formic acid, acetonitrile <\/td><\/tr><tr><td><\/td><td><table class=\"cgram_ramp\"><thead><tr><th>Time (min)<\/th><th>Flow (mL\/min)<\/th><th>%A<\/th><th>%B<\/th><\/tr><\/thead><tbody><tr><td>0.00<\/td><td>0.5<\/td><td>70<\/td><td>30<\/td><\/tr><tr><td>3.00<\/td><td>0.5<\/td><td>0<\/td><td>100<\/td><\/tr><tr><td>4.00<\/td><td>0.5<\/td><td>0<\/td><td>100<\/td><\/tr><tr><td>4.01<\/td><td>0.5<\/td><td>70<\/td><td>30<\/td><\/tr><tr><td>5.50<\/td><td>0.5<\/td><td>70<\/td><td>30<\/td><\/tr><\/tbody><\/table><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Max Pressure:<\/th><td>220 bar<\/td><\/tr><\/table><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Detector<\/th><td>Waters Xevo TQ-S<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ion Mode:<\/th><td>ESI+ <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Instrument<\/th><td>Waters ACQUITY Premier<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Sample Preparation<\/th><td>Runoff water was collected from roadway 322-East, located in State College, PA, U.S. One-half milliliter of an extracted internal standard (EIS) solution (20 ng\/mL of 6PPD-Q-<sup>13<\/sup>C<sub>6<\/sub>) was added to 250 mL of sample. Resprep Polymeric SPE cartridges, HLB (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/28264\" rel=\"noopener\">cat.# 28264<\/a>), and a Thermo AutoTrace PFAS instrument were used for the following sample preparation procedure (steps 1-6 were diverted to waste):<br \/>1. Wash each cartridge with 5 mL of acetonitrile.<br \/>2. Wash each cartridge with 5 mL of reagent water. <br \/>3. Add 5 mL of reagent water to each cartridge. <br \/>4. Add the sample to the SPE column (250 mL) at a flow rate of 10-15 mL\/min until the entire sample has been loaded onto the column. <br \/>5. Rinse the sample bottle with 5 mL of 50:50 methanol:reagent water (v\/v) and then pour onto the column reservoir.<br \/>6. Once the rinse has completely passed through the cartridge, dry the cartridge under nitrogen for at least 5 minutes. <br \/>7. Rinse the sample bottles with 5 mL of acetonitrile and collect the SPE eluent using 15 mL polypropylene tubes. Samples should be pulled through using a low vacuum such that the solvent exits the cartridge in a dropwise fashion. <br \/>8. Repeat step 7 with a second 4-5 mL aliquot of acetonitrile. The total volume collected should be ~9-10 mL. <br \/>9. Add 0.5 mL of the non-extracted internal standard (NIS) solution (20 ng\/mL of 6PPD-Q-D5) to the sample extract and vortex.<br \/>10. Transfer an aliquot of the sample to a screw-thread polypropylene autosampler vial (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/23243\" rel=\"noopener\">cat.# 23243<\/a>) and cap with a polypropylene screw-thread cap (<a class=\"ga-cgram-prod-link\" target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/24486\" rel=\"noopener\">cat.# 24486<\/a>).