{"id":43728,"date":"2025-10-03T21:35:58","date_gmt":"2025-10-03T21:35:58","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/fast-analysis-of-mcpds-by-lpgc-ms\/"},"modified":"2026-01-03T18:37:14","modified_gmt":"2026-01-03T18:37:14","slug":"fast-analysis-of-mcpds-by-lpgc-ms","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/zh-hans\/articles-fr\/gnfa4239\/fast-analysis-of-mcpds-by-lpgc-ms","title":{"rendered":"Fast Analysis of MCPDs by LPGC-MS"},"content":{"rendered":"\n<ul class=\"wp-block-list\">\n<li>2x faster than conventional GC-MS analysis.<\/li>\n\n\n\n<li>Reduces helium usage by 69% compared to conventional GC-MS methods.&nbsp;<\/li>\n\n\n\n<li>Rxi-17Sil MS kits are factory connected with a proven leak-free connector making LPGC as simple as a column change.<\/li>\n<\/ul>\n\n\n\n<p>MCPDs are impurities found in food products that result from heat processes in manufacturing. They have been largely detected in refined oils, including vegetable oil and palm oil, along with processed foods that use these oils in their formulations, including baby formula. MCPDs are typically analyzed by GC-MS using a 30 m x 0.25 mm ID x 0.25 \u03bcm capillary column with a 5% diphenyl, 95% dimethyl polysiloxane or a 50% diphenyl, 50% dimethyl polysiloxane stationary phase. Run times using conventional GC-MS are typically over 12 minutes. With the large volumes of samples laboratories need to process, there is a motivation to cut down on run times, both to increase sample throughput and save on helium costs. However, techniques to shorten analysis times often compromise critical isomer separations.<\/p>\n\n\n\n<p>Low-pressure gas chromatography (LPGC) offers a unique solution: by lowering the pressure inside the GC column, analysis times and helium usage are significantly reduced, allowing laboratories to analyze more samples at a lower production cost. Utilizing our LPGC Rxi-17Sil MS kit (cat.# 11805), analysis time was cut in half, and helium consumption was reduced by 69% compared to conventional GC-MS methods. Additionally, good resolution was achieved for the critical separation of 2-MCPD and 3-MCPD, and these analytes were both resolved well before the derivatization agent. LPGC is as easy as a column change and offers a significant benefit by reducing analysis time, allowing for increased sample throughput while also conserving helium. Each factory-coupled LPGC kit is individually tested to ensure a leak-free connection. To learn more about the LPGC technique, visit <a href=\"https:\/\/www.restek.com\/articles\/an-introduction-to-low-pressure-GC-MS-LPGC-MS\" target=\"_blank\" rel=\"noopener\">www.restek.com\/lpgc<\/a><\/p>\n\n\n<div class=\"wp-block-custom-chromatogram-article-top\"><div class=\"chromatogram-article-placeholder\"><div class=\"figure-heading\"><strong>Figure 1:\u00a0<\/strong>MCPDs on LPGC Rxi-17Sil MS Compared to Conventional GC-MS.<\/div><div class='chromatogram-article-inner-full'><div class=\"chromatogram-article-inner\">\n<div class=\"wp-block-custom-chromatogram-article\"><div class=\"wp-block-custom-chromatogram-article\"><div class=\"chromatogram-image wide-image\"><img decoding=\"async\" src=\"https:\/\/ez.restek.com\/images\/cgram\/gc_fs0595.png\" alt=\"Comparison of Conventional and LPGC Analysis of 2-MCPD and 3-MCPD\" title=\"-\"><\/div><p class=\"article-id\" style=\"text-align:center\"> GC_FS0595<\/p><div class=\"chromatogram-peaks\"><h4>Peaks<\/h4><table class=\"peaks col-lg-6 col-12\">\n<thead><tr><th><\/th><th style=\"text-align: left;width: 75px\">Peaks<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> \u00a0(30 m)<\/th><th style=\"text-align: center;width: 75px\">t<sub>R<\/sub> \u00a0(LPGC)<\/th><th style=\"text-align: center;width: 75px\">Conc. (\u00b5g\/mL)<\/th><\/tr><\/thead>\n<tbody><tr><td class=\"num\">1.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 3-MCPD\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/96-24-2\/3-MCPD\" target=\"_blank\" rel=\"noopener\">3-MCPD<\/a><\/td><td class=\"oth\">7.767<\/td><td class=\"oth\">2.921<\/td><td class=\"oth\">30<\/td><\/tr>\n<tr><td class=\"num\">2.