{"id":60132,"date":"2025-04-04T21:08:15","date_gmt":"2025-04-04T21:08:15","guid":{"rendered":"https:\/\/discover.restek.com\/?p=60132"},"modified":"2026-02-05T17:36:50","modified_gmt":"2026-02-05T17:36:50","slug":"biphenyl-history","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/zh-hans\/articles\/gnar4421\/biphenyl-history","title":{"rendered":"20 Years of Restek Innovation: The Biphenyl Story"},"content":{"rendered":"\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">From Small Idea to Big Dream<\/h2>\n\n\n<style>.kb-image60132_e54778-7b.kb-image-is-ratio-size, .kb-image60132_e54778-7b .kb-image-is-ratio-size{max-width:206px;width:100%;}.wp-block-kadence-column > .kt-inside-inner-col > .kb-image60132_e54778-7b.kb-image-is-ratio-size, .wp-block-kadence-column > .kt-inside-inner-col > .kb-image60132_e54778-7b .kb-image-is-ratio-size{align-self:unset;}.kb-image60132_e54778-7b figure{max-width:206px;}.kb-image60132_e54778-7b .image-is-svg, .kb-image60132_e54778-7b .image-is-svg img{width:100%;}.kb-image60132_e54778-7b .kb-image-has-overlay:after{opacity:0.3;}<\/style>\n<div class=\"wp-block-kadence-image kb-image60132_e54778-7b\"><figure class=\"alignright size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"239\" src=\"https:\/\/discover.restek.com\/wp-content\/uploads\/Biphenyl-20-years-logo-final-300x239.png\" alt=\"\" class=\"kb-img wp-image-12304\" title=\"-\" srcset=\"https:\/\/discover.restek.com\/wp-content\/uploads\/Biphenyl-20-years-logo-final-300x239.png 300w, https:\/\/discover.restek.com\/wp-content\/uploads\/Biphenyl-20-years-logo-final-1024x816.png 1024w, https:\/\/discover.restek.com\/wp-content\/uploads\/Biphenyl-20-years-logo-final-768x612.png 768w, https:\/\/discover.restek.com\/wp-content\/uploads\/Biphenyl-20-years-logo-final.png 1194w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure><\/div>\n\n\n\n<p>In 2005, a team within our LC development group began working on a novel phenyl chemistry centered around the biphenyl molecule. The dream was to develop a new stationary phase, one with a unique selectivity compared to other LC columns. Achieving this would provide labs with a novel tool to help with their LC analysis\u2014an exciting prospect for any team. Little did they know how big an impact they were about to make on the entire chromatography industry.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>\u201cThe advantages found in using the Biphenyl column are certainly the high price-quality ratio, the durability of the column, in terms of numbers of injections, as well as the analytical reproducibility\u201d<\/em> &#8211; <strong>Cedam Italia, Italy<\/strong><\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">\u201cWe knew it was different, and different is good.\u201d<\/h2>\n\n\n\n<p>Early results on prototype columns instantly demonstrated our Biphenyl LC column&#8217;s truly unique selectivity. It proved to be especially useful for analytes containing electron-withdrawing functionalities and could also be easily modified from analysis to analysis with varying mobile phase conditions. Additionally, it was particularly adept at separating compounds that are hard to resolve on C18 columns. Randy Romesberg, one of the scientists who helped develop this phase, stated \u201cWe knew it was different, and different is good.\u201d<\/p>\n\n\n\n<p>The team had achieved a first in the industry\u2014the launch of the first LC column with a Biphenyl stationary phase.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>\u201cThe separation of aflatoxin B1, G1, B2, G2, OTA, zearalenone, deoxynivalenol, T2, H-T2, fumonisin B1 and B2 after CrossTOX cleanup in high-throughput mycotoxin analysis was very good. The shorter conditioning times were also very beneficial. I can certainly also imagine the Inert Biphenyl column as an alternative for other applications.\u201d<\/em><br>&#8211;\u00a0<strong>LCTech GMbH, Germany<\/strong><\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">The Right Phase at the Right Time<\/h2>\n\n\n\n<p>Long regarded as having superior chromatographic performance in drugs of abuse analysis, Restek&#8217;s Biphenyl LC column became an essential tool at the height of the U.S. opioid crisis in 2011. Our <a href=\"https:\/\/discover.restek.com\/cfss2310\/big-pain-assays-arent-a-big-pain-with-the-raptor-biphenyl-lc-column\/\">Big Pain Application<\/a> demonstrates its incredible performance when separating 231 compounds, 40+ isobars, 10 drug classes, and 22 ESI- compounds in 10 minutes. The Biphenyl\u2019s incredible separating power and superiority in pain management applications made it a clear choice for clinical testing laboratories across the U.S.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>\u201cWe were able to easily validate the iMethod on the Restek Raptor Biphenyl\u2026 for our 50 analyte pain panel on the AB Sciex Triple Quad 4500. We were able to achieve a faster run time than our previous column, with great separation between analytes, especially with opiates. We have been very happy with the column and currently run it for all four of our Triple Quad 4500s.