<\/td><\/tr><\/table><\/div><\/div><\/div><div class=\"chromatogram-related-skus\"><h4>Related SKUs<\/h4><ul><li>9304A0252<\/li><li>9304A52<\/li><li>28264<\/li><li>23243<\/li><li>24486<\/li><\/ul><\/div><div class=\"chromatogram-related-searches\"><h4>Related Searches<\/h4><ul><li>6PPD-quinone<\/li><li>6ppd-q<\/li><li>epa 1634<\/li><li>raptor c18<\/li><\/ul><\/div><div class=\"chromatogram-pdf-link\"><a href=\"https:\/\/ez.restek.com\/images\/cgram\/lc_ev0600.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"18\" height=\"18\" viewBox=\"0 0 18 18\"><g data-name=\"Group 2996\"><path data-name=\"Rectangle 1246\" d=\"M0 0h18v18H0z\" style=\"fill: none;\"><\/path><\/g><g data-name=\"Group 2997\"><path data-name=\"Path 729\" d=\"M13.412 11.4v2.017H5.345V11.4H4v2.017a1.349 1.349 0 0 0 1.345 1.345h8.068a1.349 1.349 0 0 0 1.345-1.345V11.4zm-.672-2.694-.948-.948-1.741 1.735V4H8.706v5.493L6.965 7.758l-.948.948 3.361 3.361z\" transform=\"translate(-.437 -.414)\" style=\"fill: rgb(13, 123, 196);\"><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u7ebf\u6027<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5982\u56fe3\u6240\u793a\uff0c\u4f18\u5316\u7684\u65b9\u6cd5\u57280.025-10 ng\/mL\u7684\u6821\u51c6\u8303\u56f4\u5185\u4ea7\u751f\u4e86\u826f\u597d\u7684\u7ebf\u6027\uff0cRSE=3.77%\uff0c\u5b8c\u5168\u5728&lt;20%\u7684\u65b9\u6cd5\u89c4\u8303\u8303\u56f4\u5185\u3002\u6b64\u5904\u8bc4\u4f30RSE\u800c\u4e0d\u662fr2\uff0c\u56e0\u4e3aEPA 1634\u8349\u6848\u65b9\u6cd5\u89c4\u5b9a\uff1a\u201c\u76f8\u5173\u7cfb\u6570r\u548c\u51b3\u5b9a\u7cfb\u6570r2\u4e0d\u518d\u88ab\u89c6\u4e3a\u7ebf\u6027\u7684\u9002\u5f53\u6307\u6807\uff0c\u4e0d\u5e94\u4e0e\u672c\u65b9\u6cd5\u7ed3\u5408\u4f7f\u7528[1]\u3002\u201d<\/p>\n\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\">\u56fe 3: \u6821\u51c6\u66f2\u7ebf\uff08\u4e8c\u6b21 1\/X \u62df\u5408\uff1b\u8fc7 0 \u70b9\uff09<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<style>.kb-image103502_68e0a9-dd .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<div class=\"wp-block-kadence-image kb-image103502_68e0a9-dd\"><figure class=\"aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"600\" src=\"https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-03-1024x600.jpg\" alt=\"\" class=\"kb-img wp-image-19492\" title=\"-\" srcset=\"https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-03-1024x600.jpg 1024w, https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-03-300x176.jpg 300w, https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-03-768x450.jpg 768w, https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-03-1536x900.jpg 1536w, https:\/\/discover.restek.com\/wp-content\/uploads\/figure-article-evan4446-03.jpg 1800w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><\/div>\n\n<\/div><\/div><\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">IPR<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u901a\u8fc7\u91cd\u590d\u8fdb\u6837\u5206\u6790\u56db\u4e2a40ng\/L\u7684\u52a0\u6807\u6837\u54c1\u6d4b\u5f97\u51c6\u786e\u6027\u548c\u7cbe\u786e\u6027\uff0c\u7ed3\u679c\u5982\u8868 