{"id":84067,"date":"2026-01-22T20:48:33","date_gmt":"2026-01-22T20:48:33","guid":{"rendered":"https:\/\/discover.restek.com\/?p=84067"},"modified":"2026-01-22T20:48:37","modified_gmt":"2026-01-22T20:48:37","slug":"consolidating-lc-ms-ms-method-conditions-for-the-analysis-of-alcohol-metabolites-barbiturates-and-drugs-of-abuse-3","status":"publish","type":"post","link":"https:\/\/discover.restek.com\/zh-hans\/posters-presentations-fr\/gnot5371\/consolidating-lc-ms-ms-method-conditions-for-the-analysis-of-alcohol-metabolites-barbiturates-and-drugs-of-abuse-3","title":{"rendered":"Consolidating LC-MS\/MS Method Conditions for the Analysis of Alcohol Metabolites, Barbiturates, and Drugs of Abuse"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Efficiency is key in toxicology laboratories where multiple drug panels must be run daily. Consolidating multiple drug panels into large, multi-class drug assays can streamline the analytical testing process and reduce operating costs. To simplify the analysis of alcohol metabolites, barbiturates, THC metabolites, and drugs of abuse, three different LC-MS\/MS methods were developed for each analyte class using the same analytical column and mobile phases.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A panel of 100 drugs of abuse, novel psychoactive substances, therapeutic drugs and metabolites, a panel of biomarkers of alcohol consumption, and a panel of barbiturates and cannabinoid metabolites were all analyzed using the same analytical column and mobile phase set up.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This work highlights the ability of one LC-MS\/MS setup to analyze multiple toxicology panels. This allows for laboratories to simplify testing procedures, save time, and reduce operating costs.<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/discover.restek.com\/wp-content\/uploads\/poster-soft-2024-Consolidating-LC-MSMS-Method-Conditions-for-the-Analysis-of-Alcohol-Metabolites-Barbiturates-and-Drugs-of-Abuse.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of poster-soft-2024-Consolidating LC-MSMS Method Conditions for the Analysis of Alcohol Metabolites, Barbiturates, and Drugs of Abuse.\"><\/object><a id=\"wp-block-file--media-bbd66920-7b9e-441b-94ea-897e4e670a60\" href=\"https:\/\/discover.restek.com\/wp-content\/uploads\/poster-soft-2024-Consolidating-LC-MSMS-Method-Conditions-for-the-Analysis-of-Alcohol-Metabolites-Barbiturates-and-Drugs-of-Abuse.pdf\">poster-soft-2024-Consolidating LC-MSMS Method Conditions for the Analysis of Alcohol Metabolites, Barbiturates, and Drugs of Abuse<\/a><a href=\"https:\/\/discover.restek.com\/wp-content\/uploads\/poster-soft-2024-Consolidating-LC-MSMS-Method-Conditions-for-the-Analysis-of-Alcohol-Metabolites-Barbiturates-and-Drugs-of-Abuse.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-bbd66920-7b9e-441b-94ea-897e4e670a60\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Efficiency is key in toxicology laboratories where multiple drug panels must be run daily. Consolidating multiple drug panels into large, multi-class drug assays can streamline the analytical testing process and reduce operating costs. To simplify the analysis of alcohol metabolites, barbiturates, THC metabolites, and drugs of abuse, three different LC-MS\/MS methods were developed for each&#8230;<\/p>\n","protected":false},"author":53,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[812],"tags":[],"industries-application":[],"post-badge":[],"resource-type":[],"product-library":[],"resource-technique":[],"ppma_author":[608,579,432,702],"class_list":["post-84067","post","type-post","status-publish","format-standard","hentry","category-posters-presentations-fr"],"acf":[],"taxonomy_info":{"category":[{"value":812,"label":"Posters &amp; Presentations"}]},"featured_image_src_large":false,"author_info":{"display_name":"Paul Connolly","author_link":"https:\/\/discover.restek.com\/zh-hans\/author\/paul-connolly\/"},"comment_info":0,"category_info":[{"term_id":812,"name":"Posters &amp; Presentations","slug":"posters-presentations-fr","term_group":0,"term_taxonomy_id":812,"taxonomy":"category","description":"","parent":0,"count":118,"filter":"raw","cat_ID":812,"category_count":118,"category_description":"","cat_name":"Posters &amp; Presentations","category_nicename":"posters-presentations-fr","category_parent":0}],"tag_info":false,"authors":[{"term_id":608,"user_id":53,"is_guest":0,"slug":"paul-connolly","display_name":"Paul Connolly","avatar_url":{"url":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-connolly-paul.png","url2x":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-connolly-paul.png"},"author_category":"1","first_name":"Paul","last_name":"Connolly","user_url":"","job_title":"","description":""},{"term_id":579,"user_id":47,"is_guest":0,"slug":"jamie-l-york-phd","display_name":"Jamie L. York, PhD","avatar_url":{"url":"https:\/\/discover.restek.com\/wp-content\/uploads\/york-jamie-1000x1000-1-e1765483005988.jpg","url2x":"https:\/\/discover.restek.com\/wp-content\/uploads\/york-jamie-1000x1000-1-e1765483005988.jpg"},"author_category":"1","first_name":"Jamie","last_name":"York","user_url":"","job_title":"","description":"Jamie York is a principal scientist in the Applications Lab at Restek Corporation. She leads the development of innovative analytical methods tailored to the food, clinical, environmental, and cannabis markets. Jamie earned her PhD in chemistry from The University of Texas at Arlington, where she gained extensive expertise in a range of analytical techniques, including gas chromatography\u2013vacuum ultraviolet (GC\u2013VUV); gas chromatography\u2013mass spectrometry (GC\u2013MS); matrix-assisted laser desorption\/ionization (MALDI); and liquid chromatography\u2013 mass spectrometry (LC\u2013MS\/MS); with a research emphasis on food and environmental analysis. Today, her work focuses on complex method development and advanced sample preparation strategies to support the evolving needs of the scientific community."},{"term_id":432,"user_id":13,"is_guest":0,"slug":"haley-berkland-ms","display_name":"Haley Berkland, MS","avatar_url":{"url":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-berkland-haley.jpg","url2x":"https:\/\/discover.restek.com\/wp-content\/uploads\/people-berkland-haley.jpg"},"author_category":"1","first_name":"Haley","last_name":"Berkland","user_url":"","job_title":"Advanced Scientist, LC Solutions","description":"Haley is an LC applications scientist at Restek. She attended Duquesne University, receiving her bachelor's degree in biochemistry and a master's degree in forensic science and law. As a graduate student, she performed research on the detection of drugs of abuse in vitreous humor by LC-MS\/MS. Before joining Restek in 2023, Haley spent four years working as a forensic toxicologist. While in this role, she performed analysis of postmortem toxicology casework, identification of seized drug evidence, and development\/validation of new assays by LC-MS\/MS, GC-MS, and GC-FID."},{"term_id":702,"user_id":0,"is_guest":1,"slug":"justin-steimling","display_name":"Justin Steimling","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/?s=96&d=mm&r=g","author_category":"1","first_name":"Justin","last_name":"Steimling","user_url":"","job_title":"","description":""}],"_links":{"self":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts\/84067","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/users\/53"}],"replies":[{"embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=84067"}],"version-history":[{"count":1,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts\/84067\/revisions"}],"predecessor-version":[{"id":84069,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/posts\/84067\/revisions\/84069"}],"wp:attachment":[{"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=84067"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=84067"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=84067"},{"taxonomy":"industries-application","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/industries-application?post=84067"},{"taxonomy":"post-badge","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/post-badge?post=84067"},{"taxonomy":"resource-type","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/resource-type?post=84067"},{"taxonomy":"product-library","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/product-library?post=84067"},{"taxonomy":"resource-technique","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/resource-technique?post=84067"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/discover.restek.com\/zh-hans\/wp-json\/wp\/v2\/ppma_author?post=84067"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}