{"id":39981,"date":"2021-10-15T00:00:00","date_gmt":"2021-10-15T00:00:00","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/sample-preparation-product-guide-find-effective-solutions-fast\/"},"modified":"2026-02-03T20:22:16","modified_gmt":"2026-02-03T20:22:16","slug":"sample-preparation-product-guide-find-effective-solutions-fast","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/zh-hans\/articles-zh\/gnar3729\/sample-preparation-product-guide-find-effective-solutions-fast","title":{"rendered":"Sample Preparation Product Guide: Find Effective Solutions Fast"},"content":{"rendered":"\n

At Restek, we believe that the foundation for separation is preparation. A perfect chromatographic method can still be compromised by a sample preparation approach that does not properly match the sample. The matrix that the analytes of interest are in can present real problems, but overdoing sample preparation procedures can introduce other issues. The key is striking a balance so that you get the sample just clean or concentrated enough to successfully perform your work between scheduled maintenance events without investing more time and money into the sample preparation process than is necessary\u2013or worse yet, losing analytes during the sample prep process and affecting the accuracy of the results!<\/p>\n\n\n\n

Knowing how important sample preparation is to chromatographic analyses, Restek offers a wide variety of sample preparation products to make sure that your sample is ready to be separated, identified, and quantified successfully. This sample preparation product guide will explain the basics of each technique and help you quickly identify the best one for your sample matrix.<\/p>\n\n\n\n

<\/a>Table of Contents<\/h2>\n\n\n\n
    \n
  1. Solid Phase Extraction (SPE)<\/a>\n
      \n
    1. Picking an SPE Sorbent (the Stationary Phase)<\/a>\n
        \n
      1. Primarily Reversed-Phase Sorbents<\/a>\n
          \n
        1. C8 and C18 Bonded Phases<\/a><\/li>\n\n\n\n
        2. Styrene-divinylbenzene (SDVB)<\/a><\/li>\n<\/ol>\n<\/li>\n\n\n\n
        3. Primarily Normal Phase Sorbents<\/a>\n
            \n
          1. Unbonded Silica Phases<\/a><\/li>\n\n\n\n
          2. Alumina<\/a><\/li>\n\n\n\n
          3. Florisil<\/a><\/li>\n<\/ol>\n<\/li>\n\n\n\n
          4. Multi-Functional Sorbents<\/a>\n
              \n
            1. Diol<\/a><\/li>\n\n\n\n
            2. Amino (NH2<\/sub>)<\/a><\/li>\n\n\n\n
            3. Primary\/Secondary Amine (PSA)<\/a><\/li>\n\n\n\n
            4. Carbon Based<\/a><\/li>\n<\/ol>\n<\/li>\n\n\n\n
            5. Ion-Exchange Sorbents<\/a>\n
                \n
              1. Anion Exchange<\/a><\/li>\n\n\n\n
              2. Cation Exchange<\/a><\/li>\n\n\n\n
              3. Weak Ion Exchange<\/a><\/li>\n\n\n\n
              4. Strong Ion Exchange<\/a><\/li>\n<\/ol>\n<\/li>\n\n\n\n
              5. Method Specific Products<\/a><\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n\n\n\n
              6. QuEChERS<\/a>\n
                  \n
                1. Extraction Salt Selection<\/a><\/li>\n\n\n\n
                2. dSPE Cleanup Products<\/a><\/li>\n<\/ol>\n<\/li>\n\n\n\n
                3. Supported Liquid Extraction (SLE)<\/a><\/li>\n\n\n\n
                4. Sample Filtration<\/a><\/li>\n\n\n\n
                5. Solid Phase Microextraction (SPME)<\/a><\/li>\n\n\n\n
                6. Accelerated Solvent Extraction (ASE)<\/a><\/li>\n\n\n\n
                7. In-Line Sample Preparation<\/a><\/li>\n\n\n\n
                8. Vials and Well Plates<\/a>\n
                    \n
                  1. Vials<\/a><\/li>\n\n\n\n
                  2. Well Plates<\/a><\/li>\n<\/ol>\n<\/li>\n\n\n\n
                  3. Syringes<\/a><\/li>\n<\/ol>\n\n\n\n

                    In addition to this article, our Sample Preparation FAQs<\/a> cover additional information about the products discussed here.<\/p>\n\n\n\n

                    <\/a>Solid Phase Extraction (SPE)<\/h2>\n\n\n\n

                    \"figure-article-GNAR3729-01.jpg\"<\/figure><\/h2>\n\n\n\n

                    SPE is a common sample preparation technique used to clean up and\/or concentrate samples prior to GC or LC separation and detection. Even though SPE is a step before<\/em> the analytical chromatography, it\u2019s helpful to remember that SPE basically is<\/em> chromatography. The principles that separate compounds in an analytical GC or LC column are the same ones that will separate unwanted matrix components from analytes of interest prior to analysis using an SPE product. Keeping this in mind will help you navigate the wide variety of SPE products that are available.<\/p>\n\n\n\n

                    <\/a>Picking an SPE Sorbent (the Stationary Phase)<\/em><\/h3>\n\n\n\n

                    With your sample in mind, select an SPE sorbent with characteristics that will be successful at separating the matrix from your analytes. To best do that, it\u2019s helpful to know certain properties of your analytes and the matrix they are in. Are the target compounds polar or nonpolar? Are they (or can they be) in a charged state? Are they strong or weak organic acids or bases? Are they planar? The answer to each of those questions will help direct you to a family of products that is covered in this sample preparation product guide. Below is a brief description of the types of SPE products divided into broad separation mechanism categories.<\/p>\n\n\n\n