IV \u6240\u793a\uff1a\u5e73\u5747\u56de\u6536\u7387\u4e3a95.00%\uff0cRSD\u4e3a4.00%\u3002EPA 1634 \u8349\u6848\u65b9\u6cd5\u89c4\u5b9a\u56de\u6536\u7387\u5fc5\u987b\u572870-130%\u8303\u56f4\u5185\uff0cRSD\u5fc5\u987b&lt;20%\uff0c\u56e0\u6b64\u8fd9\u4e9b\u7ed3\u679c\u5b8c\u5168\u5728\u65b9\u6cd5\u89c4\u683c\u8303\u56f4\u5185\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8868 IV: IPR \u6570\u636e (\u6d53\u5ea6\u4e3a40 ng\/L\u7684\u52a0\u6807\u6837\u54c1 [n = 4])<\/p>\n\n\n<figure class=\"wp-block-table\">\n<table style=\"border-color: #ced4d9;\">\n<tbody>\n<tr style=\"background-color: #008eaa; color: #ffffff;\">\n<td><strong>Sample #<\/strong><\/td>\n<td><strong>Recovery (ng\/L)<\/strong><\/td>\n<td><strong>Recovery (%)<\/strong><\/td>\n<\/tr>\n<tr>\n<td>1<\/td>\n<td>40.1<\/td>\n<td>100%<\/td>\n<\/tr>\n<tr>\n<td>2<\/td>\n<td>38.3<\/td>\n<td>95.80%<\/td>\n<\/tr>\n<tr>\n<td>3<\/td>\n<td>35.8<\/td>\n<td>89.50%<\/td>\n<\/tr>\n<tr>\n<td>4<\/td>\n<td>37.8<\/td>\n<td>94.50%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u65b9\u6cd5\u68c0\u6d4b\u9650\uff08MDL\uff09\u548c\u6700\u4f4e\u5b9a\u91cf\u6c34\u5e73\uff08ML\uff09<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u4e86\u5efa\u7acb MDL \u548c ML\uff0c\u6839\u636e\u8349\u6848\u65b9\u6cd5\u5728 3 \u5929\u5185\u63d0\u53d6\u4e86 6 \u4e2a\u91cd\u590d\u6837\u54c1\u3002\u5c06\u52a0\u6807\u548c\u7a7a\u767d\u7ed3\u679c\u7684\u6807\u51c6\u504f\u5dee\u4e58\u4ee5t\u503c3.143\uff0c\u9009\u62e9\u52a0\u6807\u548c\u7a7a\u767d\u4e4b\u95f4\u7ed3\u679c\u7684\u8f83\u9ad8\u8005\u4f5c\u4e3aMDL\u3002\u5728\u7b2c20.2\u8282\u4e2d\uff0cEPA 1634 \u8349\u6848\u65b9\u6cd5\u89c4\u5b9a\u201cML\u53ef\u4ee5\u901a\u8fc7\u5c06MDL\uff08\u5408\u5e76\u6216\u975e\u5408\u5e76, \u89c6\u60c5\u51b5\u800c\u5b9a\uff09\u4e58\u4ee53.18\u5e76\u5c06\u7ed3\u679c\u56db\u820d\u4e94\u5165\u5230\u6700\u63a5\u8fd11\u30012\u62165 x 10n\u7684\u6570\u5b57\u6765\u83b7\u5f97\uff0c\u5176\u4e2dn\u4e3a\u96f6\u6216\u6574\u6570[1]\u3002\u201c\u5728\u6211\u4eec\u7684\u7814\u7a76\u4e2d\uff0cMDL\uff08\u975e\u5408\u5e76\uff09\u4e3a0.285 ng\/L\uff0cML\u4e3a1 ng\/L\uff08\u8868V\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8868 V: \u53bb\u79bb\u5b50\u6c34\u4e2d 6-PPD-\u918c\u7684MDL\u548cML\u503c<\/p>\n\n\n<figure class=\"wp-block-table\">\n<table class=\"has-fixed-layout\" style=\"border-color: #ced4d9;\">\n<tbody>\n<tr style=\"background-color: #008eaa; color: #ffffff;\">\n<td><strong>MDL (ng\/L)<\/strong><\/td>\n<td><strong>ML (ng\/L)<\/strong><\/td>\n<\/tr>\n<tr>\n<td>0.285<\/td>\n<td>1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">EIS and NIS<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5982\u8868VI\u6240\u793a\uff0cEIS\u7684\u5e73\u5747\u56de\u6536\u7387\u4e3a82.2%\uff0cRSD\u4e3a5.6%\u3002\u5bf9\u4e8eNIS\uff0c\u5e73\u5747\u56de\u6536\u7387\u4e3a117.8%\uff0cRSD\u4e3a1.9%\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8868 