<\/td><td class=\"cmpd\"><a class=\"cmpd_link\" title=\"View compound information for 2-MCPD\" href=\"https:\/\/ez.restek.com\/compound\/view\/en\/497-04-1\/2-MCPD\" target=\"_blank\" rel=\"noopener\">2-MCPD<\/a><\/td><td class=\"oth\">8.103<\/td><td class=\"oth\">3.075<\/td><td class=\"oth\">50<\/td><\/tr>\n<\/tbody><\/table><\/div><div class=\"chromatogram-conditions\"><h4>Conditions<\/h4><div class=\"conditions-container container-fluid\"><div class=\"row\"><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Column<\/th><td>See notes<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Standard\/Sample<\/th><td><\/td><\/tr><tr><td><\/td><td>3-MCPD<\/td><\/tr><tr><td><\/td><td>2-MCPD<\/td><\/tr>\n<tr><th class=\"sub conditions_header\" scope=\"row\">Diluent:<\/th><td>Isooctane<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Conc.:<\/th><td>30-50 ppm (See the peak table.)<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Injection<\/th><td><\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Vol.:<\/th><td>1 \u00b5L split (split ratio 10:1)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Liner:<\/th><td>Topaz 4.0 mm ID single taper inlet liner w\/ wool  (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/23303?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_FS0595\" rel=\"noopener\">cat.# 23303<\/a>)<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Inj. Temp.:<\/th><td>280 \u00b0C<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Carrier Gas<\/th><td>He<\/td><\/tr><\/table><table class=\"conditions col-lg-6 col-12\"><tr><th class=\"conditions_header\" scope=\"row\">Detector<\/th><td>MS<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Mode:<\/th><td>Scan<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Transfer Line Temp.:<\/th><td>280 \u00b0C<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Analyzer Type:<\/th><td>Quadrupole <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Source Temp.:<\/th><td>330 \u00b0C<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Quad Temp.:<\/th><td>180 \u00b0C<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Electron Energy:<\/th><td>70 eV<\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Tune Type:<\/th><td>PFTBA <\/td><\/tr><tr><th class=\"sub conditions_header\" scope=\"row\">Ionization Mode:<\/th><td>EI <\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Instrument<\/th><td>Agilent 7890B GC &amp; 5977A MSD<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Sample Preparation<\/th><td>Standards were derivatized with 20 \u00b5L phenylboronic acid (PBA), saturated solution in diethyl ether, dried, and then reconstituted in 1 mL isooctane in a 2 mL, short-cap, screw-thread vial (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/21143?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_FS0595\" rel=\"noopener\">cat.# 21143<\/a>) and capped with a short-cap, screw-vial closure (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/24495?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_FS0595\" rel=\"noopener\">cat.# 24495<\/a>). Final concentrations are given in the peak table.<\/td><\/tr><tr class=\"cgram_header_row\"><th class=\"conditions_header\" scope=\"row\">Notes<\/th><td><b>Conventional (30 m) Analysis: <\/b><br \/>Column: Rxi-17Sil MS, 30 m, 0.25 mm ID, 0.25 \u00b5m (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/14123?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_FS0595\" rel=\"noopener\">cat.# 14123<\/a>)<br \/>Temp. program: 100 \u00b0C (hold 0.5 min) to 180 \u00b0C at 12 \u00b0C\/min to 320 \u00b0C at 25 \u00b0C\/min (hold 4 min)<br \/>Flow: 1.4 mL\/min<br \/>Scan start time: 3 min<br \/>Scan range: 50-350 amu<br \/>Scan rate: 8.5 scans\/sec<br \/><br \/><b>LPGC-MS Analysis: <\/b><br \/>Column: LPGC Rxi-17Sil MS column kit, includes 10 m x 0.32 mm ID x 0.25 \u03bcm Rxi-17Sil MS analytical column and 5 m x 0.15 mm ID Rxi restrictor factory connected via SilTite connector (<a target=\"_blank\" href=\"https:\/\/www.restek.com\/p\/11805?utm_source=chromatograms&amp;utm_medium=link&amp;utm_campaign=GC_FS0595\" rel=\"noopener\">cat.