\u201d<\/em><br>&#8211; <strong>Oklahoma Pain Center, U.S.<\/strong><\/p>\n<\/blockquote>\n\n\n\n<h2 class=\"wp-block-heading\">20 Years of Restek Innovation<\/h2>\n\n\n\n<p>From our founding 40 years ago to today, we haven\u2019t stopped innovating. For our biphenyl phase, that means pairing it with the most advanced column hardware in the industry. Now available across five column families, including our latest Raptor and Force Inert columns, Restek&#8217;s Biphenyl LC column has cemented itself as a key achievement for all Restek and a huge milestone for chromatography.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns has-background is-layout-flex wp-container-core-columns-is-layout-d735db0d wp-block-columns-is-layout-flex\" style=\"border-radius:10px;background-color:#f0f0f0;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:20px;padding-right:20px;padding-bottom:20px;padding-left:20px;flex-basis:75%\">\n<h3 class=\"wp-block-heading has-text-color has-link-color wp-elements-2080a3e998ceb4c9031f8358ea9d5c7f\" style=\"color:#02366d\">See Biphenyl in Action<\/h3>\n\n\n\n<p class=\"has-medium-font-size\"><a href=\"https:\/\/discover.restek.com\/gnss3457\/restek-biphenyl\/\" data-type=\"post\" data-id=\"43843\">Explore how this innovative phase can help you with your analysis. Learn More\u2192<\/a><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\" style=\"padding-top:10px;padding-right:15px;padding-bottom:10px;padding-left:15px;flex-basis:33.33%\"><div class=\"wp-block-image\">\n<figure class=\"alignright size-medium\" style=\"margin-top:20px;margin-right:20px;margin-bottom:20px;margin-left:20px\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"92\" src=\"https:\/\/discover.restek.com\/wp-content\/uploads\/teaser-biphenyl-column-GNAR4421-300x92.png\" alt=\"\" class=\"wp-image-29320\" style=\"object-fit:cover\" title=\"-\" srcset=\"https:\/\/discover.restek.com\/wp-content\/uploads\/teaser-biphenyl-column-GNAR4421-300x92.png 300w, https:\/\/discover.restek.com\/wp-content\/uploads\/teaser-biphenyl-column-GNAR4421.png 400w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><style>.wp-block-kadence-advancedbtn.kb-btns60132_c60d4e-a2{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns60132_c60d4e-a2 .kt-button{font-weight:normal;font-style:normal;}.kt-btns60132_c60d4e-a2 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns60132_c60d4e-a2 .kt-btn-wrap-0 .kt-button{color:#555555;border-color:#555555;}.wp-block-kadence-advancedbtn.kt-btns60132_c60d4e-a2 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns60132_c60d4e-a2 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns60132_c60d4e-a2 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns60132_c60d4e-a2 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns60132_c60d4e-a2 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kb-buttons-wrap kb-btns60132_c60d4e-a2\"><style>ul.menu .wp-block-kadence-advancedbtn .kb-btn60132_dd1455-45.kb-button{width:initial;}.wp-block-kadence-advancedbtn .kb-btn60132_dd1455-45.kb-button{background:#00265d;}<\/style><a class=\"kb-button kt-button button kb-btn60132_dd1455-45 kt-btn-size-standard kt-btn-width-type-full kb-btn-global-fill  kt-btn-has-text-true kt-btn-has-svg-false  wp-block-kadence-singlebtn\" href=\"https:\/\/www.restek.com\/c\/1458\" target=\"_blank\" rel=\"noopener\"><span class=\"kt-btn-inner-text\">Biphenyl Products<\/span><\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><style>.wp-block-kadence-advancedbtn.kb-btns60132_398f3c-14{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns60132_398f3c-14 .kt-button{font-weight:normal;font-style:normal;}.kt-btns60132_398f3c-14 .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns60132_398f3c-14 .kt-btn-wrap-0 .kt-button{color:#555555;border-color:#555555;}.wp-block-kadence-advancedbtn.kt-btns60132_398f3c-14 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns60132_398f3c-14 .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns60132_398f3c-14 .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns60132_398f3c-14 .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns60132_398f3c-14 .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kb-buttons-wrap kb-btns60132_398f3c-14\"><style>ul.menu .wp-block-kadence-advancedbtn .kb-btn60132_d31f77-0f.kb-button{width:initial;}.wp-block-kadence-advancedbtn .kb-btn60132_d31f77-0f.kb-button{background:#00265d;}<\/style><a class=\"kb-button kt-button button kb-btn60132_d31f77-0f kt-btn-size-standard kt-btn-width-type-full kb-btn-global-fill  kt-btn-has-text-true kt-btn-has-svg-false  wp-block-kadence-singlebtn\" href=\"https:\/\/explore.restek.com\/biphenyl-contact\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"kt-btn-inner-text\">Contact Us<\/span><\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>20 Years of Restek Innovation: The Biphenyl 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