VI: \u5185\u6807\u56de\u6536\u7387(n = 17)<\/p>\n\n\n<figure class=\"wp-block-table\">\n<table style=\"border-color: #ced4d9;\">\n<tbody>\n<tr style=\"background-color: #008eaa; color: #ffffff;\">\n<td><strong>Compound<\/strong><\/td>\n<td><strong>Avg. % Recovery<\/strong><\/td>\n<td><strong>%RSD<\/strong><\/td>\n<\/tr>\n<tr>\n<td>EIS<\/td>\n<td>82.2%<\/td>\n<td>5.6%<\/td>\n<\/tr>\n<tr>\n<td>NIS<\/td>\n<td>117.8%<\/td>\n<td>1.9%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">\u5f84\u6d41\u6c34<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u8868VII \u4e2d\u663e\u793a\u7684\u6570\u636e\u8868\u660e\uff0c\u5f3a\u5316\u53bb\u79bb\u5b50\u6c34\u548c\u5f84\u6d41\u6c34\u7684\u56de\u6536\u7387\u5728\u65b9\u6cd5\u89c4\u5b9a\u8303\u56f4\u5185\uff0870-130%\uff09\u3002\u6b64\u5916\uff0c\u4e0e\u672a\u5f3a\u5316\u7684\u53bb\u79bb\u5b50\u6c34\u76f8\u6bd4\uff0c\u672a\u5f3a\u5316\u7684\u5f84\u6d41\u6c34\u5bf9 6PPD \u918c\u7684\u53cd\u5e94\u9ad8\u51fa\u7ea6 30%\uff0c\u8868\u660e 6PPD-\u918c\u5b58\u5728\u4e8e\u6536\u96c6\u57fa\u8d28\u6837\u54c1\u7684\u4f4d\u7f6e\uff0c\u4f46\u6c34\u5e73\u4f4e\u4e8e\u5b9a\u91cf\u9650\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8868 VII: \u57fa\u8d28\u56de\u6536\u7387\uff0840 ng\/L\uff09<\/p>\n\n\n<figure class=\"wp-block-table\">\n<table style=\"border-color: #ced4d9;\">\n<tbody>\n<tr style=\"background-color: #008eaa; color: #ffffff;\">\n<td><strong>Matrix<\/strong><\/td>\n<td><strong>%Recovery<\/strong><\/td>\n<\/tr>\n<tr>\n<td>DI water<\/td>\n<td>100.70%<\/td>\n<\/tr>\n<tr>\n<td>Runoff water<\/td>\n<td>95.50%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u7ed3\u8bba<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">EPA 1634\u8349\u6848\u65b9\u6cd5\u6982\u8ff0\u4e86\u4f7f\u7528LC\/MS\/MS \u5206\u6790\u6c34\u6027\u57fa\u8d28\uff08\u4e3b\u8981\u662f\u96e8\u6c34\u548c\u5730\u8868\u6c34\uff09\u4e2d\u76846PPD-\u918c\u3002\u7531\u4e8e\u5b83\u662f\u4e00\u79cd\u57fa\u4e8e\u6027\u80fd\u7684\u65b9\u6cd5\uff0c\u56e0\u6b64\u53ea\u8981\u6ee1\u8db3\u65b9\u6cd5\u8981\u6c42\uff0c\u5c31\u53ef\u4ee5\u8fdb\u884c\u66f4\u6539\u3002\u672c\u7814\u7a76\u7684\u91cd\u70b9\u662f\u5f00\u53d1\u4e00\u79cd\u4f18\u5316\u7684LC-MS\/MS \u65b9\u6cd5\uff0c\u4ee5\u52a0\u5feb\u5206\u6790\u901f\u5ea6\u5e76\u63d0\u9ad8\u5b9e\u9a8c\u5ba4\u7684\u6837\u54c1\u901a\u91cf\u3002\u6839\u636eEPA 1634\u8349\u6848\u65b9\u6cd5\u4f7f\u7528Dionex AutoTrace 280 PFAS \u7cfb\u7edf\u8fdb\u884c\u6837\u54c1\u5236\u5907\u548c\u8403\u53d6\uff0c\u5e76\u91c7\u7528\u4f18\u5316\u7684 LCMS\/MS\u65b9\u6cd5\uff0c\u8be5\u7814\u7a76\u83b7\u5f97\u4e86\u4ee5\u4e0b\u7ed3\u679c\u3002\u6821\u51c6\u8303\u56f4\u4e3a0.025\u201310 ng\/mL\uff0c%RSE\u4e3a3.77%\u3002EIS\uff0813C6-PPD-\u918c\uff09\u7684\u5e73\u5747\u56de\u6536\u7387\u4e3a 82.2% \uff08n = 17\uff09\uff0cRSD \u4e3a 5.6%\uff0c\u800c NIS\uff08D5-6-PPD-\u918c\uff09\u7684\u5e73\u5747\u56de\u6536\u7387\u4e3a 117.8%\uff0cRSD \u4e3a 