{"id":43791,"date":"2025-07-28T00:00:00","date_gmt":"2025-07-28T00:00:00","guid":{"rendered":"https:\/\/discover.restek.com\/uncategorized\/liner-volume-matters\/"},"modified":"2026-01-02T18:21:06","modified_gmt":"2026-01-02T18:21:06","slug":"liner-volume-matters","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/zh-hans\/articles-fr\/gnot4538\/liner-volume-matters","title":{"rendered":"Liner Volume Matters"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Author(s):<\/strong> Chris English<br>Restek Corporation<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Published By:<\/strong> LCGC<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Issue:<\/strong> 2, Volume, 21<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Year of Publication:<\/strong> 2025<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Link:<\/strong> <a href=\"https:\/\/www.chromatographyonline.com\/view\/liner-volume-matters\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.chromatographyonline.com\/view\/liner-volume-matters<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract:<\/strong> There are many different injection port liner configurations, all of which come in a variety of internal volumes. It has been well established that injecting too much solvent into a liner in splitless mode results in a vapor cloud that exceeds the internal volume of the liner, which then leads to peak distortion, split peaks, and poor reproducibility. High-molecular-weight compounds condense on the cooler surfaces outside of the liner and are not completely transferred onto the column causing carryover (memory effects) and compound bias. This is known as discrimination where an inverse relationship occurs between the molecular weight and response of a compound. Recent studies have demonstrated that injecting too little into a liner in splitless mode can cause band broadening and increased activity. This article will examine these effects in split mode.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Explore how injection port liner volume impacts chromatographic performance in splitless mode, including effects like peak distortion, compound discrimination, and band broadening.<\/p>\n","protected":false},"author":21,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[462],"tags":[],"industries-application":[],"post-badge":[],"resource-type":[568],"product-library":[2408,2422],"resource-technique":[],"ppma_author":[441],"class_list":["post-43791","post","type-post","status-publish","format-standard","hentry","category-articles-fr","resource-type-third-party-peer-reviewed-publications","product-library-gas-chromatography-products-zh","product-library-inlet-supplies-zh"],"acf":[],"taxonomy_info":{"category":[{"value":462,"label":"Articles"}],"resource-type":[{"value":568,"label":"Third-Party &amp; Peer Reviewed Publications"}],"product-library":[{"value":2408,"label":"\u6c14\u76f8\u8272\u8c31\u76f8\u5173\u4ea7\u54c1"},{"value":2422,"label":"\u8fdb\u6837\u53e3\u8017\u6750"}]},"featured_image_src_large":false,"author_info":{"display_name":"Chris English","author_link":"https:\/\/discover.restek.com\/zh-hans\/author\/chris-english\/"},"comment_info":0,"category_info":[{"term_id":462,"name":"Articles","slug":"articles-fr","term_group":0,"term_taxonomy_id":462,"taxonomy":"category","description":"","parent":0,"count":463,"filter":"raw","cat_ID":462,"category_count":463,"category_description":"","cat_name":"Articles","category_nicename":"articles-fr","category_parent":0}],"tag_info":false,"authors":[{"term_id":441,"user_id":21,"is_guest":0,"slug":"chris-english","display_name":"Chris English","avatar_url":{"url":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-english-chris.png","url2x":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-english-chris.png"},"author_category":"1","first_name":"Chris","last_name":"English","user_url":"https:\/\/www.linkedin.com\/in\/chris-english-28214912\/","job_title":"Sr. R&D Manager","description":"Since 2004, Chris has managed a team of chemists in Restek's innovations laboratory who perform new product testing, method development, and applications work. Before taking the reins of our lab, he spent seven years as an environmental chemist and was critical to the development of Restek\u2019s current line of volatile GC columns. Prior to joining Restek, he operated a variety of gas chromatographic detectors conducting method development and sample analysis. Chris holds a BS in environmental science from Saint Michael's College."}],"_links":{"self":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts\/43791","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=43791"}],"version-history":[{"count":3,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts\/43791\/revisions"}],"predecessor-version":[{"id":79164,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts\/43791\/revisions\/79164"}],"wp:attachment":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=43791"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=43791"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=43791"},{"taxonomy":"industries-application","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/industries-application?post=43791"},{"taxonomy":"post-badge","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/post-badge?post=43791"},{"taxonomy":"resource-type","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/resource-type?post=43791"},{"taxonomy":"product-library","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/product-library?post=43791"},{"taxonomy":"resource-technique","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/resource-technique?post=43791"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/ppma_author?post=43791"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}