The significant difference is the ruggedness of the bonded phase. With the ARC-18, any residual silanol groups are shielded and made inert through steric protection. The result is a wider operating pH range of 1.0–8.0. The ARC-18 is particularly useful between a pH of 1.0 and 3.0 where other C18 column phases may begin to degrade under these harsh conditions. Like the Raptor Biphenyl column, the stationary phase is bonded to superficially porous silica particles (SPP).
How do Raptor ARC-18 columns differ from ordinary C18s?
31 Jul 2025
Author
GNOT5066