1.9%\u3002\u65b9\u6cd5\u68c0\u6d4b\u9650(MDL)\u4e3a0.285ng\/L\uff0c\u76f8\u5f53\u4e8eML \u4e3a 1 ng\/L\u3002\u5f53IPR \u52a0\u6807\u6d53\u5ea6\u4e3a 40 ng\/L \u65f6\uff0c\u5e73\u5747\u56de\u6536\u7387\u4e3a 95.0%\uff0cRSD \u4e3a 4.0%\u3002\u52a0\u6807\u6d53\u5ea6\u4e3a 40ng\/L \u7684\u57fa\u8d28\u6837\u54c1\u7684\u56de\u6536\u7387\u4e3a 95.5%\uff0c\u800c\u53bb\u79bb\u5b50\u6c34\u52a0\u6807\u7684\u56de\u6536\u7387\u4e3a 100.7%\u3002\u6240\u6709\u7ed3\u679c\u5747\u8fbe\u5230\u6216\u8d85\u8fc7\u8be5\u65b9\u6cd5\u7684\u89c4\u683c\u3002\u9664\u4e0a\u8ff0\u7ed3\u679c\u5916\uff0c\u4f18\u5316\u7684HPLC \u65b9\u6cd5\u8fd8\u80fd\u591f\u5c06\u603b\u8fd0\u884c\u65f6\u95f4\u4ece 10 min\u7f29\u77ed\u81f3 5.5 min\uff0c\u4ece\u800c\u5c06 6PPD-\u918c\u7684\u6d17\u8131\u65f6\u95f4\u4ece 7.5min\u7f29\u77ed\u81f3 1.9min\u3002\u4f18\u5316\u540e\u7684\u65b9\u6cd5\u8fd8\u51cf\u5c11\u4e86\u8fdb\u6837\u4f53\u79ef\u5e76\u4fdd\u6301\u4e86\u4f4e\u80cc\u538b\uff0c\u56e0\u6b64\u53ef\u4ee5\u5728HPLC \u548c UHPLC \u4eea\u5668\u4e0a\u8fd0\u884c\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u81f4\u8c22<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f5c\u8005\u611f\u8c22 Grayson Ritch\u3001Diego L\u00f3pez \u548c Colton Myers \u5bf9\u8fd9\u9879\u5de5\u4f5c\u7684\u8d21\u732e\u3002<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">\u53c2\u8003\u6587\u732e<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">1. &nbsp; &nbsp;U.S. Environmental Protection Agency, Draft Method 1634, Determination of 6PPD-quinone in aqueous matrices using liquid chromatography with tandem mass spectrometry (LC MS\/MS), December 2023.&nbsp;<a href=\"https:\/\/www.epa.gov\/system\/files\/documents\/2025-02\/draft-method-1634_1-24-24_508.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.epa.gov\/system\/files\/documents\/2025-02\/draft-method-1634_1-24-24_508.pdf<\/a><\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n        <div class=\"cpb\">\n            <h3 class=\"cpb-heading\">\u76f8\u5173\u4ea7\u54c1<\/h3>\n            <hr class=\"cpb-heading-underline\" \/>\n            <div class=\"cpb-list\">\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/9304A0252\">                                \u8d27\u53f7\uff1a 9304A0252                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Raptor C18 EXP Guard Column Cartridge, 2.7 \u00b5m, 5 x 2.1 mm, 3-pk.<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/9304A0252\">\u67e5\u770b\u4ea7\u54c1<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/9304A52\">                                \u8d27\u53f7\uff1a 9304A52                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Raptor C18, 2.7 \u00b5m, 50 x 2.1 mm HPLC Column<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/9304A52\">\u67e5\u770b\u4ea7\u54c1<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/28264\">                                \u8d27\u53f7\uff1a 28264                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Resprep Polymeric SPE Cartridge, HLB, 6 mL\/200 mg, 60 \u00b5m, 30-pk.