# 11805<\/a>)<br \/>Temp. program: 100 \u00b0C (hold 0.5 min) to 320 \u00b0C at 30 \u00b0C\/min (hold 5 min)<br \/>Flow: 0.9 mL\/min<br \/>Scan start time: 1.5 min<br \/>Scan range: 50-350 amu<br \/>Scan rate: 8.5 scans\/sec<\/td><\/tr><\/table><\/div><\/div><\/div><div class=\"chromatogram-pdf-link\"><a href=\"https:\/\/ez.restek.com\/images\/cgram\/gc_fs0595.pdf\" target=\"_blank\" rel=\"noopener noreferrer\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"18\" height=\"18\" viewBox=\"0 0 18 18\"><g data-name=\"Group 2996\"><path data-name=\"Rectangle 1246\" d=\"M0 0h18v18H0z\" style=\"fill: none;\"><\/path><\/g><g data-name=\"Group 2997\"><path data-name=\"Path 729\" d=\"M13.412 11.4v2.017H5.345V11.4H4v2.017a1.349 1.349 0 0 0 1.345 1.345h8.068a1.349 1.349 0 0 0 1.345-1.345V11.4zm-.672-2.694-.948-.948-1.741 1.735V4H8.706v5.493L6.965 7.758l-.948.948 3.361 3.361z\" transform=\"translate(-.437 -.414)\" style=\"fill: rgb(13, 123, 196);\"><\/path><\/g><\/svg>Download PDF<\/a><\/div><\/div><\/div>\n<\/div><\/div><\/div>\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n        <div class=\"cpb\">\n            <h3 class=\"cpb-heading\">Products Mentioned<\/h3>\n            <hr class=\"cpb-heading-underline\" \/>\n            <div class=\"cpb-list\">\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/11805\">                                Catalog No. 11805                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">LPGC Rxi-17Sil MS Column Kit<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/11805\">\u67e5\u770b\u4ea7\u54c1<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/23303\">                                Catalog No. 23303                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Topaz, Single Taper Inlet Liner, 4.0 mm x 6.5 x 78.5, for Agilent GCs, w\/Quartz Wool, Premium Deactivation, 5-pk.<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/23303\">\u67e5\u770b\u4ea7\u54c1<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/23849\">                                Catalog No. 23849                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">GC Accelerator Oven Insert Kit, for Agilent 5890, 6890, 7890, and 8890 GCs<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/23849\">\u67e5\u770b\u4ea7\u54c1<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/21143\">                                Catalog No. 21143                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Short-Cap Vial with Grad Marking Spot, 9-425 Screw-Thread, 2 mL, 9 mm, 12 x 32 (vial only), Amber, 1000-pk.<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/21143\">\u67e5\u770b\u4ea7\u54c1<\/a>\n                                                    <\/div>\n                    <\/div>\n                                    <div class=\"cpb-item\">\n                        <div class=\"cpb-col cpb-col--left\">\n                            <a class=\"cpb-catalog\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/24495\">                                Catalog No. 24495                            <\/a>                        <\/div>\n                        <div class=\"cpb-col cpb-col--middle\">\n                            <div class=\"cpb-title\">Short Screw Caps, Polypropylene, Screw-Thread, PTFE\/Silicone\/PTFE Septa, Black, Preassembled, 2.0 mL, 9 mm, 100-pk.<\/div>\n                        <\/div>\n                        <div class=\"cpb-col cpb-col--right\">\n                                                            <a class=\"cpb-view-btn\" target=\"_blank\" rel=\"noopener noreferrer\" href=\"https:\/\/www.restek.com\/p\/24495\">\u67e5\u770b\u4ea7\u54c1<\/a>\n                                                    <\/div>\n                    <\/div>\n                            <\/div>\n        <\/div>\n        \n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>This fast analysis of MCPDs by low-pressure GC-MS is 2x faster than conventional GC-MS analysis and offers up to 69% helium savings.<\/p>\n","protected":false},"author":11,"featured_media":7267,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[462],"tags":[],"industries-application":[2167,2169],"post-badge":[],"resource-type":[2623],"product-library":[2385,2372,2384],"resource-technique":[2294,2300,2301],"ppma_author":[414],"class_list":["post-43728","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles-fr","industries-application-food-beverage","industries-application-food-safety","resource-type-featured-application","product-library-ferrules-fittings-connectors","product-library-gas-chromatography-products","product-library-gc-columns","resource-technique-gas-chromatography-gc","resource-technique-low-pressure-gc-lpgc","resource-technique-mass-spectrometry-ms"],"acf":[],"taxonomy_info":{"category":[{"value":462,"label":"Articles"}],"industries-application":[{"value":2167,"label":"Food 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