Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) are established biomarkers for alcohol consumption. The analysis of these compounds poses challenges due to their polar nature, making them challenging to retain by reversed phase chromatography. In addition to this, there are isobaric matrix interferences in urine that require full resolution from the analytes to obtain accurate data. In this work, a rapid LC method was developed to demonstrate excellent resolution between the matrix interferences and analytes of interest without the need for column conditioning.
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