<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/28264\">\u67e5\u770b\u4ea7\u54c1<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/25808\">                                \u8d27\u53f7\uff1a 25808                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">EXP Direct Connect Holder for EXP Guard Cartridges, Includes Fitting &amp; Ferrules<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/25808\">\u67e5\u770b\u4ea7\u54c1<\/a>\n                                                    <\/div>\n                    <\/div>\n                            <\/div>\n        <\/div>\n        \n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u6458\u8981 EPA 1634 \u8349\u6848\u4e3b\u8981\u7528\u4e8e\u6c34\u6027\u57fa\u8d28\uff08\u4e3b\u8981\u662f\u96e8\u6c34\u548c\u5730\u8868\u6c34\uff09\u4e2d6PPD-\u918c\u7684\u6d4b\u5b9a\uff0c\u662f\u57fa\u4e8e\u6027\u80fd\u7684\u4e00\u4e2aLC-MS\/MS\u65b9\u6cd5\u3002\u6211\u4eec\u4f18\u5316\u4e86\u5206\u6790\u67f1\u548c\u8272\u8c31\u6761\u4ef6\uff0c\u5728\u6ee1\u8db3EPA 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6PPD-\u918c\uff0c\u4ee5\u5e94\u5bf96PPD-\u918c\u6e17\u5165\u5f84\u6d41\u6c34\u7684\u62c5\u5fe7\u30026PPD-\u918c\u662f\u8f6e\u80ce\u6297\u6c27\u5316\u52426-PPD\u7ecf\u81ed\u6c27\u6c27\u5316\u540e\u7684\u8f6c\u5316\u4ea7\u7269\uff0c\u5b83\u4f1a\u968f\u96e8\u6c34\u5f84\u6d41\u8fdb\u5165\u6c34\u751f\u751f\u6001\u7cfb\u7edf\uff0c\u4ece\u800c\u5bf9\u94f6\u9c91\u548c\u5176\u5b83\u5404\u79cd\u9c7c\u7c7b\u9020\u6210\u81f4\u547d\u4f24\u5bb3\u3002 EPA 1634 \u8349\u6848\u65b9\u6cd5\u662f\u4e00\u79cd\u57fa\u4e8e\u6027\u80fd\u7684\u65b9\u6cd5\uff0c\u8fd9\u610f\u5473\u7740\u5982\u679c\u7ed3\u679c\u88ab\u8bc1\u660e\u4e0e\u65e2\u5b9a\u65b9\u6cd5\u89c4\u8303\u7b49\u6548\uff0c\u5219\u53ef\u4ee5\u5bf9\u5176\u8fdb\u884c\u66f4\u6539\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u9664\u4f18\u5316\u4e86\u5206\u6790\u67f1\u548c LC-MS\/MS \u6761\u4ef6\u7f29\u77ed\u8fd0\u884c\u65f6\u95f4\u5916\uff0c\u5728\u6837\u54c1\u524d\u5904\u7406\u8fc7\u7a0b\u4e2d\u4f7f\u7528\u4e86\u6027\u80fd\u66f4\u9ad8\u7684 Resprep HLB SPE \u5c0f\u67f1\uff0c\u4ee5\u786e\u4fdd\u66f4\u597d\u7684\u63d0\u53d6\u6548\u679c\u3001\u8f83\u5c11\u57fa\u8d28\u5e72\u6270\u3002 \u5b9e\u9a8c \u6807\u51c6\u54c1\u6eb6\u6db2 \u4ee5\u4e59\u8148\u4e3a\u6eb6\u5242\uff0c\u914d\u7f6e 7 \u4e2a\u4e0d\u540c\u6d53\u5ea6\uff08\u5177\u4f53\u89c1\u8868 I\uff09\u7684\u6807\u51c6\u54c1\u6eb6\u6db2\uff0c\u6839\u636e\u65b9\u6cd5\u9009\u62e9\u76f8\u5bf9\u6807\u51c6\u8bef\u5dee\uff08%RSE\uff09 \u6700\u5c0f\u7684\u62df\u5408\u66f2\u7ebf\u4f5c\u4e3a\u6821\u6b63\u66f2\u7ebf\u3002 \u8868 I : \u6807\u51c6\u54c1\u6eb6\u6db2\u6d53\u5ea6 \u00a0 Calibration Standard Concentrations (ng\/mL) Compound and Intermediate Standard Concentration C1 C2 C3 C4 C5 C6 C7 6PPD-quinone (20 ng\/mL) 0.025 0.050 0.10 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