{"id":43791,"date":"2025-07-28T00:00:00","date_gmt":"2025-07-28T00:00:00","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/liner-volume-matters\/"},"modified":"2026-01-02T18:21:06","modified_gmt":"2026-01-02T18:21:06","slug":"liner-volume-matters","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/zh-hans\/articles\/gnot4538\/liner-volume-matters","title":{"rendered":"Liner Volume Matters"},"content":{"rendered":"\n<p><strong>Author(s):<\/strong> Chris English<br>Restek Corporation<\/p>\n\n\n\n<p><strong>Published By:<\/strong> LCGC<\/p>\n\n\n\n<p><strong>Issue:<\/strong> 2, Volume, 21<\/p>\n\n\n\n<p><strong>Year of Publication:<\/strong> 2025<\/p>\n\n\n\n<p><strong>Link:<\/strong> <a href=\"https:\/\/www.chromatographyonline.com\/view\/liner-volume-matters\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.chromatographyonline.com\/view\/liner-volume-matters<\/a><\/p>\n\n\n\n<p><strong>Abstract:<\/strong> There are many different injection port liner configurations, all of which come in a variety of internal volumes. It has been well established that injecting too much solvent into a liner in splitless mode results in a vapor cloud that exceeds the internal volume of the liner, which then leads to peak distortion, split peaks, and poor reproducibility. High-molecular-weight compounds condense on the cooler surfaces outside of the liner and are not completely transferred onto the column causing carryover (memory effects) and compound bias. This is known as discrimination where an inverse relationship occurs between the molecular weight and response of a compound. Recent studies have demonstrated that injecting too little into a liner in splitless mode can cause band broadening and increased activity. This article will examine these effects in split mode.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Explore how injection port liner volume impacts chromatographic performance in splitless mode, including effects like peak distortion, compound discrimination, and band broadening.<\/p>\n","protected":false},"author":21,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[7],"tags":[],"industries-application":[],"post-badge":[],"resource-type":[568],"product-library":[2372,2386],"resource-technique":[],"hf_cat_post":[649],"ppma_author":[441],"class_list":["post-43791","post","type-post","status-publish","format-standard","hentry","category-articles","resource-type-third-party-peer-reviewed-publications","product-library-gas-chromatography-products","product-library-inlet-supplies"],"acf":[],"taxonomy_info":{"category":[{"value":7,"label":"Articles"}],"resource-type":[{"value":568,"label":"Third-Party &amp; Peer Reviewed Publications"}],"product-library":[{"value":2372,"label":"Gas Chromatography Products"},{"value":2386,"label":"Inlet Supplies"}]},"featured_image_src_large":false,"author_info":{"display_name":"Chris English","author_link":"https:\/\/discover.restek.com\/zh-hans\/author\/chris-english\/"},"comment_info":0,"category_info":[{"term_id":7,"name":"Articles","slug":"articles","term_group":0,"term_taxonomy_id":7,"taxonomy":"category","description":"","parent":0,"count":467,"filter":"raw","cat_ID":7,"category_count":467,"category_description":"","cat_name":"Articles","category_nicename":"articles","category_parent":0}],"tag_info":false,"authors":[{"term_id":441,"user_id":21,"is_guest":0,"slug":"chris-english","display_name":"Chris English","avatar_url":{"url":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-english-chris.png","url2x":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-english-chris.png"},"0":null,"1":"","2":"","3":"","4":"","5":"","6":"","7":"","8":""}],"_links":{"self":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts\/43791","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=43791"}],"version-history":[{"count":3,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts\/43791\/revisions"}],"predecessor-version":[{"id":79164,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts\/43791\/revisions\/79164"}],"wp:attachment":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=43791"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=43791"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=43791"},{"taxonomy":"industries-application","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/industries-application?post=43791"},{"taxonomy":"post-badge","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/post-badge?post=43791"},{"taxonomy":"resource-type","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/resource-type?post=43791"},{"taxonomy":"product-library","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/product-library?post=43791"},{"taxonomy":"resource-technique","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/resource-technique?post=43791"},{"taxonomy":"hf_cat_post","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/hf_cat_post?post=43791"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/ppma_author?post=43791"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}